NP_003097.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,310 Da
NCBI Official Full Name
transcription factor SOX-2
NCBI Official Synonym Full Names
SRY-box 2
NCBI Protein Information
transcription factor SOX-2
UniProt Protein Name
Transcription factor SOX-2
NCBI Summary for SOX2
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
UniProt Comments for SOX2
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation ().
Research Articles on SOX2
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Products associated with anti-SOX2 antibody
Pathways associated with anti-SOX2 antibody
Diseases associated with anti-SOX2 antibody
Organs/Tissues associated with anti-SOX2 antibody
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