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anti-SMO antibody :: Goat SMO Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420961
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMO, Polyclonal Antibody

 Also Known As   

Goat anti-SMO (internal) Antibody

 Product Synonym Names    Goat Anti-SMO (C Terminus) Antibody; SMO; smoothened homolog (Drosophila); Gx; SMOH; seven transmembrane helix receptor; smoothened; SMO antibody; smoothened homolog (Drosophila) antibody; Gx antibody; SMOH antibody; seven transmembrane helix receptor antibody; smoothened antibody; SMO (internal)
 Product Gene Name   

anti-SMO antibody

[Similar Products]
 Antibody/Peptide Pairs    SMO peptide (MBS426743) is used for blocking the activity of SMO antibody (MBS420961)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QSDDEPKRIK KS
 OMIM    601500
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Zebrafish
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QSDDEPKRIKKS, from the internal region of the protein sequence according to NP_005622.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SMO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SMO antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SMO antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Approx 60kDa band observed in Human Bone Marrow lysates (calculated MW of 86.4kDa according to NP_005622.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-SMO antibody    A) and B) (0.3ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SMO antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SMO. It may not necessarily be applicable to this product.
 NCBI GI #    5032099
 NCBI GeneID    6608
 NCBI Accession #    NP_005622.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005631.4 [Other Products]
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 UniProt Secondary Accession #    A4D1K5 [Other Products]
 UniProt Related Accession #    Q99835 [Other Products]
 Molecular Weight    86,397 Da
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 NCBI Official Full Name    smoothened homolog
 NCBI Official Synonym Full Names    smoothened, frizzled class receptor
 NCBI Official Symbol    SMO [Similar Products]
 NCBI Official Synonym Symbols   
Gx; SMOH; FZD11
[Similar Products]
 NCBI Protein Information    smoothened homolog
 UniProt Protein Name    Smoothened homolog
 UniProt Synonym Protein Names   
Protein Gx
 Protein Family    Smoothelin
 UniProt Gene Name    SMO [Similar Products]
 UniProt Synonym Gene Names    SMOH; SMO [Similar Products]
 UniProt Entry Name    SMO_HUMAN
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 NCBI Summary for SMO    The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
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 UniProt Comments for SMO    SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Receptor, GPCR; Oncoprotein; GPCR, Fz/Smo family; Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q32.3

Cellular Component: caveola; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: drug binding; G-protein coupled receptor activity; patched binding; protein binding; Wnt receptor activity; Wnt-protein binding

Biological Process: activation of hh target transcription factor; anterior/posterior pattern formation; astrocyte activation; cell fate specification; central nervous system neuron differentiation; cerebellar cortex morphogenesis; cerebral cortex development; dentate gyrus development; dorsoventral neural tube patterning; forebrain morphogenesis; G-protein coupled receptor protein signaling pathway; hair follicle morphogenesis; heart looping; homeostasis of number of cells within a tissue; in utero embryonic development; midgut development; multicellular organism growth; myoblast migration; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of epithelial cell differentiation; negative regulation of hair follicle development; negative regulation of transcription from RNA polymerase II promoter; neural crest cell migration; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of organ growth; positive regulation of protein import into nucleus; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; skeletal muscle fiber development; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; smoothened signaling pathway in ventral spinal cord patterning; thalamus development; vasculogenesis; ventral midline determination; Wnt receptor signaling pathway through beta-catenin
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 Research Articles on SMO    1. Recipient SMO rs3824 polymorphism is associated with an increased risk of hepatocellular carcinoma recurrence following orthotopic liver transplantation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SMO antibodyPathways associated with anti-SMO antibody
 Reference Product  PubMed Publications
 SHH antibody  >502 publications with SMO and SHH
 GLI1 antibody  >407 publications with SMO and GLI1
 PTCH1 antibody  >233 publications with SMO and PTCH1
 GLI2 antibody  >163 publications with SMO and GLI2
 GLI3 antibody  >85 publications with SMO and GLI3
 SUFU antibody  >80 publications with SMO and SUFU
 IHH antibody  >76 publications with SMO and IHH
 PTCH2 antibody  >20 publications with SMO and PTCH2
 RAB23 antibody  >11 publications with SMO and RAB23
 ARRB2 antibody  >3 publications with SMO and ARRB2
 Products by Pathway  Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BBSome-mediated Cargo-targeting To Cilium Pathway antibodies  BBSome-mediated Cargo-targeting To Cilium Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-SMO antibodyOrgans/Tissues associated with anti-SMO antibody
 Disease Name  Pubmed Publications
 Carcinoma, Basal Cell Antibodies  >176 publications with SMO and Carcinoma, Basal Cell
 Skin Neoplasms Antibodies  >81 publications with SMO and Skin Neoplasms
 Neuroectodermal Tumors, Primitive Antibodies  >76 publications with SMO and Neuroectodermal Tumors, Primitive
 Disease Models, Animal Antibodies  >66 publications with SMO and Disease Models, Animal
 Brain Neoplasms Antibodies  >66 publications with SMO and Brain Neoplasms
 Neoplasms, Experimental Antibodies  >40 publications with SMO and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >32 publications with SMO and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >30 publications with SMO and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >28 publications with SMO and Cardiovascular Diseases
 Liver Diseases Antibodies  >28 publications with SMO and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >172 publications with SMO and Brain
 Skin Antibodies  >126 publications with SMO and Skin
 Bone Antibodies  >122 publications with SMO and Bone
 Embryonic Tissue Antibodies  >116 publications with SMO and Embryonic Tissue
 Muscle Antibodies  >73 publications with SMO and Muscle
 Lung Antibodies  >62 publications with SMO and Lung
 Prostate Antibodies  >38 publications with SMO and Prostate
 Bone Marrow Antibodies  >38 publications with SMO and Bone Marrow
 Connective Tissue Antibodies  >30 publications with SMO and Connective Tissue
 Pancreas Antibodies  >29 publications with SMO and Pancreas
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