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anti-SOCS7 antibody :: Rabbit anti-Human, Rat SOCS7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052417
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOCS7, Polyclonal Antibody

★Popular Item★
 Also Known As   

SOCS7 Antibody

 Product Synonym Names    Suppressor of cytokine signaling 7; SOCS-7; Nck; Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4; SOCS7; NAP4; SOCS6
 Product Gene Name   

anti-SOCS7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB005216 mRNA
 3D Structure    ModBase 3D Structure for O14512
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Suppressor of cytokine signaling 7 protein (6-165AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SOCS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SOCS7 antibody

   Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
 Applications Tested/Suitable for anti-SOCS7 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-SOCS7 antibody    WB: 1:500-1:5000
IF: 1:50-1:200
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 Western Blot (WB) of anti-SOCS7 antibody    Western Blot
Positive WB detected in: MCF-7 whole cell lysate,Hela whole cell lysate,Jurkat whole cell lysate,U87 whole cell lysate,Rat heart tissue,Rat liver tissue
All lanes: SOCS7 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63,38 KDa
Observed band size: 63 KDa

anti-SOCS7 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-SOCS7 antibody    Immunofluorescent analysis of HepG2 cells using MBS7052417 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SOCS7 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for SOCS7. It may not necessarily be applicable to this product.
 NCBI GI #    53831997
 NCBI GeneID    30837
 NCBI Accession #    NP_055413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014598.3 [Other Products]
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 UniProt Primary Accession #    O14512 [Other Products]
 UniProt Secondary Accession #    Q0IJ63; A2VCU2 [Other Products]
 UniProt Related Accession #    O14512 [Other Products]
 Molecular Weight    37,461 Da
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 NCBI Official Full Name    suppressor of cytokine signaling 7
 NCBI Official Synonym Full Names    suppressor of cytokine signaling 7
 NCBI Official Symbol    SOCS7 [Similar Products]
 NCBI Official Synonym Symbols   
NAP4; NCKAP4
[Similar Products]
 NCBI Protein Information    suppressor of cytokine signaling 7
 UniProt Protein Name    Suppressor of cytokine signaling 7
 UniProt Synonym Protein Names   
Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4
 Protein Family    Suppressor of cytokine signaling
 UniProt Gene Name    SOCS7 [Similar Products]
 UniProt Synonym Gene Names    NAP4; SOCS6; SOCS-7; NAP-4 [Similar Products]
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 UniProt Comments for SOCS7    SOCS7: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity
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 Research Articles on SOCS7    1. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SOCS7 antibodyDiseases associated with anti-SOCS7 antibody
 Products by Pathway  Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 JAK-STAT Signaling Pathway antibodies  JAK-STAT Signaling Pathway Diagram
 JAK-STAT Signaling Pathway antibodies  JAK-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with SOCS7 and Inflammation
 Liver Diseases Antibodies  >5 publications with SOCS7 and Liver Diseases
 Nervous System Diseases Antibodies  >4 publications with SOCS7 and Nervous System Diseases
 Liver Neoplasms Antibodies  >3 publications with SOCS7 and Liver Neoplasms
 Necrosis Antibodies  >3 publications with SOCS7 and Necrosis
 Disease Models, Animal Antibodies  >1 publications with SOCS7 and Disease Models, Animal
 Fibrosis Antibodies  >1 publications with SOCS7 and Fibrosis
 Fatty Liver Antibodies  >1 publications with SOCS7 and Fatty Liver
 Hyperplasia Antibodies  >1 publications with SOCS7 and Hyperplasia
Organs/Tissues associated with anti-SOCS7 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with SOCS7 and Blood
 Liver Antibodies  >8 publications with SOCS7 and Liver
 Muscle Antibodies  >4 publications with SOCS7 and Muscle
 Brain Antibodies  >4 publications with SOCS7 and Brain
 Lung Antibodies  >3 publications with SOCS7 and Lung
 Prostate Antibodies  >2 publications with SOCS7 and Prostate
 Mammary Gland Antibodies  >2 publications with SOCS7 and Mammary Gland
 Bone Antibodies  >2 publications with SOCS7 and Bone
 Embryonic Tissue Antibodies  >1 publications with SOCS7 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with SOCS7 and Pancreas
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