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anti-SP140 antibody :: Rabbit SP140 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS835436
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SP140, Polyclonal Antibody

★Popular Item★
 Also Known As   

SP140 antibody

 Product Synonym Names    Polyclonal SP140; Anti-SP140; SP 140; SP-140; SP140 nuclear body protein; SP140
 Product Gene Name   

anti-SP140 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608602
 3D Structure    ModBase 3D Structure for Q13342
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    Lyophilized powder. Add 100 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
 Concentration    1 mg/ml (lot specific)
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 Biological Significance    SP140 is the nuclear body protein found specifically in all NP cells. HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif.
 Immunogen    SP140 antibody was raised in rabbit using the N terminal of SP140 as the immunogen
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 Preparation and Storage    Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-SP140 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SP140 antibody

   Rabbit polyclonal SP140 antibody
 Product Categories/Family for anti-SP140 antibody    Signal Transduction
 Applications Tested/Suitable for anti-SP140 antibody   

Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-SP140 antibody    Optimal conditions to be determined by the end user
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 Western Blot (WB) of anti-SP140 antibody    Western Blot showing SP140 antibody used at a concentration of 5.0 ug/ml against Raji Cell Lysate
anti-SP140 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SP140 antibody    SP140 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X
anti-SP140 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SP140. It may not necessarily be applicable to this product.
 NCBI GI #    52487277
 NCBI GeneID    11262
 NCBI Accession #    NP_001005176 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005176.2 [Other Products]
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 UniProt Primary Accession #    Q13342 [Other Products]
 UniProt Secondary Accession #    Q0VGE5; Q13341; Q3KR17; Q4ZG66; Q53TG1; Q6NSG4; Q92881; Q96TG3; E7ESH9; E7EUR5; E9PFJ6 [Other Products]
 UniProt Related Accession #    Q13342 [Other Products]
 Molecular Weight    91,673 Da
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 NCBI Official Full Name    nuclear body protein SP140 isoform 2
 NCBI Official Synonym Full Names    SP140 nuclear body protein
 NCBI Official Symbol    SP140 [Similar Products]
 NCBI Official Synonym Symbols   
LYSP100; LYSP100-A; LYSP100-B
[Similar Products]
 NCBI Protein Information    nuclear body protein SP140
 UniProt Protein Name    Nuclear body protein SP140
 UniProt Synonym Protein Names   
Lymphoid-restricted homolog of Sp100
 Protein Family    Nuclear body protein
 UniProt Gene Name    SP140 [Similar Products]
 UniProt Synonym Gene Names    LYSp100 [Similar Products]
 UniProt Entry Name    SP140_HUMAN
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 UniProt Comments for SP140    SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity

Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response
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 Research Articles on SP140    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SP140 antibodyDiseases associated with anti-SP140 antibody
 Reference Product  PubMed Publications
 PML antibody  >8 publications with SP140 and PML
 DAXX antibody  >1 publications with SP140 and DAXX
 PIN1 antibody  >1 publications with SP140 and PIN1
 ARID3A antibody  >1 publications with SP140 and ARID3A
 Disease Name  Pubmed Publications
 Immunoproliferative Disorders Antibodies  >5 publications with SP140 and Immunoproliferative Disorders
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >4 publications with SP140 and Leukemia, Lymphocytic, Chronic, B-Cell
 Breast Neoplasms Antibodies  >1 publications with SP140 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with SP140 and Prostatic Neoplasms
 Respiratory Tract Diseases Antibodies  >1 publications with SP140 and Respiratory Tract Diseases
 Inflammation Antibodies  >1 publications with SP140 and Inflammation
Organs/Tissues associated with anti-SP140 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with SP140 and Blood
 Liver Antibodies  >2 publications with SP140 and Liver
 Spleen Antibodies  >2 publications with SP140 and Spleen
 Lymph Antibodies  >1 publications with SP140 and Lymph
 Skin Antibodies  >1 publications with SP140 and Skin
 Vascular Antibodies  >1 publications with SP140 and Vascular
 Mammary Gland Antibodies  >1 publications with SP140 and Mammary Gland
 Lymph Node Antibodies  >1 publications with SP140 and Lymph Node
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