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anti-SNAP23 antibody :: Goat SNAP23 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422518
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SNAP23, Polyclonal Antibody

 Also Known As   

Goat anti-SNAP23 (aa 135-144) Antibody

 Product Synonym Names    Goat Anti-SNAP23 Antibody; SNAP23; synaptosomal-associated protein, 23kDa; HsT17016; SNAP23A; SNAP23B; OTTHUMP00000161263; synaptosomal-associated protein 23; HsT17016 antibody; OTTHUMP00000161263 antibody; SNAP23A antibody; SNAP23B antibody; synaptosomal-associated protein 23 antibody; synaptosomal-associated protein; 23kDa antibody; SNAP23 antibody; SNAP23 (aa 135-144)
 Product Gene Name   

anti-SNAP23 antibody

[Similar Products]
 Antibody/Peptide Pairs    SNAP23 peptide (MBS427993) is used for blocking the activity of SNAP23 antibody (MBS422518)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TDKADTNRDR
 OMIM    602534
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Rabbit
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TDKADTNRDR, from the C Terminus of the protein sequence according to NP_003816.2; NP_570710.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognize both isoforms (NP_003816.2; NP_570710.1). Amino acid numbering in name refers to NP_003816.2 sequence.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SNAP23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SNAP23 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SNAP23 antibody    Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Approx 20+26kDa bands observed in Human Peripheral Blood Mononucleocytes lysates (calculated MW of 17.8kDa according to NP_570710.1 and of 23.4kDa according to NP_003816.2). Recommended concentration: 0.2-0.6ug/ml.
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 Western Blot (WB) of anti-SNAP23 antibody    (0.2ug/ml) staining of PBMC lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SNAP23 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SNAP23. It may not necessarily be applicable to this product.
 NCBI GI #    18765729
 NCBI GeneID    8773
 NCBI Accession #    NP_003816.2 [Other Products]
 NCBI Related Accession #    NP_570710.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003825.3 [Other Products]
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 UniProt Secondary Accession #    O00162; Q13602; Q6IAE3 [Other Products]
 UniProt Related Accession #    O00161 [Other Products]
 Molecular Weight    17,789 Da
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 NCBI Official Full Name    synaptosomal-associated protein 23 isoform SNAP23A
 NCBI Official Synonym Full Names    synaptosome associated protein 23kDa
 NCBI Official Symbol    SNAP23 [Similar Products]
 NCBI Official Synonym Symbols   
SNAP-23; SNAP23A; SNAP23B; HsT17016
[Similar Products]
 NCBI Protein Information    synaptosomal-associated protein 23
 UniProt Protein Name    Synaptosomal-associated protein 23
 UniProt Synonym Protein Names   
Vesicle-membrane fusion protein SNAP-23
 Protein Family    Synaptosomal-associated protein
 UniProt Gene Name    SNAP23 [Similar Products]
 UniProt Synonym Gene Names    SNAP-23 [Similar Products]
 UniProt Entry Name    SNP23_HUMAN
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 NCBI Summary for SNAP23    Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SNAP23    SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: azurophil granule; cytoplasm; focal adhesion; mast cell granule; neuron projection; nucleoplasm; plasma membrane; SNARE complex; specific granule

Molecular Function: protein binding; SNAP receptor activity; syntaxin binding

Biological Process: histamine secretion by mast cell; post-Golgi vesicle-mediated transport; protein transport; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle priming; vesicle targeting
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 Research Articles on SNAP23    1. these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNAP23 antibodyPathways associated with anti-SNAP23 antibody
 Reference Product  PubMed Publications
 VAMP2 antibody  >50 publications with SNAP23 and VAMP2
 VAMP3 antibody  >32 publications with SNAP23 and VAMP3
 VAMP8 antibody  >21 publications with SNAP23 and VAMP8
 VAMP7 antibody  >15 publications with SNAP23 and VAMP7
 STXBP3 antibody  >10 publications with SNAP23 and STXBP3
 STX4 antibody  >7 publications with SNAP23 and STX4
 VAMP1 antibody  >5 publications with SNAP23 and VAMP1
 STX3 antibody  >3 publications with SNAP23 and STX3
 STX2 antibody  >2 publications with SNAP23 and STX2
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 Translocation Of GLUT4 To The Plasma Membrane Pathway antibodies  Translocation Of GLUT4 To The Plasma Membrane Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
Diseases associated with anti-SNAP23 antibodyOrgans/Tissues associated with anti-SNAP23 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12 publications with SNAP23 and Inflammation
 Necrosis Antibodies  >8 publications with SNAP23 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with SNAP23 and Disease Models, Animal
 Fibrosis Antibodies  >5 publications with SNAP23 and Fibrosis
 Diabetes Mellitus Antibodies  >5 publications with SNAP23 and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >4 publications with SNAP23 and Cardiovascular Diseases
 Hypertension Antibodies  >4 publications with SNAP23 and Hypertension
 Liver Diseases Antibodies  >2 publications with SNAP23 and Liver Diseases
 Hemorrhage Antibodies  >1 publications with SNAP23 and Hemorrhage
 Carcinoma, Hepatocellular Antibodies  >1 publications with SNAP23 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with SNAP23 and Blood
 Muscle Antibodies  >38 publications with SNAP23 and Muscle
 Brain Antibodies  >25 publications with SNAP23 and Brain
 Kidney Antibodies  >15 publications with SNAP23 and Kidney
 Lung Antibodies  >13 publications with SNAP23 and Lung
 Pancreas Antibodies  >11 publications with SNAP23 and Pancreas
 Vascular Antibodies  >9 publications with SNAP23 and Vascular
 Liver Antibodies  >8 publications with SNAP23 and Liver
 Bone Antibodies  >7 publications with SNAP23 and Bone
 Intestine Antibodies  >6 publications with SNAP23 and Intestine
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