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anti-SMARCAL1 antibody :: Rabbit anti-Human SMARCAL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240512
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMARCAL1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human SMARCAL1

 Product Synonym Names    Anti-SMARCAL1 Antibody (aa80-96) IHC-plus; SMARCAL1; ATP-driven annealing helicase; HARP; HepA-related protein; HHARP; SMARCA-like protein 1; SIOD; Human SMARCAL1
 Product Gene Name   

anti-SMARCAL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 606622
 3D Structure    ModBase 3D Structure for Q9NZC9
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    aa 80-96 of human SmarcAL1 protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human SMARCAL1.
 Immunogen Type    Synthetic peptide
 Immunogen    SMARCAL1 antibody was raised against synthetic peptide from human SMARCAL1.
 Antigen Modification    aa80-96
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-SMARCAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SMARCAL1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SMARCAL1 antibody    ELISA (1:16000 - 1:64000), IHC-P (5 ug/ml), WB (1:500 - 1:3000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-SMARCAL1 antibody    Anti-SMARCAL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-SMARCAL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SMARCAL1 antibody    Anti-SmarcAL1 Antibody - Western Blot. Western blot of Affinity Purified anti-SmarcAL1 antibody shows detection of a band ~106 kD band (arrowhead) corresponding to SmarcAL1 in human derived cultured cell lysates (HeLa nuclear extract lane 1, HeLa lane 2, A431 lane 3, Jurkat lane 4, and 293 lane 5). Approximately 5 ug of each lysates was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-SmarcAL1 antibody. Signal was detected using standard techniques. SmarcAL1 is the band seen between the 97 and 116kD markers.
anti-SMARCAL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SMARCAL1. It may not necessarily be applicable to this product.
 NCBI GI #    21071060
 NCBI GeneID    50485
 NCBI Accession #    NP_054859.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014140.3 [Other Products]
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 UniProt Primary Accession #    Q9NZC9 [Other Products]
 UniProt Secondary Accession #    Q53R00; Q96AY1; Q9NXQ5; Q9UFH3; Q9UI93; A6NEH0 [Other Products]
 UniProt Related Accession #    Q9NZC9 [Other Products]
 Molecular Weight    105,938 Da
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 NCBI Official Full Name    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
 NCBI Official Synonym Full Names    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
 NCBI Official Symbol    SMARCAL1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; HepA-related protein; SMARCA-like protein 1; ATP-driven annealing helicase; sucrose nonfermenting protein 2-like 1
 UniProt Protein Name    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
 UniProt Synonym Protein Names   
HepA-related protein; hHARP; Sucrose nonfermenting protein 2-like 1
 UniProt Gene Name    SMARCAL1 [Similar Products]
 UniProt Synonym Gene Names    HARP; hHARP [Similar Products]
 UniProt Entry Name    SMAL1_HUMAN
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 NCBI Summary for SMARCAL1    The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SMARCAL1    SMARCAL1: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.

Protein type: EC 3.6.4.-; Helicase; EC 3.6.1.-

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus

Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; helicase activity; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; DNA strand renaturation; chromatin modification; DNA repair; response to DNA damage stimulus; DNA metabolic process; replication fork processing

Disease: Immunoosseous Dysplasia, Schimke Type
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 Research Articles on SMARCAL1    1. We present here the first evidence of intrinsic chromosomal instability in a severe SMARCAL1-deficient patient with a clinical picture of SIOD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-SMARCAL1 antibodyOrgans/Tissues associated with anti-SMARCAL1 antibody
 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >34 publications with SMARCAL1 and Musculoskeletal Diseases
 Kidney Diseases Antibodies  >20 publications with SMARCAL1 and Kidney Diseases
 Schimke immunoosseous dysplasia Antibodies  >19 publications with SMARCAL1 and Schimke immunoosseous dysplasia
 Cardiovascular Diseases Antibodies  >15 publications with SMARCAL1 and Cardiovascular Diseases
 Neutropenia Antibodies  >4 publications with SMARCAL1 and Neutropenia
 Atherosclerosis Antibodies  >3 publications with SMARCAL1 and Atherosclerosis
 Nephritis Antibodies  >3 publications with SMARCAL1 and Nephritis
 Abnormalities, Multiple Antibodies  >2 publications with SMARCAL1 and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >1 publications with SMARCAL1 and Disease Models, Animal
 Abnormalities, Drug-Induced Antibodies  >1 publications with SMARCAL1 and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with SMARCAL1 and Blood
 Kidney Antibodies  >8 publications with SMARCAL1 and Kidney
 Vascular Antibodies  >7 publications with SMARCAL1 and Vascular
 Bone Marrow Antibodies  >4 publications with SMARCAL1 and Bone Marrow
 Brain Antibodies  >4 publications with SMARCAL1 and Brain
 Muscle Antibodies  >3 publications with SMARCAL1 and Muscle
 Lung Antibodies  >2 publications with SMARCAL1 and Lung
 Heart Antibodies  >2 publications with SMARCAL1 and Heart
 Thymus Antibodies  >2 publications with SMARCAL1 and Thymus
 Testis Antibodies  >2 publications with SMARCAL1 and Testis
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