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anti-SMAD2 antibody :: Rabbit SMAD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8205104
Unit / Price
0.03 mL  /  $165 +1 FREE 8GB USB
0.1 mL  /  $245 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMAD2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-SMAD2 (pS465) Antibody

 Product Synonym Names    MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
 Product Gene Name   

anti-SMAD2 antibody

[Similar Products]
 Antibody/Peptide Pairs    SMAD2 peptide (MBS8237172) is used for blocking the activity of SMAD2 antibody (MBS8205104)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601366
 3D Structure    ModBase 3D Structure for Q15796
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rabbit, Bovine, Chicken, Monkey, Porcine, Rabbit, Sheep, Zebrafish
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 Specificity    Recognizes endogenous levels of SMAD2 (pS465) protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SMAD2 (pS465). The exact sequence is proprietary.
 Source    Rabbit
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-SMAD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SMAD2 antibody

   Rabbit polyclonal antibody to SMAD2 (pS465)
 Applications Tested/Suitable for anti-SMAD2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SMAD2 antibody    WB (1/500 - 1/1000)
IHC (1/100 - 1/200)
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 Western Blot (WB) of anti-SMAD2 antibody    Western blot analysis of SMAD2 (pS465) expression in HepG2 (A) whole cell lysates.
anti-SMAD2 antibody Western Blot (WB) (WB) image
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 Immunohistochemical of anti-SMAD2 antibody    Immunohistochemical analysis of SMAD2 (pS465) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-SMAD2 antibody Immunohistochemical image
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NCBI/Uniprot data below describe general gene information for SMAD2. It may not necessarily be applicable to this product.
 NCBI GI #    51173730
 NCBI GeneID    4087
 NCBI Accession #    NP_001003652.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003652.3 [Other Products]
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 UniProt Primary Accession #    Q15796 [Other Products]
 UniProt Related Accession #    Q15796 [Other Products]
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 NCBI Official Full Name    mothers against decapentaplegic homolog 2 isoform 1
 NCBI Official Synonym Full Names    SMAD family member 2
 NCBI Official Symbol    SMAD2 [Similar Products]
 NCBI Official Synonym Symbols   
JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 2
 UniProt Protein Name    Mothers against decapentaplegic homolog 2
 UniProt Synonym Protein Names   
JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD2 [Similar Products]
 UniProt Synonym Gene Names    MADH2; MADR2; MAD homolog 2; Mothers against DPP homolog 2; hMAD-2; SMAD 2; Smad2; hSMAD2 [Similar Products]
 UniProt Entry Name    SMAD2_HUMAN
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 NCBI Summary for SMAD2    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for SMAD2    SMAD2: ubiquitously expressed transcription factor phosphorylated and activated by TGF-beta receptor-type kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; cytoplasm; cytosol; nucleus

Molecular Function: transcription activator binding; metal ion binding; transcription factor binding; phosphatase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; protein binding; DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; chromatin binding; SMAD binding; transforming growth factor beta receptor binding; transcription factor activity

Biological Process: developmental growth; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; paraxial mesoderm morphogenesis; gastrulation; negative regulation of transcription from RNA polymerase II promoter; palate development; primary microRNA processing; post-embryonic development; anterior/posterior pattern formation; negative regulation of cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; ureteric bud development; transforming growth factor beta receptor signaling pathway; embryonic foregut morphogenesis; pancreas development; response to glucose stimulus; positive regulation of BMP signaling pathway; pericardium development; transcription initiation from RNA polymerase II promoter; cell fate commitment; regulation of binding; transcription, DNA-dependent; in utero embryonic development; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; SMAD protein complex assembly; organ growth; zygotic determination of dorsal/ventral axis; mesoderm formation; insulin secretion; endoderm formation; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; lung development
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 Research Articles on SMAD2    1. A role for decorin and p-Smad-2 in the pathophysiology of fetal membranes and adverse pregnancy outcomes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SMAD2 antibodyPathways associated with anti-SMAD2 antibody
 Reference Product  PubMed Publications
 SMAD4 antibody  >915 publications with SMAD2 and SMAD4
 FOXH1 antibody  >59 publications with SMAD2 and FOXH1
 ACVR1B antibody  >40 publications with SMAD2 and ACVR1B
 SKIL antibody  >39 publications with SMAD2 and SKIL
 TGFBR1 antibody  >39 publications with SMAD2 and TGFBR1
 EP300 antibody  >14 publications with SMAD2 and EP300
 UBC antibody  >9 publications with SMAD2 and UBC
 CREBBP antibody  >7 publications with SMAD2 and CREBBP
 ZFYVE9 antibody  >3 publications with SMAD2 and ZFYVE9
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-SMAD2 antibodyOrgans/Tissues associated with anti-SMAD2 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >940 publications with SMAD2 and Fibrosis
 Carcinoma Antibodies  >391 publications with SMAD2 and Carcinoma
 Disease Models, Animal Antibodies  >387 publications with SMAD2 and Disease Models, Animal
 Inflammation Antibodies  >309 publications with SMAD2 and Inflammation
 Kidney Diseases Antibodies  >235 publications with SMAD2 and Kidney Diseases
 Liver Diseases Antibodies  >211 publications with SMAD2 and Liver Diseases
 Heart Diseases Antibodies  >168 publications with SMAD2 and Heart Diseases
 Breast Neoplasms Antibodies  >133 publications with SMAD2 and Breast Neoplasms
 Hypertrophy Antibodies  >120 publications with SMAD2 and Hypertrophy
 Liver Cirrhosis Antibodies  >111 publications with SMAD2 and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >738 publications with SMAD2 and Muscle
 Bone Antibodies  >511 publications with SMAD2 and Bone
 Blood Antibodies  >436 publications with SMAD2 and Blood
 Kidney Antibodies  >432 publications with SMAD2 and Kidney
 Lung Antibodies  >430 publications with SMAD2 and Lung
 Vascular Antibodies  >422 publications with SMAD2 and Vascular
 Liver Antibodies  >332 publications with SMAD2 and Liver
 Connective Tissue Antibodies  >296 publications with SMAD2 and Connective Tissue
 Heart Antibodies  >292 publications with SMAD2 and Heart
 Embryonic Tissue Antibodies  >252 publications with SMAD2 and Embryonic Tissue
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