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anti-SPARC antibody :: Rabbit SPARC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126694
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SPARC, Polyclonal Antibody

★Popular Item★
 Also Known As   

SPARC Polyclonal Antibody

 Product Synonym Names    ON
 Product Gene Name   

anti-SPARC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182120
 3D Structure    ModBase 3D Structure for P09486
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human SPARC
 Calculated Molecular Weight    35kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-SPARC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SPARC antibody

   SPARC (secreted protein acidic and rich in cysteine), also known as osteonectin and BM40, is a secreted matricellular glycoprotein that belongs to a group of functionally related glycoproteins that includes tenascins C and X, thrombospondins 1 and 2, and osteopontin (1). Members in this class of glycoproteins are involved in tissue renewal, tissue remodeling, and embryonic development and work by exerting counter-adhesive and antiproliferative effects that lead to changes in cell shape, disruption of cell adhesion, and inhibition of the cell cycle (2). SPARC is expressed at high levels in bone tissue but is widely distributed in many other tissues and cell types (3), and is known to be associated with tissues undergoing morphogenesis, angiogenesis, mineralization, and other pathological responses to injury and tumorigenesis (4,5). SPARC has also been linked with obesity and diabetes (6).
 Product Categories/Family for anti-SPARC antibody    Polyclonal
 Applications Tested/Suitable for anti-SPARC antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SPARC antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-SPARC antibody    Western blot analysis of extracts of various cell lines, using SPARC antibody.
anti-SPARC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-SPARC antibody    Immunohistochemistry of paraffin-embedded rat kidney using SPARC antibody at dilution of 1:100 (200x lens).
anti-SPARC antibody Immunohistochemistry (IHC (IHC) image
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NCBI/Uniprot data below describe general gene information for SPARC. It may not necessarily be applicable to this product.
 NCBI GI #    129283
 NCBI GeneID    6678
 NCBI Accession #    P09486.1 [Other Products]
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 UniProt Primary Accession #    P09486 [Other Products]
 UniProt Secondary Accession #    Q6IBK4; D3DQH9 [Other Products]
 UniProt Related Accession #    P09486 [Other Products]
 Molecular Weight    303
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 NCBI Official Full Name    SPARC
 NCBI Official Synonym Full Names    secreted protein, acidic, cysteine-rich (osteonectin)
 NCBI Official Symbol    SPARC [Similar Products]
 NCBI Official Synonym Symbols   
ON
[Similar Products]
 NCBI Protein Information    SPARC; BM-40; osteonectin; cysteine-rich protein; basement-membrane protein 40; secreted protein acidic and rich in cysteine
 UniProt Protein Name    SPARC
 UniProt Synonym Protein Names   
Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine
 Protein Family    SPARC
 UniProt Gene Name    SPARC [Similar Products]
 UniProt Synonym Gene Names    ON; BM-40; ON [Similar Products]
 UniProt Entry Name    SPRC_HUMAN
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 NCBI Summary for SPARC    This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]
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 UniProt Comments for SPARC    SPARC: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.3-q32

Cellular Component: extracellular space; platelet alpha granule membrane; nuclear matrix; cell surface; mitochondrion; cytoplasm; extracellular region; plasma membrane; basement membrane

Molecular Function: collagen binding; protein binding; extracellular matrix binding; calcium ion binding

Biological Process: response to peptide hormone stimulus; receptor-mediated endocytosis; platelet activation; response to gravity; extracellular matrix organization and biogenesis; ossification; response to cAMP; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; signal transduction; response to L-ascorbic acid; negative regulation of angiogenesis; response to cadmium ion; response to ethanol; platelet degranulation; response to cytokine stimulus; response to lead ion; negative regulation of endothelial cell proliferation; regulation of cell morphogenesis; blood coagulation; response to calcium ion; inner ear development; lung development

Disease: Osteogenesis Imperfecta, Type Xvii
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 Research Articles on SPARC    1. These results indicate that promoter methylation status of PCDH10, SPARC, and UCHL1 may be used both as prognostic and predictive molecular marker for colorectal cancer patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SPARC antibodyPathways associated with anti-SPARC antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >71 publications with SPARC and TGFB1
 COL1A2 antibody  >33 publications with SPARC and COL1A2
 COL1A1 antibody  >30 publications with SPARC and COL1A1
 EGF antibody  >26 publications with SPARC and EGF
 SERPINE1 antibody  >18 publications with SPARC and SERPINE1
 FN1 antibody  >15 publications with SPARC and FN1
 TIMP1 antibody  >7 publications with SPARC and TIMP1
 PLG antibody  >2 publications with SPARC and PLG
 ALB antibody  >1 publications with SPARC and ALB
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Scavenging By Class H Receptors Pathway antibodies  Scavenging By Class H Receptors Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-SPARC antibodyOrgans/Tissues associated with anti-SPARC antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >111 publications with SPARC and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >109 publications with SPARC and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >103 publications with SPARC and Disease Models, Animal
 Inflammation Antibodies  >102 publications with SPARC and Inflammation
 Fibrosis Antibodies  >94 publications with SPARC and Fibrosis
 Brain Diseases Antibodies  >76 publications with SPARC and Brain Diseases
 Breast Neoplasms Antibodies  >72 publications with SPARC and Breast Neoplasms
 Necrosis Antibodies  >61 publications with SPARC and Necrosis
 Pancreatic Neoplasms Antibodies  >57 publications with SPARC and Pancreatic Neoplasms
 Neoplasms, Experimental Antibodies  >52 publications with SPARC and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1076 publications with SPARC and Bone
 Connective Tissue Antibodies  >445 publications with SPARC and Connective Tissue
 Blood Antibodies  >332 publications with SPARC and Blood
 Vascular Antibodies  >300 publications with SPARC and Vascular
 Bone Marrow Antibodies  >202 publications with SPARC and Bone Marrow
 Muscle Antibodies  >180 publications with SPARC and Muscle
 Embryonic Tissue Antibodies  >173 publications with SPARC and Embryonic Tissue
 Mouth Antibodies  >159 publications with SPARC and Mouth
 Brain Antibodies  >153 publications with SPARC and Brain
 Eye Antibodies  >121 publications with SPARC and Eye
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