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anti-SLC6A4 antibody :: Rabbit anti-Human, Mouse SLC6A4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628823 anti-SLC6A4 antibody
Unit / Price
0.1 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC6A4, Polyclonal Antibody

★Popular Item★
 Also Known As   

SLC6A4 (Solute Carrier Family 6 Member 4, Sodium-dependent Serotonin Transporter, 5HT Transporter, 5HTT, HTT, SERT)

 Product Synonym Names    Anti -SLC6A4 (Solute Carrier Family 6 Member 4, Sodium-dependent Serotonin Transporter, 5HT Transporter, 5HTT, HTT, SERT)
 Product Gene Name   

anti-SLC6A4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (28521337..28562986, complement). Location: 17q11.2
 OMIM    103780
 3D Structure    ModBase 3D Structure for P31645
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes human SLC6A4. Species Crossreactivity: mouse
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    SLC6A4 (AAH69484.1, 1-630aa) full-length human protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-SLC6A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SLC6A4 antibody

   This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
 Product Categories/Family for anti-SLC6A4 antibody    Antibodies; Abs to Transport Proteins
 Applications Tested/Suitable for anti-SLC6A4 antibody   

Western Blot (WB)

 Application Notes for anti-SLC6A4 antibody    Suitable for use in Western Blot.
Dilution: Western Blot (Tissue lysate): 1:500-1:1000. A specific band of ~75kD was detected using mouse lung lysate.
Western Blot (Transfected lysate): 1:1000-1:2000. A specific band of ~70.3kD was detected using SLC6A4 transfectged 293T lysate.
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NCBI/Uniprot data below describe general gene information for SLC6A4. It may not necessarily be applicable to this product.
 NCBI GI #    4507043
 NCBI GeneID    6532
 NCBI Accession #    NP_001036.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001045.5 [Other Products]
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 UniProt Primary Accession #    P31645 [Other Products]
 UniProt Secondary Accession #    Q5EE02 [Other Products]
 UniProt Related Accession #    P31645; AAB26687 [Other Products]
 Molecular Weight    70,325 Da [Similar Products]
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 NCBI Official Full Name    sodium-dependent serotonin transporter
 NCBI Official Synonym Full Names    solute carrier family 6 (neurotransmitter transporter), member 4
 NCBI Official Symbol    SLC6A4 [Similar Products]
 NCBI Official Synonym Symbols   
HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR
[Similar Products]
 NCBI Protein Information    sodium-dependent serotonin transporter; 5HT transporter; serotonin transporter 1; 5-hydroxytryptamine transporter; Na+/Cl- dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
 UniProt Protein Name    Sodium-dependent serotonin transporter
 UniProt Synonym Protein Names   
5HT transporter; 5HTT; Solute carrier family 6 member 4
 UniProt Gene Name    SLC6A4 [Similar Products]
 UniProt Synonym Gene Names    HTT; SERT; 5HTT [Similar Products]
 UniProt Entry Name    SC6A4_HUMAN
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 NCBI Summary for SLC6A4    This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SLC6A4    SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; endomembrane system; endosome membrane; cytosol; lipid raft

Molecular Function: actin filament binding; serotonin transmembrane transporter activity; protein binding; protein homodimerization activity; myosin binding; serotonin:sodium symporter activity; cocaine binding; monoamine transmembrane transporter activity; syntaxin-1 binding; nitric-oxide synthase binding; Rab GTPase binding

Biological Process: response to drug; circadian rhythm; vasoconstriction; response to toxin; monoamine transport; positive regulation of cell cycle; thalamus development; social behavior; serotonin uptake; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; response to estradiol stimulus; memory; protein oligomerization; negative regulation of granule cell precursor proliferation; negative regulation of neuron differentiation; response to hypoxia; brain morphogenesis; sperm ejaculation; serotonin transport; transmembrane transport; protein homooligomerization; response to nutrient

Disease: Anxiety; Obsessive-compulsive Disorder
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 Research Articles on SLC6A4    1. found no interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC6A4 antibodyPathways associated with anti-SLC6A4 antibody
 Reference Product  PubMed Publications
 DRD4 antibody  >95 publications with SLC6A4 and DRD4
 HTR1A antibody  >39 publications with SLC6A4 and HTR1A
 PPP2CA antibody  >4 publications with SLC6A4 and PPP2CA
 ERP44 antibody  >1 publications with SLC6A4 and ERP44
 MARCKSL1 antibody  >1 publications with SLC6A4 and MARCKSL1
 SEC24D antibody  >1 publications with SLC6A4 and SEC24D
 PRKG1 antibody  >1 publications with SLC6A4 and PRKG1
 AKT1 antibody  >1 publications with SLC6A4 and AKT1
 Products by Pathway  Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
Diseases associated with anti-SLC6A4 antibodyOrgans/Tissues associated with anti-SLC6A4 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >1287 publications with SLC6A4 and Mental Disorders
 Mood Disorders Antibodies  >593 publications with SLC6A4 and Mood Disorders
 Depressive Disorder Antibodies  >439 publications with SLC6A4 and Depressive Disorder
 Anxiety Disorders Antibodies  >322 publications with SLC6A4 and Anxiety Disorders
 Nervous System Diseases Antibodies  >289 publications with SLC6A4 and Nervous System Diseases
 Depressive Disorder, Major Antibodies  >288 publications with SLC6A4 and Depressive Disorder, Major
 Substance-Related Disorders Antibodies  >218 publications with SLC6A4 and Substance-Related Disorders
 Brain Diseases Antibodies  >208 publications with SLC6A4 and Brain Diseases
 Bipolar Disorder Antibodies  >140 publications with SLC6A4 and Bipolar Disorder
 Personality Disorders Antibodies  >138 publications with SLC6A4 and Personality Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1300 publications with SLC6A4 and Brain
 Intestine Antibodies  >37 publications with SLC6A4 and Intestine
 Lung Antibodies  >35 publications with SLC6A4 and Lung
 Liver Antibodies  >32 publications with SLC6A4 and Liver
 Placenta Antibodies  >29 publications with SLC6A4 and Placenta
 Bone Antibodies  >16 publications with SLC6A4 and Bone
 Mouth Antibodies  >12 publications with SLC6A4 and Mouth
 Connective Tissue Antibodies  >7 publications with SLC6A4 and Connective Tissue
 Pancreas Antibodies  >4 publications with SLC6A4 and Pancreas
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