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anti-SLC35D2 antibody :: Rabbit anti-Human SLC35D2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151008
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC35D2, Polyclonal Antibody

★Popular Item★
 Also Known As   

SLC35D2 Antibody

 Product Synonym Names    SLC35D2; hfrc; HFRC1; SQV7L; UGTrel8; HFRC; UGTREL8; Homolog of Fringe connection protein 1; solute carrier family 35, member D2
 Product Gene Name   

anti-SLC35D2 antibody

[Similar Products]
 Antibody/Peptide Pairs    SLC35D2 peptide (MBS152870) is used for blocking the activity of SLC35D2 antibody (MBS151008)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609182
 3D Structure    ModBase 3D Structure for Q76EJ3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    At least two isoforms of SLC35D2 are known to exist; this antibody will recognize both isoforms. SLC35D2 antibody is predicted to not cross-react with SLC35D1 or SLC35D3.
 Purity/Purification    SLC35D2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    SLC35D2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human SLC35D2.
 Buffer    SLC35D2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    SLC35D2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-SLC35D2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SLC35D2 antibody

   SLC35D2 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident SLC family member SLC35D2 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. Its overexpression in transfected cells modulated cell surface heparin sulfate expression, suggesting that SLC35D2 is involved in heparin sulfate synthesis. SLC35D2-overexpressing cells also showed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc, suggesting that SLC35D2 may be involved in UDP-sugar release and cell signaling.
 Applications Tested/Suitable for anti-SLC35D2 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-SLC35D2 antibody    SLC35D2 antibody can be used for detection of SLC35D2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.
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 Western Blot (WB) of anti-SLC35D2 antibody    Western blot analysis of SLC35D2 in HeLa cell lysate with SLC35D2 antibody at (A) 1 and (B) 2 μg/mL.
anti-SLC35D2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-SLC35D2 antibody    Immunocytochemistry of SLC35D2 in HeLa cells with SLC35D2 antibody at 5 μg/mL.
anti-SLC35D2 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for SLC35D2. It may not necessarily be applicable to this product.
 NCBI GI #    223029426
 NCBI GeneID    11046
 NCBI Accession #    NP_008932 [Other Products]
 NCBI GenBank Nucleotide #    NM_007001.2 [Other Products]
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 UniProt Primary Accession #    Q76EJ3 [Other Products]
 UniProt Secondary Accession #    O95454; Q498C1; Q75W21; Q7Z5X5 [Other Products]
 UniProt Related Accession #    Q76EJ3 [Other Products]
 Molecular Weight    26,702 Da
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 NCBI Official Full Name    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a
 NCBI Official Synonym Full Names    solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
 NCBI Official Symbol    SLC35D2 [Similar Products]
 NCBI Official Synonym Symbols   
hfrc; HFRC1; SQV7L; UGTrel8
[Similar Products]
 NCBI Protein Information    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; SQV7-like protein; fringe connection; UDP-N-acetylglucosamine transporter; solute carrier family 35, member D2; homolog of Fringe connection protein 1; UDP-galactose transporter-related protein 8
 UniProt Protein Name    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
 UniProt Synonym Protein Names   
Homolog of Fringe connection protein 1; HFRC1; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8
 Protein Family    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
 UniProt Gene Name    SLC35D2 [Similar Products]
 UniProt Synonym Gene Names    HFRC; UGTREL8; HFRC1; SQV7L; UGTrel8 [Similar Products]
 UniProt Entry Name    S35D2_HUMAN
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 NCBI Summary for SLC35D2    Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for SLC35D2    SLC35D2: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q22.32

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: nucleotide-sugar transmembrane transporter activity

Biological Process: keratan sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate transport; carbohydrate metabolic process; keratan sulfate biosynthetic process; pathogenesis; transmembrane transport
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 Research Articles on SLC35D2    1. HFRC1 was overexpressed in human bronchial epithelial cells and was shown to localize in the Golgi and to enhance the surface expression of N-acetylglucosamine-rich glycans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC35D2 antibodyPathways associated with anti-SLC35D2 antibody
 Reference Product  PubMed Publications
 SLC35F4 antibody  >1 publications with SLC35D2 and SLC35F4
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with anti-SLC35D2 antibodyOrgans/Tissues associated with anti-SLC35D2 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >1 publications with SLC35D2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with SLC35D2 and Lung
 Ovary Antibodies  >1 publications with SLC35D2 and Ovary
 Thyroid Antibodies  >1 publications with SLC35D2 and Thyroid
 Testis Antibodies  >1 publications with SLC35D2 and Testis
 Prostate Antibodies  >1 publications with SLC35D2 and Prostate
 Kidney Antibodies  >1 publications with SLC35D2 and Kidney
 Spleen Antibodies  >1 publications with SLC35D2 and Spleen
 Mammary Gland Antibodies  >1 publications with SLC35D2 and Mammary Gland
 Adipose Tissue Antibodies  >1 publications with SLC35D2 and Adipose Tissue
 Bone Antibodies  >1 publications with SLC35D2 and Bone
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