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anti-SMAD4 antibody :: Rabbit SMAD4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2542362
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMAD4, Polyclonal Antibody

★Popular Item★
 Also Known As   

SMAD4 Polyclonal Antibody

 Product Synonym Names    JIP; DPC4; MADH4; MYHRS
 Product Gene Name   

anti-SMAD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF045447
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purification
 Concentration    1.8mg/ml (lot specific)
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 Immunogen    Fusion protein of human SMAD4
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1909 / sc-1908 / sc-7154
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 Preparation and Storage    Store at -20 degree C. Avoid freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SMAD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SMAD4 antibody

   This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
 Product Categories/Family for anti-SMAD4 antibody    Cancer
 Applications Tested/Suitable for anti-SMAD4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SMAD4 antibody    ELISA: 1:1000-2000
IHC: 1:50-200
WB: 1:200-500
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 Immunohistochemistry (IHC) of anti-SMAD4 antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer using SMAD4 Polyclonal Antibody at dilution of 1/40
anti-SMAD4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SMAD4 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer using SMAD4 Polyclonal Antibody at dilution of 1/40
anti-SMAD4 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SMAD4 antibody    Western Blot analysis of Human liver cancer tissue and Hela cells using SMAD4 Polyclonal Antibody at dilution of 1:150
anti-SMAD4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SMAD4. It may not necessarily be applicable to this product.
 NCBI GI #    13603414
 NCBI GeneID    4089
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 UniProt Secondary Accession #    A8K405 [Other Products]
 UniProt Related Accession #    Q13485 [Other Products]
 Molecular Weight    60 kDa
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 NCBI Official Full Name    SMAD4, partial
 NCBI Official Synonym Full Names    SMAD family member 4
 NCBI Official Symbol    SMAD4 [Similar Products]
 NCBI Official Synonym Symbols   
JIP; DPC4; MADH4; MYHRS
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 4
 UniProt Protein Name    Mothers against decapentaplegic homolog 4
 UniProt Synonym Protein Names   
Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD4 [Similar Products]
 UniProt Synonym Gene Names    DPC4; MADH4; MAD homolog 4; Mothers against DPP homolog 4; SMAD 4; Smad4; hSMAD4 [Similar Products]
 UniProt Entry Name    SMAD4_HUMAN
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 NCBI Summary for SMAD4    This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
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 UniProt Comments for SMAD4    SMAD4: transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; identical protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

Biological Process: BMP signaling pathway; cellular iron ion homeostasis; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; palate development; positive regulation of BMP signaling pathway; positive regulation of histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; SMAD protein complex assembly; somatic stem cell maintenance; transforming growth factor beta receptor signaling pathway

Disease: Juvenile Polyposis Syndrome; Juvenile Polyposis/hereditary Hemorrhagic Telangiectasia Syndrome; Myhre Syndrome; Pancreatic Cancer
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 Research Articles on SMAD4    1. we discovered a novel mechanism mediated by Smad4 to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SMAD4 antibodyPathways associated with anti-SMAD4 antibody
 Reference Product  PubMed Publications
 SMAD2 antibody  >990 publications with SMAD4 and SMAD2
 SMAD3 antibody  >885 publications with SMAD4 and SMAD3
 SMAD1 antibody  >314 publications with SMAD4 and SMAD1
 BMP2 antibody  >104 publications with SMAD4 and BMP2
 SKI antibody  >53 publications with SMAD4 and SKI
 TRIM33 antibody  >31 publications with SMAD4 and TRIM33
 SKIL antibody  >25 publications with SMAD4 and SKIL
 EP300 antibody  >13 publications with SMAD4 and EP300
 UBC antibody  >8 publications with SMAD4 and UBC
 PIAS4 antibody  >2 publications with SMAD4 and PIAS4
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 BMP Signalling Pathway antibodies  BMP Signalling Pathway Diagram
Diseases associated with anti-SMAD4 antibodyOrgans/Tissues associated with anti-SMAD4 antibody
 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >349 publications with SMAD4 and Colorectal Neoplasms
 Fibrosis Antibodies  >233 publications with SMAD4 and Fibrosis
 Liver Diseases Antibodies  >173 publications with SMAD4 and Liver Diseases
 Liver Neoplasms Antibodies  >151 publications with SMAD4 and Liver Neoplasms
 Disease Models, Animal Antibodies  >136 publications with SMAD4 and Disease Models, Animal
 Inflammation Antibodies  >113 publications with SMAD4 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >102 publications with SMAD4 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >101 publications with SMAD4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >91 publications with SMAD4 and Lung Neoplasms
 Juvenile polyposis syndrome Antibodies  >79 publications with SMAD4 and Juvenile polyposis syndrome
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >572 publications with SMAD4 and Bone
 Liver Antibodies  >308 publications with SMAD4 and Liver
 Blood Antibodies  >229 publications with SMAD4 and Blood
 Lung Antibodies  >216 publications with SMAD4 and Lung
 Muscle Antibodies  >205 publications with SMAD4 and Muscle
 Vascular Antibodies  >199 publications with SMAD4 and Vascular
 Pancreas Antibodies  >199 publications with SMAD4 and Pancreas
 Embryonic Tissue Antibodies  >145 publications with SMAD4 and Embryonic Tissue
 Kidney Antibodies  >134 publications with SMAD4 and Kidney
 Brain Antibodies  >114 publications with SMAD4 and Brain
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