Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow SOCS-1 rightarrow Polyclonal SOCS-1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • MAN2A1 Peptide
 • Adenosine A2a Receptor (ADORA2a) ELISA Kit
 • Cyclooxygenase 2 (COX2) ELISA Kit
 • S100 Calcium Binding Protein P (S100P) Recombinant Protein
 • LAT1 Antibody
 • ATM Antibody
 • CD119 Antibody
 • Integration host factor subunit alpha (ihfA) Recombinant Protein
 • A Disintegrin Like and Metalloproteinase With Thrombospondin... ELISA Kit
 • acyl-Coenzyme A dehydrogenase family, member 8 (ACAD8) Antibody
 • N epsilon-Palmitoyl-L-glutami c Acid gamma-Succinimidyl- alph... Biochemical
 • Endotoxin (EDT) ELISA Kit
 • amyloid beta peptide 1-40 (Abeta1-40) ELISA Kit
 • Annexin XI (ANN-XI) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-SOCS-1 antibody :: Rabbit anti-Mouse, Rat SOCS-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221493
Testing Data #1
Unit / Price
0.1 mg  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOCS-1, Polyclonal Antibody

★Popular Item★
 Also Known As   

RABBIT ANTI SOCS-1 (C-TERMINAL)

 Product Gene Name   

anti-SOCS-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603597
 3D Structure    ModBase 3D Structure for O15524
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
Section Bar
 Specificity    This item recognises Suppressor of cytokine signalling 1 (SOCS1), a 24kDa member of the Suppressor of cytokine signalling family. SOCS1 acts downstream of cytokine receptors and plays a role in the negative regulation of cytokine signalling. It acts mainly on the Janus kinase (JAK)/signal transducers and activators of transcription-3 (STAT3) pathway but also inhibits signalling by cytokines such as insulin and toll-like receptors. Furthermore SOCS1 is involved in ubiquitin-dependent protein degradation, plays a role in T cell activation and in the regulation of IL-6, IL-4, IL-12 and IL-15. SOCS1 is expressed ubiquitously and at elevated levels in the spleen, small intestine and peripheral blood leukocytes.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
Section Bar
 Perservative Stabilisers    0.02% Sodium Azide
Preparation
 Immunogen    A 15 amino acid peptide located near the carboxy terminus of human SOCS1.
Buffer Solution
 Target Species    Human
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-SOCS-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-SOCS-1 antibody

   MBS221493 recognises Suppressor of cytokine signalling 1 (SOCS1), a 24kDa member of the Suppressor of cytokine signalling family. SOCS1 acts downstream of cytokine receptors and plays a role in the negative regulation of cytokine signalling. It acts mainly on the Janus kinase (JAK)/signal transducers and activators of transcription-3 (STAT3) pathway but also inhibits signalling by cytokines such as insulin and toll-like receptors. Furthermore SOCS1 is involved in ubiquitin-dependent protein degradation, plays a role in T cell activation and in the regulation of IL-6, IL-4, IL-12 and IL-15. SOCS1 is expressed ubiquitously and at elevated levels in the spleen, small intestine and peripheral blood leukocytes.
 Applications Tested/Suitable for anti-SOCS-1 antibody   

Western Blot (WB)

 Application Notes for anti-SOCS-1 antibody    Western Blot: This item detects a bands of approximately 1.0-23.0ug/ml in human spleen cell lysates.
Western Blotting: Minimum Dilution: 1.0; Maximum Dilution: 2.0ug/ml
Section Bar
 Testing Data #1 of anti-SOCS-1 antibody    Western blot analysis of human spleen lysate probed with Rabbit anti Human SOCS-1 (MBS221493) at 1(A), 2(B) and 4(C) ug/ml
anti-SOCS-1 antibody Testing Data #1 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SOCS-1. It may not necessarily be applicable to this product.
 NCBI GI #    4507233
 NCBI GeneID    8651
 NCBI Accession #    NP_003736.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003745.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O15524 [Other Products]
 UniProt Secondary Accession #    O15097; Q9NSA7 [Other Products]
 UniProt Related Accession #    O15524 [Other Products]
 Molecular Weight    23,551 Da
Table BarTOPTable Bar
 NCBI Official Full Name    suppressor of cytokine signaling 1
 NCBI Official Synonym Full Names    suppressor of cytokine signaling 1
 NCBI Official Symbol    SOCS1 [Similar Products]
 NCBI Official Synonym Symbols   
JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1
[Similar Products]
 NCBI Protein Information    suppressor of cytokine signaling 1; JAK binding protein; JAK-binding protein; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; TIP-3; Tec-interacting protein 3; cytokine-inducible SH2 protein 1
 UniProt Protein Name    Suppressor of cytokine signaling 1
 UniProt Synonym Protein Names   
JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3
 UniProt Gene Name    SOCS1 [Similar Products]
 UniProt Synonym Gene Names    SSI1; TIP3; SOCS-1; JAB; SSI-1; TIP-3 [Similar Products]
 UniProt Entry Name    SOCS1_HUMAN
Section Bar
 NCBI Summary for SOCS-1    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for SOCS-1    SOCS1: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR. By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families. Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasm; nucleus; cytosol

Molecular Function: insulin-like growth factor receptor binding; protein binding; protein kinase inhibitor activity; kinase inhibitor activity; protein kinase binding

Biological Process: fat cell differentiation; regulation of protein amino acid phosphorylation; regulation of growth; cytokine and chemokine mediated signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of insulin receptor signaling pathway; negative regulation of protein kinase activity; protein ubiquitination; JAK-STAT cascade; negative regulation of JAK-STAT cascade
Table BarTOPTable Bar
 Research Articles on SOCS-1    1. this proof-of-principle study suggested that methylation of SOCS-1 can be detected in serum of HLA-B27+ AS patients but not in B27+ controls. The pathogenic potential of SOCS-1 methylation in AS deserves further investigation.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-SOCS-1 antibodyPathways associated with anti-SOCS-1 antibody
 Reference Product  PubMed Publications
 STAT1 antibody  >238 publications with SOCS-1 and STAT1
 JAK2 antibody  >165 publications with SOCS-1 and JAK2
 JAK1 antibody  >76 publications with SOCS-1 and JAK1
 STAT6 antibody  >52 publications with SOCS-1 and STAT6
 RELA antibody  >8 publications with SOCS-1 and RELA
 IRS2 antibody  >5 publications with SOCS-1 and IRS2
 VAV1 antibody  >2 publications with SOCS-1 and VAV1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
Diseases associated with anti-SOCS-1 antibodyOrgans/Tissues associated with anti-SOCS-1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >249 publications with SOCS-1 and Inflammation
 Necrosis Antibodies  >129 publications with SOCS-1 and Necrosis
 Liver Diseases Antibodies  >96 publications with SOCS-1 and Liver Diseases
 Disease Models, Animal Antibodies  >93 publications with SOCS-1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >60 publications with SOCS-1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >56 publications with SOCS-1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >55 publications with SOCS-1 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >52 publications with SOCS-1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >48 publications with SOCS-1 and Liver Neoplasms
 Lung Diseases Antibodies  >39 publications with SOCS-1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >90 publications with SOCS-1 and Bone
 Lung Antibodies  >59 publications with SOCS-1 and Lung
 Muscle Antibodies  >52 publications with SOCS-1 and Muscle
 Spleen Antibodies  >47 publications with SOCS-1 and Spleen
 Kidney Antibodies  >45 publications with SOCS-1 and Kidney
 Brain Antibodies  >43 publications with SOCS-1 and Brain
 Skin Antibodies  >41 publications with SOCS-1 and Skin
 Heart Antibodies  >41 publications with SOCS-1 and Heart
 Pancreas Antibodies  >40 publications with SOCS-1 and Pancreas
 Thymus Antibodies  >36 publications with SOCS-1 and Thymus
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions