NP_001257504.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
synaptosomal-associated protein 25 isoform a
NCBI Official Synonym Full Names
synaptosomal-associated protein 25
NCBI Protein Information
synaptosomal-associated protein 25; SUP; SNAP-25; super protein; synaptosomal-associated 25 kDa protein; synaptosomal-associated protein, 25 kDa
UniProt Protein Name
Synaptosomal-associated protein 25
UniProt Synonym Protein Names
Super protein; SUP; Synaptosomal-associated 25 kDa protein
UniProt Synonym Gene Names
UniProt Entry Name
SNP25_RAT
NCBI Summary for SNAP25
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein. It is essential for regulated exocytosis in neuronal cells. Alternative transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for SNAP25
Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Subunit structure: Interacts with CENP and OTOF. Found in a complex containing SYT1, SV2B and syntaxin-1. Associates with the BLOC-1 complex. Isoform 1 and isoform 2 interact with BLOC1S6
By similarity. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with TRIM9, RIMS1, SNAPIN, and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Interacts with EQTN
By similarity. Ref.9 Ref.10 Ref.11 Ref.12
Subcellular location: Cytoplasm › perinuclear region
By similarity. Cell membrane; Lipid-anchor. Cell junction › synapse › synaptosome. Note: Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region
By similarity. Ref.6 Ref.8
Post-translational modification: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association
By similarity. Ref.6
Sequence similarities: Belongs to the SNAP-25 family.Contains 2 t-SNARE coiled-coil homology domains.
Product References and Citations for anti-SNAP25 antibody
• Ando K, Kudo Y, Takahashi M (2005) Negative regulation of neurotransmitter release by calpain: a possible specific involvement of Snap25 cleavage. J Neurochem 94(3):651-8. • Fatemi SH, Earle JA, Stary JM, Lee S, Sedgwick J (2001) Altered levels of the synaptosomal associated protein Snap25 in hippocampus of patients with mood disorders and Schizophrenia. Neuroreport. 12(15): 3257-62. • Fatemi SH, Sidwell R, Kist D, Akhter P, Meltzer HY, Bailey K, Thuras P, Sedgwick J (1998) Differential expression of synaptosome-associated protein 25 kDa (Snap25) in hippocampi of neonatal mice following exposure to human influenza virus in utero. Brain Res 800(1):1-9. • Greber S, Cairns N, Lubec G, Fountoulakis M (1999) Decreased levels of the synaptosomal associated protein 25 in the brains of patients with Down Syndrome and Alzheimer's Disease. Electrophoresis 20 (4-5):928-34. • Pozzi D, Condliffe S, Bozzi Y, Chikhladze M, Grumelli C, Proux-Gillardeaux V, Takahashi M, Franceschetti S, Verderio C, Matteoli M (2008) Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels. PNAS 105: 323-328.
Research Articles on SNAP25
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Pathways associated with anti-SNAP25 antibody
Diseases associated with anti-SNAP25 antibody
Organs/Tissues associated with anti-SNAP25 antibody
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