Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow SMAD6 rightarrow Polyclonal SMAD6  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • AOX1 Antibody
 • ZNF136 Antibody
 • E2F2 Antibody
 • Macrophage Inflammatory Protein 3 Alpha (MIP-3alpha) ELISA Kit
 • Apoptosis repressor with CARD (NOL3) Antibody
 • S3-12 - KIAA1881 Peptide
 • Cholinesterase (BCHE) ELISA Kit
 • Interleukin-22 (IL 22) Recombinant Protein
 • A4GALT siRNA
 • 4-aminobutyrate aminotransferase (Mesop_0044) Antibody
 • CNIH2 Antibody
 • Human IgG1 kappa Isotype Control Isotype Control
 • Gag (Pan) Antibody
 • 14-3-3 protein beta-alpha (YWHAB) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-SMAD6 antibody :: Rabbit anti-Human SMAD6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125675
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMAD6, Polyclonal Antibody

 Also Known As   

SMAD6 Polyclonal Antibody

 Product Synonym Names    Smad6: AOVD2; MADH6; MADH7; HsT17432
 Product Gene Name   

anti-SMAD6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    gene 614823
 3D Structure    ModBase 3D Structure for O43541
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
Section Bar
 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic peptide of human SMAD6
 Calculated Molecular Weight    53kDa
Section Bar
 Preparation and Storage    Store at 4 degree C (regular) or -20 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-SMAD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-SMAD6 antibody

   The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-SMAD6 antibody    Polyclonal
 Applications Tested/Suitable for anti-SMAD6 antibody   

Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-SMAD6 antibody    WB: 1:500 - 1:1000
FC: 1:20 - 1:50
Section Bar
 Western Blot (WB) of anti-SMAD6 antibody    Western blot analysis of extracts of various cell lines, using SMAD6 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 15s.
anti-SMAD6 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SMAD6. It may not necessarily be applicable to this product.
 NCBI GI #    115502451
 NCBI GeneID    4091
 NCBI Accession #    O43541.2 [Other Products]
Section Bar
 UniProt Primary Accession #    O43541 [Other Products]
 UniProt Secondary Accession #    O43654; Q15799; Q7Z7L4; Q96E31; Q9UKZ3; A9J6M5 [Other Products]
 UniProt Related Accession #    O43541 [Other Products]
 Molecular Weight    496
Table BarTOPTable Bar
 NCBI Official Full Name    Mothers against decapentaplegic homolog 6
 NCBI Official Synonym Full Names    SMAD family member 6
 NCBI Official Symbol    SMAD6 [Similar Products]
 NCBI Official Synonym Symbols   
AOVD2; MADH6; MADH7; HsT17432
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 6; MAD homolog 6; SMAD, mothers against DPP homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6
 UniProt Protein Name    Mothers against decapentaplegic homolog 6
 UniProt Synonym Protein Names   
SMAD family member 6; SMAD 6; Smad6; hSMAD6
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD6 [Similar Products]
 UniProt Synonym Gene Names    MADH6; MAD homolog 6; Mothers against DPP homolog 6; SMAD 6; Smad6; hSMAD6 [Similar Products]
 UniProt Entry Name    SMAD6_HUMAN
Section Bar
 NCBI Summary for SMAD6    The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
Section Bar
 UniProt Comments for SMAD6    SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: transcription factor complex; protein complex; cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; ubiquitin protein ligase binding; metal ion binding; chromatin binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transcription factor activity

Biological Process: BMP signaling pathway; fat cell differentiation; negative regulation of cell proliferation; zygotic determination of dorsal/ventral axis; transcription, DNA-dependent; ureteric bud development; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell-substrate adhesion; negative regulation of apoptosis; negative regulation of BMP signaling pathway

Disease: Aortic Valve Disease 2
Table BarTOPTable Bar
 Research Articles on SMAD6    1. Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-SMAD6 antibodyPathways associated with anti-SMAD6 antibody
 Reference Product  PubMed Publications
 SMAD7 antibody  >173 publications with SMAD6 and SMAD7
 SMAD1 antibody  >126 publications with SMAD6 and SMAD1
 SMAD4 antibody  >90 publications with SMAD6 and SMAD4
 SMAD5 antibody  >56 publications with SMAD6 and SMAD5
 BMPR2 antibody  >28 publications with SMAD6 and BMPR2
 SMURF1 antibody  >15 publications with SMAD6 and SMURF1
 SMURF2 antibody  >7 publications with SMAD6 and SMURF2
 HOXC8 antibody  >2 publications with SMAD6 and HOXC8
 TAB1 antibody  >2 publications with SMAD6 and TAB1
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-SMAD6 antibodyOrgans/Tissues associated with anti-SMAD6 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >29 publications with SMAD6 and Fibrosis
 Disease Models, Animal Antibodies  >15 publications with SMAD6 and Disease Models, Animal
 Hypertension Antibodies  >13 publications with SMAD6 and Hypertension
 Inflammation Antibodies  >13 publications with SMAD6 and Inflammation
 Kidney Diseases Antibodies  >12 publications with SMAD6 and Kidney Diseases
 Pancreatic Neoplasms Antibodies  >8 publications with SMAD6 and Pancreatic Neoplasms
 Heart Diseases Antibodies  >8 publications with SMAD6 and Heart Diseases
 Necrosis Antibodies  >8 publications with SMAD6 and Necrosis
 Hypertrophy Antibodies  >7 publications with SMAD6 and Hypertrophy
 Neoplasms, Experimental Antibodies  >7 publications with SMAD6 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >219 publications with SMAD6 and Bone
 Embryonic Tissue Antibodies  >32 publications with SMAD6 and Embryonic Tissue
 Kidney Antibodies  >23 publications with SMAD6 and Kidney
 Heart Antibodies  >21 publications with SMAD6 and Heart
 Lung Antibodies  >17 publications with SMAD6 and Lung
 Connective Tissue Antibodies  >16 publications with SMAD6 and Connective Tissue
 Brain Antibodies  >14 publications with SMAD6 and Brain
 Ovary Antibodies  >12 publications with SMAD6 and Ovary
 Parathyroid Antibodies  >8 publications with SMAD6 and Parathyroid
 Eye Antibodies  >7 publications with SMAD6 and Eye
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions