NP_067072.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,570 Da
NCBI Official Full Name
sorting nexin-6 isoform a
NCBI Official Synonym Full Names
sorting nexin 6
NCBI Protein Information
sorting nexin-6
UniProt Protein Name
Sorting nexin-6
UniProt Synonym Protein Names
TRAF4-associated factor 2
UniProt Entry Name
SNX6_HUMAN
NCBI Summary for SNX6
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for SNX6
SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. Belongs to the sorting nexin family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 14q13.1
Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; early endosome membrane; extrinsic to membrane; intracellular; nucleus; retromer complex
Molecular Function: phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: endocytosis; intracellular protein transport; negative regulation of epidermal growth factor receptor activity; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; retrograde transport, endosome to Golgi; vesicle organization and biogenesis
Research Articles on SNX6
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Products associated with anti-SNX6 antibody
Pathways associated with anti-SNX6 antibody
Diseases associated with anti-SNX6 antibody
Organs/Tissues associated with anti-SNX6 antibody
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