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anti-SRCAP antibody :: Goat SRCAP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421768 anti-SRCAP antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SRCAP, Polyclonal Antibody

 Also Known As   

Goat anti-SRCAP Antibody

 Product Synonym Names    Goat Anti-SRCAP (aa309-322) Antibody; SRCAP; Snf2-related CREBBP activator protein; DOMO1; EAF1; FLJ44499; KIAA0309; SWR1; OTTHUMP00000163226; Snf2-related CBP activator protein; Swi2/Snf2-related ATPase homolog, domino homolog 1; SRCAP antibody; Snf2-related CREBBP activator protein antibody; DOMO1 antibody; EAF1 antibody; FLJ44499 antibody; KIAA0309 antibody; SWR1 antibody; OTTHUMP00000163226 antibody; Snf2-related CBP activator protein antibody; Swi2/Snf2-related ATPase homolog; domino homolog 1 antibody
 Product Gene Name   

anti-SRCAP antibody

[Similar Products]
 Antibody/Peptide Pairs    SRCAP peptide (MBS425088) is used for blocking the activity of SRCAP antibody (MBS421768)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DEAQNIKNFK SQR
 OMIM    136140
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DEAQNIKNFKSQR, from the internal region of the protein sequence according to NP_006653.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SRCAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SRCAP antibody   

Peptide ELISA (EIA)

 Application Notes for anti-SRCAP antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments in lysates of cell lines K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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NCBI/Uniprot data below describe general gene information for SRCAP. It may not necessarily be applicable to this product.
 NCBI GI #    146219843
 NCBI GeneID    10847
 NCBI Accession #    NP_006653.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006662.2 [Other Products]
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 UniProt Secondary Accession #    O15026; Q7Z744; Q9Y5L9; B0JZA6 [Other Products]
 UniProt Related Accession #    Q6ZRS2 [Other Products]
 Molecular Weight    327,838 Da
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 NCBI Official Full Name    helicase SRCAP
 NCBI Official Synonym Full Names    Snf2-related CREBBP activator protein
 NCBI Official Symbol    SRCAP [Similar Products]
 NCBI Official Synonym Symbols   
EAF1; FLHS; SWR1; DOMO1
[Similar Products]
 NCBI Protein Information    helicase SRCAP
 UniProt Protein Name    Helicase SRCAP
 UniProt Synonym Protein Names   
Domino homolog 2; Snf2-related CBP activator
 Protein Family    Helicase
 UniProt Gene Name    SRCAP [Similar Products]
 UniProt Synonym Gene Names    KIAA0309 [Similar Products]
 UniProt Entry Name    SRCAP_HUMAN
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 NCBI Summary for SRCAP    This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
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 UniProt Comments for SRCAP    SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.-; Transcription, coactivator/corepressor; Helicase; EC 3.6.1.-; DNA-binding; Acetyltransferase

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: Golgi apparatus; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: ATP binding; DNA binding; helicase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity

Biological Process: histone acetylation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction

Disease: Floating-harbor Syndrome
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 Research Articles on SRCAP    1. Data confirm a mutational hot spot in the final exon of SRCAP in the majority of Floating-Harbor syndrome patients but also show that exon 33 of this gene can be affected.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-SRCAP antibodyOrgans/Tissues associated with anti-SRCAP antibody
 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >9 publications with SRCAP and Heart Defects, Congenital
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies  >9 publications with SRCAP and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Abnormalities, Multiple Antibodies  >9 publications with SRCAP and Abnormalities, Multiple
 Liver Diseases Antibodies  >8 publications with SRCAP and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with SRCAP and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >8 publications with SRCAP and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with SRCAP and Neoplasms, Experimental
 Liver Neoplasms, Experimental Antibodies  >3 publications with SRCAP and Liver Neoplasms, Experimental
 Chromosome Aberrations Antibodies  >2 publications with SRCAP and Chromosome Aberrations
 Prostatic Diseases Antibodies  >2 publications with SRCAP and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with SRCAP and Blood
 Bone Antibodies  >5 publications with SRCAP and Bone
 Prostate Antibodies  >2 publications with SRCAP and Prostate
 Lymph Node Antibodies  >1 publications with SRCAP and Lymph Node
 Kidney Antibodies  >1 publications with SRCAP and Kidney
 Muscle Antibodies  >1 publications with SRCAP and Muscle
 Lymph Antibodies  >1 publications with SRCAP and Lymph
 Thyroid Antibodies  >1 publications with SRCAP and Thyroid
 Lung Antibodies  >1 publications with SRCAP and Lung
 Brain Antibodies  >1 publications with SRCAP and Brain
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