Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow SPDEF rightarrow Polyclonal SPDEF  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • NDFIP1 Antibody
 • DCuN1D1 Recombinant Protein
 • integrin, beta 1 Antibody
 • IGF1R3 ELISA Kit
 • Prostate Specific Antigen (PSA) >98% Pure (KLK3) Native Protein
 • Tartrate resistant acid phosphatase 5b (TRACP-5b) ELISA Kit
 • Horse IgA ELISA Kit
 • cystathionine beta synthase (CBS) ELISA Kit
 • Horse IgG (Fab'2) (HRP) Immunoglobulin
 • FAM53B Antibody
 • UCP1 Antibody
 • SOMATOSTATIN (SST) Antibody
 • CD248 Blocking Peptide
 • Albumin Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-SPDEF antibody :: Rabbit anti-Human, Mouse SPDEF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7049204
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SPDEF, Polyclonal Antibody

★Popular Item★
 Also Known As   

SPDEF Antibody

 Product Synonym Names    SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor; SPDEF; PDEF; PSE
 Product Gene Name   

anti-SPDEF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    AB031549 mRNA
 3D Structure    ModBase 3D Structure for O95238
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
Section Bar
 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
Section Bar
 Immunogen    Recombinant human SAM pointed domain-containing Ets transcription factor protein (145-247AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46446 / sc-46445 / sc-46443 / sc-67022
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SPDEF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-SPDEF antibody

   May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
 Applications Tested/Suitable for anti-SPDEF antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SPDEF antibody    WB: 1: 1000-1: 5000
IHC: 1: 20-1: 200
Section Bar
 Western Blot (WB) of anti-SPDEF antibody    Western Blot
Positive WB detected in:Mouse brain tissue
All lanes: SPDEF antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38,36 kDa
Observed band size: 38 kDa

anti-SPDEF antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-SPDEF antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7049204 at dilution of 1:100
anti-SPDEF antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-SPDEF antibody    Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7049204 at dilution of 1:100
anti-SPDEF antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SPDEF. It may not necessarily be applicable to this product.
 NCBI GI #    356582513
 NCBI GeneID    25803
 NCBI Accession #    NP_001239223.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001252294.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O95238 [Other Products]
 UniProt Secondary Accession #    B4DWH8; F5H778 [Other Products]
 UniProt Related Accession #    O95238 [Other Products]
 Molecular Weight    35,715 Da
Table BarTOPTable Bar
 NCBI Official Full Name    SAM pointed domain-containing Ets transcription factor isoform 2
 NCBI Official Synonym Full Names    SAM pointed domain containing ETS transcription factor
 NCBI Official Symbol    SPDEF [Similar Products]
 NCBI Official Synonym Symbols   
PDEF; bA375E1.3
[Similar Products]
 NCBI Protein Information    SAM pointed domain-containing Ets transcription factor
 UniProt Protein Name    SAM pointed domain-containing Ets transcription factor
 UniProt Synonym Protein Names   
Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor
 Protein Family    SAM pointed domain-containing Ets transcription factor
 UniProt Gene Name    SPDEF [Similar Products]
 UniProt Synonym Gene Names    PDEF; PSE; Prostate-specific Ets [Similar Products]
 UniProt Entry Name    SPDEF_HUMAN
Section Bar
 NCBI Summary for SPDEF    The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Section Bar
 UniProt Comments for SPDEF    SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleus

Biological Process: cell differentiation; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis
Table BarTOPTable Bar
 Research Articles on SPDEF    1. PDEF gene expression is associated with the extent of bladder neoplasia and PDEF modulated the expressions of EMT-related genes.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-SPDEF antibodyPathways associated with anti-SPDEF antibody
 Reference Product  PubMed Publications
 STAT6 antibody  >6 publications with SPDEF and STAT6
 NKX2-1 antibody  >4 publications with SPDEF and NKX2-1
 BIRC5 antibody  >3 publications with SPDEF and BIRC5
 NKX3-1 antibody  >3 publications with SPDEF and NKX3-1
 GATA6 antibody  >2 publications with SPDEF and GATA6
 SNAI2 antibody  >1 publications with SPDEF and SNAI2
 NOTCH1 antibody  >1 publications with SPDEF and NOTCH1
 Products by Pathway  Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
Diseases associated with anti-SPDEF antibodyOrgans/Tissues associated with anti-SPDEF antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >38 publications with SPDEF and Breast Neoplasms
 Lung Diseases Antibodies  >25 publications with SPDEF and Lung Diseases
 Prostatic Diseases Antibodies  >24 publications with SPDEF and Prostatic Diseases
 Inflammation Antibodies  >17 publications with SPDEF and Inflammation
 Metaplasia Antibodies  >16 publications with SPDEF and Metaplasia
 Hyperplasia Antibodies  >12 publications with SPDEF and Hyperplasia
 Adenocarcinoma Antibodies  >11 publications with SPDEF and Adenocarcinoma
 Disease Models, Animal Antibodies  >7 publications with SPDEF and Disease Models, Animal
 Fibrosis Antibodies  >5 publications with SPDEF and Fibrosis
 Ovarian Neoplasms Antibodies  >5 publications with SPDEF and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >59 publications with SPDEF and Prostate
 Intestine Antibodies  >32 publications with SPDEF and Intestine
 Lung Antibodies  >29 publications with SPDEF and Lung
 Brain Antibodies  >3 publications with SPDEF and Brain
 Ovary Antibodies  >3 publications with SPDEF and Ovary
 Nerve Antibodies  >1 publications with SPDEF and Nerve
 Mammary Gland Antibodies  >1 publications with SPDEF and Mammary Gland
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions