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anti-SOX2 antibody :: Rabbit anti-Human SOX2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241751
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human SOX2

 Product Synonym Names    Anti-SOX2 Antibody (N-Terminus) IHC-plus; SOX2; MCOPS3; Transcription factor SOX2; ANOP3; Transcription factor SOX-2; SRY-related HMG-box gene 2; Human SOX2
 Product Gene Name   

anti-SOX2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 206900
 3D Structure    ModBase 3D Structure for P48431
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Peptide-KLH (N-terminal)
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
 Concentration    0.25 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human SOX2.
 Immunogen Type    Synthetic peptide
 Immunogen    SOX2 antibody was raised against synthetic peptide from human SOX2.
 Antigen Modification    N-Terminus
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-SOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SOX2 antibody

   SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.
 Product Categories/Family for anti-SOX2 antibody    Family: Transcription factor
 Applications Tested/Suitable for anti-SOX2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-SOX2 antibody    IHC-P (1:50), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-SOX2 antibody    Anti-SOX2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-SOX2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SOX2 antibody    NTERA-2 whole cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal antibody raised against the N-terminal region of SOX2. Proteins were visualized using HRP Donkey anti-rabbit IgG and a chemiluminescence detection system.
anti-SOX2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SOX2. It may not necessarily be applicable to this product.
 NCBI GI #    28195386
 NCBI GeneID    6657
 NCBI Accession #    NP_003097.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003106.3 [Other Products]
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 UniProt Primary Accession #    P48431 [Other Products]
 UniProt Secondary Accession #    Q14537 [Other Products]
 UniProt Related Accession #    P48431 [Other Products]
 Molecular Weight    34,310 Da
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 NCBI Official Full Name    transcription factor SOX-2
 NCBI Official Synonym Full Names    SRY (sex determining region Y)-box 2
 NCBI Official Symbol    SOX2 [Similar Products]
 NCBI Official Synonym Symbols   
ANOP3; MCOPS3
[Similar Products]
 NCBI Protein Information    transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2
 UniProt Protein Name    Transcription factor SOX-2
 UniProt Gene Name    SOX2 [Similar Products]
 UniProt Entry Name    SOX2_HUMAN
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 NCBI Summary for SOX2    This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOX2    SOX2: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.

Protein type: Cell development/differentiation; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 3q26.3-q27

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; tongue development; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; diencephalon morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; olfactory placode formation; forebrain neuron differentiation; detection of mechanical stimulus involved in equilibrioception; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; tissue regeneration; forebrain development; male genitalia development; positive regulation of cell-cell adhesion; response to wounding; adenohypophysis development; positive regulation of epithelial cell differentiation; negative regulation of osteoblast differentiation; cell cycle arrest; inner ear development; positive regulation of Notch signaling pathway; negative regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; inner ear morphogenesis; response to retinoic acid; neuron fate commitment; detection of mechanical stimulus involved in sensory perception of sound; osteoblast differentiation; negative regulation of neuron differentiation; eye development; regulation of gene expression; pituitary gland development; glial cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; pigment biosynthetic process; positive regulation of neuron differentiation; alveolus development; retina morphogenesis in camera-type eye

Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia
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 Research Articles on SOX2    1. This study is the first to establish a functional link between endogenous Sox2 expression and cancer stem cells in cervical carcinomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOX2 antibodyPathways associated with anti-SOX2 antibody
 Reference Product  PubMed Publications
 NANOG antibody  >1324 publications with SOX2 and NANOG
 POU5F1 antibody  >1004 publications with SOX2 and POU5F1
 PAX6 antibody  >183 publications with SOX2 and PAX6
 FGF4 antibody  >69 publications with SOX2 and FGF4
 ATOH1 antibody  >27 publications with SOX2 and ATOH1
 FGF10 antibody  >11 publications with SOX2 and FGF10
 EYA1 antibody  >9 publications with SOX2 and EYA1
 POU2F1 antibody  >6 publications with SOX2 and POU2F1
 SPP1 antibody  >4 publications with SOX2 and SPP1
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway antibodies  POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway Diagram
 POU5F1 (OCT4), SOX2, NANOG Repress Genes Related To Differentiation Pathway antibodies  POU5F1 (OCT4), SOX2, NANOG Repress Genes Related To Differentiation Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram
Diseases associated with anti-SOX2 antibodyOrgans/Tissues associated with anti-SOX2 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >114 publications with SOX2 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >114 publications with SOX2 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >106 publications with SOX2 and Lung Diseases
 Lung Neoplasms Antibodies  >100 publications with SOX2 and Lung Neoplasms
 Skin Diseases Antibodies  >92 publications with SOX2 and Skin Diseases
 Cell Transformation, Neoplastic Antibodies  >89 publications with SOX2 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >68 publications with SOX2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >64 publications with SOX2 and Breast Neoplasms
 Small Cell Lung Carcinoma Antibodies  >63 publications with SOX2 and Small Cell Lung Carcinoma
 Neoplasms, Experimental Antibodies  >53 publications with SOX2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >705 publications with SOX2 and Embryonic Tissue
 Brain Antibodies  >654 publications with SOX2 and Brain
 Eye Antibodies  >250 publications with SOX2 and Eye
 Lung Antibodies  >200 publications with SOX2 and Lung
 Muscle Antibodies  >174 publications with SOX2 and Muscle
 Ear Antibodies  >102 publications with SOX2 and Ear
 Testis Antibodies  >98 publications with SOX2 and Testis
 Mouth Antibodies  >65 publications with SOX2 and Mouth
 Pituitary Gland Antibodies  >58 publications with SOX2 and Pituitary Gland
 Placenta Antibodies  >50 publications with SOX2 and Placenta
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