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anti-SORBS1 antibody :: Goat SORBS1/Ponsin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421322
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SORBS1/Ponsin, Polyclonal Antibody

 Also Known As   

Goat anti-SORBS1/Ponsin (C Terminus) Antibody

 Product Synonym Names    Goat Anti-SORBS1/ponsin (internal region) Antibody; SORBS1; PONSIN; sorbin and SH3 domain containing 1; CAP; SH3D5; SORB1; SH3P12; ponsin; sh3p12; FLJ12406; KIAA1296; DKFZP586P1422; DKFZp451C066; SH3-domain protein 5 (ponsin); FLAF2; FLJ12406; R85FL; Fas-ligand associated factor 2; c-Cbl associated protei; SORBS1 antibody; PONSIN antibody; sorbin and SH3 domain containing 1 antibody; CAP antibody; SH3D5 antibody; SORB1 antibody; SH3P12 antibody; ponsin antibody; sh3p12 antibody; FLJ12406 antibody; KIAA1296 antibody; DKFZP586P1422 antibody; DKFZp451C066 antibody; SH3-domain protein 5 (ponsin) antibody; FLAF2 antibody; FLJ12406 antibody; R85FL antibody; Fas-ligand associated factor 2 antibody; c-Cbl associated protein antibody; DKFZp586P1422 antibody; OTTHUMP00000020142 antibody; OTTHUMP00000020143 antibody; OTTHUMP00000020144 antibody; OTTHUMP00000020145 antibody; ponsin antibody; Ponsin; SORBS1 / Ponsin (C Terminus)
 Product Gene Name   

anti-SORBS1 antibody

[Similar Products]
 Antibody/Peptide Pairs    SORBS1 / Ponsin peptide (MBS428597) is used for blocking the activity of SORBS1/Ponsin antibody (MBS421322)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    GTFPGNYVKP LYL
 OMIM    605264
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-GTFPGNYVKPLYL, from the C Terminus of the protein sequence according to NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognize all seven reported isoforms (NP_006425.2, NP_056200.1, NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_079267.1 and NP_001030129.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SORBS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SORBS1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-SORBS1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Skeletal Muscle shows spotty staining on muscle fibres in longitudinal section. Recommended concentration, 2.5ug/ml. Data obtained from a previous batch.
Western Blot: No signal obtained yet but low background observed in human heart and 293 lysates at up to 2ug/ml.
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 Immunohistochemistry (IHC) of anti-SORBS1 antibody    (2.5ug/ml) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-SORBS1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SORBS1. It may not necessarily be applicable to this product.
 NCBI GI #    78000160
 NCBI GeneID    10580
 NCBI Accession #    NP_006425.2 [Other Products]
 NCBI Related Accession #    NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006434.2 [Other Products]
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 UniProt Secondary Accession #    O43857; Q5T923; Q5T924; Q5T927; Q5T928; A0AED4; A6NEK3; A6NID8; A6NJS4; A7MD40; D3DR42 [Other Products]
 UniProt Related Accession #    Q9BX66 [Other Products]
 Molecular Weight    143,741 Da
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 NCBI Official Full Name    sorbin and SH3 domain-containing protein 1 isoform 1
 NCBI Official Synonym Full Names    sorbin and SH3 domain containing 1
 NCBI Official Symbol    SORBS1 [Similar Products]
 NCBI Official Synonym Symbols   
CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12
[Similar Products]
 NCBI Protein Information    sorbin and SH3 domain-containing protein 1
 UniProt Protein Name    Sorbin and SH3 domain-containing protein 1
 UniProt Synonym Protein Names   
Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP
 Protein Family    Sorbin and SH3 domain-containing protein
 UniProt Gene Name    SORBS1 [Similar Products]
 UniProt Synonym Gene Names    CAP [Similar Products]
 UniProt Entry Name    SRBS1_HUMAN
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 NCBI Summary for SORBS1    This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
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 UniProt Comments for SORBS1    SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: cell-cell adherens junction; cell-substrate adherens junction; centrosome; cytoplasm; cytosol; focal adhesion; lipid raft; nucleoplasm; nucleus; plasma membrane; stress fiber; zonula adherens

Molecular Function: actin binding; cytoskeletal protein binding; insulin receptor binding; protein binding; SH3/SH2 adaptor activity

Biological Process: cell-matrix adhesion; cellular response to insulin stimulus; focal adhesion formation; glucose transport; insulin receptor signaling pathway; muscle contraction; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of lipid biosynthetic process; stress fiber formation
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 Research Articles on SORBS1    1. data suggest that SORBS1 might be a gene involved in diabetic nephropathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SORBS1 antibodyPathways associated with anti-SORBS1 antibody
 Reference Product  PubMed Publications
 CBL antibody  >9 publications with SORBS1 and CBL
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-SORBS1 antibodyOrgans/Tissues associated with anti-SORBS1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >7 publications with SORBS1 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with SORBS1 and Inflammation
 Heart Diseases Antibodies  >3 publications with SORBS1 and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with SORBS1 and Nervous System Diseases
 Hypertrophy Antibodies  >2 publications with SORBS1 and Hypertrophy
 Cardiomegaly Antibodies  >2 publications with SORBS1 and Cardiomegaly
 Skin Diseases Antibodies  >2 publications with SORBS1 and Skin Diseases
 Hypertension Antibodies  >2 publications with SORBS1 and Hypertension
 Disease Models, Animal Antibodies  >2 publications with SORBS1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with SORBS1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with SORBS1 and Muscle
 Adipose Tissue Antibodies  >9 publications with SORBS1 and Adipose Tissue
 Connective Tissue Antibodies  >6 publications with SORBS1 and Connective Tissue
 Heart Antibodies  >5 publications with SORBS1 and Heart
 Liver Antibodies  >3 publications with SORBS1 and Liver
 Embryonic Tissue Antibodies  >2 publications with SORBS1 and Embryonic Tissue
 Bone Antibodies  >2 publications with SORBS1 and Bone
 Ovary Antibodies  >2 publications with SORBS1 and Ovary
 Prostate Antibodies  >2 publications with SORBS1 and Prostate
 Brain Antibodies  >2 publications with SORBS1 and Brain
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