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anti-SOD2 antibody :: Rabbit anti-Human, mouse SOD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002071
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOD2, Polyclonal Antibody

★Popular Item★
 Also Known As   

SOD2 Antibody

 Product Synonym Names    Superoxide dismutase [Mn]; mitochondrial; SOD2
 Product Gene Name   

anti-SOD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147460
 3D Structure    ModBase 3D Structure for P04179
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Superoxide dismutase [Mn], mitochondrial protrin (64-175AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18503 / sc-18504 / sc-30080
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SOD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SOD2 antibody

   Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
 Applications Tested/Suitable for anti-SOD2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SOD2 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-SOD2 antibody    Western blot
All lanes: SOD2 antibody at 2ug/ml
Lane 1:Hela whole cell lysate
Lane 2:mouse liver tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 25,21,19,20 kDa
Observed band size: 25 kDa

anti-SOD2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-SOD2 antibody    Western blot
All lanes: SOD2 antibody at 4 ug/ml
Lane 1: HepG-2 whole cell lysate
Lane 2: Mouse heart tissue
Lane 3: Mouse liver tissue
Lane 4: Mouse lung tissue
Lane 5: Mouse kidney tissue
Lane 6: Mouse brain tissue
Lane 7: Mouse skeletal muscle tissue
Lane 8: Mouse thymus tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 25,21,19,20 kDa
Observed band size: 24 kDa

anti-SOD2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SOD2 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7002071 at dilution 1:100
anti-SOD2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SOD2. It may not necessarily be applicable to this product.
 NCBI GI #    67782305
 NCBI GeneID    6648
 NCBI Accession #    NP_000627.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000636.2 [Other Products]
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 UniProt Primary Accession #    P04179 [Other Products]
 UniProt Secondary Accession #    P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3; B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9 [Other Products]
 UniProt Related Accession #    P04179 [Other Products]
 Molecular Weight    19,730 Da
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 NCBI Official Full Name    superoxide dismutase
 NCBI Official Synonym Full Names    superoxide dismutase 2, mitochondrial
 NCBI Official Symbol    SOD2 [Similar Products]
 NCBI Official Synonym Symbols   
IPOB; MNSOD; MVCD6
[Similar Products]
 NCBI Protein Information    superoxide dismutase [Mn], mitochondrial
 UniProt Protein Name    Superoxide dismutase [Mn], mitochondrial
 Protein Family    Superoxide dismutase
 UniProt Gene Name    SOD2 [Similar Products]
 UniProt Entry Name    SODM_HUMAN
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 NCBI Summary for SOD2    This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOD2    SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.15.1.1; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: identical protein binding; manganese ion binding; superoxide dismutase activity

Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; negative regulation of cell proliferation; negative regulation of neuron apoptosis; oxygen homeostasis; protein homotetramerization; regulation of blood pressure; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to reactive oxygen species; response to superoxide; superoxide metabolic process

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6
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 Research Articles on SOD2    1. c.47T>C polymorphism (SNP rs4880) in the manganese superoxide dismutase (SOD2) gene is a risk factor for primary angle closure glaucoma (PACG) in the Saudi population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOD2 antibodyPathways associated with anti-SOD2 antibody
 Reference Product  PubMed Publications
 SOD1 antibody  >469 publications with SOD2 and SOD1
 CAT antibody  >196 publications with SOD2 and CAT
 GPX1 antibody  >140 publications with SOD2 and GPX1
 SOD3 antibody  >100 publications with SOD2 and SOD3
 SIRT1 antibody  >33 publications with SOD2 and SIRT1
 FOXO1 antibody  >22 publications with SOD2 and FOXO1
 FOXO3 antibody  >22 publications with SOD2 and FOXO3
 TXN2 antibody  >9 publications with SOD2 and TXN2
 AKT1 antibody  >8 publications with SOD2 and AKT1
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Longevity Regulating Pathway - Mammal antibodies  Longevity Regulating Pathway - Mammal Diagram
 Longevity Regulating Pathway - Multiple Species antibodies  Longevity Regulating Pathway - Multiple Species Diagram
 Longevity Regulating Pathway - Multiple Species antibodies  Longevity Regulating Pathway - Multiple Species Diagram
Diseases associated with anti-SOD2 antibodyOrgans/Tissues associated with anti-SOD2 antibody
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >146 publications with SOD2 and Central Nervous System Diseases
 Vascular Diseases Antibodies  >123 publications with SOD2 and Vascular Diseases
 Mitochondrial Diseases Antibodies  >121 publications with SOD2 and Mitochondrial Diseases
 Neurodegenerative Diseases Antibodies  >92 publications with SOD2 and Neurodegenerative Diseases
 Carcinoma Antibodies  >82 publications with SOD2 and Carcinoma
 Skin Diseases Antibodies  >78 publications with SOD2 and Skin Diseases
 Lung Diseases Antibodies  >61 publications with SOD2 and Lung Diseases
 Breast Neoplasms Antibodies  >59 publications with SOD2 and Breast Neoplasms
 Hypertension Antibodies  >50 publications with SOD2 and Hypertension
 Adenocarcinoma Antibodies  >41 publications with SOD2 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >257 publications with SOD2 and Blood
 Brain Antibodies  >195 publications with SOD2 and Brain
 Liver Antibodies  >172 publications with SOD2 and Liver
 Muscle Antibodies  >162 publications with SOD2 and Muscle
 Lung Antibodies  >112 publications with SOD2 and Lung
 Heart Antibodies  >111 publications with SOD2 and Heart
 Vascular Antibodies  >106 publications with SOD2 and Vascular
 Kidney Antibodies  >72 publications with SOD2 and Kidney
 Nerve Antibodies  >68 publications with SOD2 and Nerve
 Eye Antibodies  >56 publications with SOD2 and Eye
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