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anti-SMAD7 antibody :: Rabbit SMAD7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2523702
Unit / Price
0.06 mL  /  $200 +1 FREE 8GB USB
0.12 mL  /  $275 +1 FREE 8GB USB
0.2 mL  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMAD7, Polyclonal Antibody

 Also Known As   

SMAD7 Polyclonal Antibody

 Product Synonym Names    CRCS3, MADH7, MADH8
 Product Gene Name   

anti-SMAD7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602932
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.1mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human SMAD7
 Calculated Molecular Weight: 46kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-SMAD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SMAD7 antibody

   The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-SMAD7 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SMAD7 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western blot of anti-SMAD7 antibody    Western blot analysis of Mouse heart tissue, using SMAD7 Polyclonal Antibody at dilution of 1:1000
anti-SMAD7 antibody Western blot image
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  Immunohistochemistry (IHC) of anti-SMAD7 antibody    Immunohistochemistry of Human liver cancer using SMAD7 Polyclonal Antibody at dilution of 1:60
anti-SMAD7 antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry of anti-SMAD7 antibody    Immunohistochemistry of Human lung cancer using SMAD7 Polyclonal Antibody at dilution of 1:60
anti-SMAD7 antibody Immunohistochemistry  (IHC) image
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NCBI/Uniprot data below describe general gene information for SMAD7. It may not necessarily be applicable to this product.
 NCBI GI #    18418630
 NCBI GeneID    4092
 NCBI Accession #    AAL68977.1 [Other Products]
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 UniProt Secondary Accession #    O14740; Q6DK23; B7Z773; K7EQ10 [Other Products]
 UniProt Related Accession #    O15105 [Other Products]
 Molecular Weight    46,355 Da
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 NCBI Official Full Name    Smad7
 NCBI Official Synonym Full Names    SMAD family member 7
 NCBI Official Symbol    SMAD7 [Similar Products]
 NCBI Official Synonym Symbols   
CRCS3; MADH7; MADH8
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 8; Mothers against decapentaplegic, drosophila, homolog of, 7; SMAD, mothers against DPP homolog 7; hSMAD7; mothers against DPP homolog 8
 UniProt Protein Name    Mothers against decapentaplegic homolog 7
 UniProt Synonym Protein Names   
Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD7 [Similar Products]
 UniProt Synonym Gene Names    MADH7; MADH8; MAD homolog 7; Mothers against DPP homolog 7; MAD homolog 8; Mothers against DPP homolog 8; SMAD 7; Smad7; hSMAD7 [Similar Products]
 UniProt Entry Name    SMAD7_HUMAN
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 NCBI Summary for SMAD7    The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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 UniProt Comments for SMAD7    SMAD7: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber. Belongs to the dwarfin/SMAD family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nucleoplasm; transcription factor complex; protein complex; cell-cell adherens junction; cytoplasm; plasma membrane; catenin complex; nucleus; cytosol

Molecular Function: collagen binding; protein binding; metal ion binding; ubiquitin protein ligase binding; activin binding; beta-catenin binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; protein stabilization; transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; BMP signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; ureteric bud development; positive regulation of protein ubiquitination; transforming growth factor beta receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell-cell adhesion; negative regulation of ubiquitin-protein ligase activity; ventricular cardiac muscle morphogenesis; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of protein ubiquitination; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cell migration

Disease: Colorectal Cancer, Susceptibility To, 3
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 Research Articles on SMAD7    1. Studies indicate that as an inhibitor of transforming growth factor beta (TGF-beta) signaling, SMAD family member 7 (SMAD7) is overexpressed in numerous cancer types and its abundance is positively correlated to the malignancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to SMAD7 Polyclonal Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS9216630  Rabbit Anti-Smad7 + Smad6 Polyclonal Antibody  MBS2501154  Guinea pig Smad7/MADH7 (Mothers Against Decapentaplegic Homolog 7) ELISA Kit
 MBS1155034  Recombinant Rat Mothers against decapentaplegic homolog 7 (Smad7)  MBS2020338  Mothers Against Decapentaplegic Homolog 7 (Smad7) ELISA Kit
 MBS2514083  Mouse Smad7 (Mothers Against Decapentaplegic Homolog 7) ELISA Kit  MBS2531583  Human Smad7/MADH7 (Mothers Against Decapentaplegic Homolog 7) CLIA Kit
 MBS821041  Anti-SMAD7 Antibody  MBS9387605  Smad7 Antibody
 MBS9410243  SMAD7 Antibody  MBS450559  Rat Mothers Against Decapentaplegic Homolog 7 (Smad7) ELISA Kit
Products associated with anti-SMAD7 antibodyPathways associated with anti-SMAD7 antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >541 publications with SMAD7 and TGFB1
 SMAD4 antibody  >293 publications with SMAD7 and SMAD4
 SMURF2 antibody  >60 publications with SMAD7 and SMURF2
 SMURF1 antibody  >32 publications with SMAD7 and SMURF1
 TGFBR1 antibody  >15 publications with SMAD7 and TGFBR1
 BMPR1A antibody  >13 publications with SMAD7 and BMPR1A
 HDAC1 antibody  >4 publications with SMAD7 and HDAC1
 WWP1 antibody  >3 publications with SMAD7 and WWP1
 UBC antibody  >1 publications with SMAD7 and UBC
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with anti-SMAD7 antibodyOrgans/Tissues associated with anti-SMAD7 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >357 publications with SMAD7 and Fibrosis
 Inflammation Antibodies  >137 publications with SMAD7 and Inflammation
 Disease Models, Animal Antibodies  >120 publications with SMAD7 and Disease Models, Animal
 Liver Diseases Antibodies  >101 publications with SMAD7 and Liver Diseases
 Kidney Diseases Antibodies  >101 publications with SMAD7 and Kidney Diseases
 Necrosis Antibodies  >62 publications with SMAD7 and Necrosis
 Cardiovascular Diseases Antibodies  >60 publications with SMAD7 and Cardiovascular Diseases
 Liver Cirrhosis Antibodies  >55 publications with SMAD7 and Liver Cirrhosis
 Adenocarcinoma Antibodies  >54 publications with SMAD7 and Adenocarcinoma
 Colorectal Neoplasms Antibodies  >54 publications with SMAD7 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >213 publications with SMAD7 and Bone
 Muscle Antibodies  >203 publications with SMAD7 and Muscle
 Blood Antibodies  >187 publications with SMAD7 and Blood
 Kidney Antibodies  >180 publications with SMAD7 and Kidney
 Lung Antibodies  >111 publications with SMAD7 and Lung
 Connective Tissue Antibodies  >102 publications with SMAD7 and Connective Tissue
 Vascular Antibodies  >96 publications with SMAD7 and Vascular
 Embryonic Tissue Antibodies  >62 publications with SMAD7 and Embryonic Tissue
 Heart Antibodies  >62 publications with SMAD7 and Heart
 Eye Antibodies  >40 publications with SMAD7 and Eye
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