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anti-SOSS antibody :: Rabbit anti-Human SOSS complex subunit B2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1492553
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOSS complex subunit B2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human SOSS complex subunit B2 polyclonal Antibody

 Product Synonym Names    Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2; NABP1; OBFC2A; SSB2
 Product Gene Name   

anti-SOSS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612103
 3D Structure    ModBase 3D Structure for Q96AH0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human SOSS complex subunit B2 protein(1-204aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-168821
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SOSS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SOSS antibody

   Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
 Applications Tested/Suitable for anti-SOSS antibody   

ELISA (EIA), Western Blot (WB)

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 Western Blot (WB) of anti-SOSS antibody    Western blot
All lanes: SOSS complex subunit B2 antibody at 2ug/ml
Lane 1:Hela whole cell lysate
Lane 2:jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 23,14,15 kDa
Observed band size: 22 kDa

anti-SOSS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SOSS. It may not necessarily be applicable to this product.
 NCBI GI #    72534722
 NCBI GeneID    64859
 NCBI Accession #    NP_001026886.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001031716.2 [Other Products]
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 UniProt Primary Accession #    Q96AH0 [Other Products]
 UniProt Secondary Accession #    Q658Y8; Q9H5X6 [Other Products]
 UniProt Related Accession #    Q96AH0 [Other Products]
 Molecular Weight    14,677 Da
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 NCBI Official Full Name    SOSS complex subunit B2 isoform 1
 NCBI Official Synonym Full Names    nucleic acid binding protein 1
 NCBI Official Symbol    NABP1 [Similar Products]
 NCBI Official Synonym Symbols   
SSB2; OBFC2A; SOSS-B2
[Similar Products]
 NCBI Protein Information    SOSS complex subunit B2
 UniProt Protein Name    SOSS complex subunit B2
 UniProt Synonym Protein Names   
Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
 Protein Family    SOSS complex
 UniProt Gene Name    NABP1 [Similar Products]
 UniProt Synonym Gene Names    OBFC2A; SSB2; SOSS-B2; hSSB2 [Similar Products]
 UniProt Entry Name    SOSB2_HUMAN
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 NCBI Summary for SOSS    Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
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 UniProt Comments for SOSS    OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: protein binding; RNA binding; single-stranded DNA binding

Biological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation
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 Research Articles on SOSS    1. hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOSS antibodyOrgans/Tissues associated with anti-SOSS antibody
 Reference Product  PubMed Publications
 NABP2 antibody  >3 publications with SOSS and NABP2
 INTS3 antibody  >1 publications with SOSS and INTS3
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >2 publications with SOSS and Thymus
 Thyroid Antibodies  >1 publications with SOSS and Thyroid
 Spleen Antibodies  >1 publications with SOSS and Spleen
 Testis Antibodies  >1 publications with SOSS and Testis
 Embryonic Tissue Antibodies  >1 publications with SOSS and Embryonic Tissue
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