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anti-SRD5A1 antibody :: Goat SRD5A1/5-alpha reductase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420692
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SRD5A1/5-alpha reductase 1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-SRD5A1/5-alpha reductase 1 Antibody

 Product Synonym Names    Goat Anti-SRD5A1 Antibody; SRD5A1; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); 5-alpha reductase; steroid 5-alpha-reductase type I; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1; steroid-5-alpha-reductase 1; SRD5A1 antibody; steroid-5-alpha-reductase; alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) antibody; 5-alpha reductase antibody; steroid 5-alpha-reductase type I antibody; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1 antibody; steroid-5-alpha-reductase 1 antibody; 5-alpha reductase 1; SRD5A1 / 5-alpha reductase 1
 Product Gene Name   

anti-SRD5A1 antibody

[Similar Products]
 Antibody/Peptide Pairs    SRD5A1 / 5-alpha reductase 1 peptide (MBS428042) is used for blocking the activity of SRD5A1/5-alpha reductase 1 antibody (MBS420692)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ATATGVAEER LLC
 OMIM    184753
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence ATATGVAEERLLC, from the N Terminus of the protein sequence according to NP_001038.1.
 Epitope    N Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SRD5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SRD5A1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-SRD5A1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Prostate shows reticulate staining in the cytoplasm of secretory cells in the gland. Recommended concentration, 4-6ug/ml.
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 Immunohistochemistry (IHC) of anti-SRD5A1 antibody    (4ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
anti-SRD5A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SRD5A1. It may not necessarily be applicable to this product.
 NCBI GI #    4507201
 NCBI GeneID    6715
 NCBI Accession #    NP_001038.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001047.3 [Other Products]
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 UniProt Secondary Accession #    Q9UHY4; Q9UP36; Q9UP37; B2R7Q1 [Other Products]
 UniProt Related Accession #    P18405 [Other Products]
 Molecular Weight    29,459 Da
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 NCBI Official Full Name    3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform 1
 NCBI Official Synonym Full Names    steroid 5 alpha-reductase 1
 NCBI Official Symbol    SRD5A1 [Similar Products]
 NCBI Official Synonym Symbols   
S5AR 1
[Similar Products]
 NCBI Protein Information    3-oxo-5-alpha-steroid 4-dehydrogenase 1
 UniProt Protein Name    3-oxo-5-alpha-steroid 4-dehydrogenase 1
 UniProt Synonym Protein Names   
SR type 1; Steroid 5-alpha-reductase 1; S5AR 1
 Protein Family    3-oxo-5-alpha-steroid 4-dehydrogenase
 UniProt Gene Name    SRD5A1 [Similar Products]
 UniProt Synonym Gene Names    S5AR 1 [Similar Products]
 UniProt Entry Name    S5A1_HUMAN
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 NCBI Summary for SRD5A1    Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
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 UniProt Comments for SRD5A1    SRD5A1: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Belongs to the steroid 5-alpha reductase family.

Protein type: Membrane protein, integral; EC 1.3.1.22; Membrane protein, multi-pass; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: cell soma; endoplasmic reticulum membrane; integral to membrane; myelin sheath; perinuclear region of cytoplasm

Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; cholestenone 5-alpha-reductase activity; electron carrier activity

Biological Process: androgen biosynthetic process; cell differentiation; cellular response to insulin stimulus; cellular response to starvation; cerebral cortex development; circadian sleep/wake cycle, REM sleep; diterpenoid metabolic process; female genitalia development; hippocampus development; hypothalamus development; liver development; male genitalia development; male gonad development; pituitary gland development; progesterone metabolic process; response to drug; response to follicle-stimulating hormone stimulus; response to muscle activity; serotonin metabolic process; sex determination; spinal cord development; thalamus development; urogenital system development
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 Research Articles on SRD5A1    1. the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 and SRD5A2 in a set of Spanish prostate cancer patients, were evaluated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SRD5A1 antibodyPathways associated with anti-SRD5A1 antibody
 Reference Product  PubMed Publications
 CYP17A1 antibody  >27 publications with SRD5A1 and CYP17A1
 HSD3B1 antibody  >25 publications with SRD5A1 and HSD3B1
 CYP19A1 antibody  >21 publications with SRD5A1 and CYP19A1
 HSD17B3 antibody  >14 publications with SRD5A1 and HSD17B3
 HSD17B2 antibody  >13 publications with SRD5A1 and HSD17B2
 HSD3B2 antibody  >11 publications with SRD5A1 and HSD3B2
 SRD5A3 antibody  >11 publications with SRD5A1 and SRD5A3
 HSD17B6 antibody  >4 publications with SRD5A1 and HSD17B6
 AKR1D1 antibody  >3 publications with SRD5A1 and AKR1D1
 UGT2B17 antibody  >2 publications with SRD5A1 and UGT2B17
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones Pathway antibodies  Metabolism Of Steroid Hormones Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Allopregnanolone Biosynthesis Pathway antibodies  Allopregnanolone Biosynthesis Pathway Diagram
 Allopregnanolone Biosynthesis Pathway antibodies  Allopregnanolone Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
Diseases associated with anti-SRD5A1 antibodyOrgans/Tissues associated with anti-SRD5A1 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >35 publications with SRD5A1 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >8 publications with SRD5A1 and Adenocarcinoma
 Carcinoma Antibodies  >8 publications with SRD5A1 and Carcinoma
 Breast Neoplasms Antibodies  >8 publications with SRD5A1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with SRD5A1 and Cardiovascular Diseases
 Polycystic Ovary Syndrome Antibodies  >7 publications with SRD5A1 and Polycystic Ovary Syndrome
 Hyperplasia Antibodies  >6 publications with SRD5A1 and Hyperplasia
 Neoplasm Metastasis Antibodies  >6 publications with SRD5A1 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >6 publications with SRD5A1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >6 publications with SRD5A1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >51 publications with SRD5A1 and Prostate
 Blood Antibodies  >34 publications with SRD5A1 and Blood
 Ovary Antibodies  >17 publications with SRD5A1 and Ovary
 Testis Antibodies  >13 publications with SRD5A1 and Testis
 Brain Antibodies  >13 publications with SRD5A1 and Brain
 Liver Antibodies  >12 publications with SRD5A1 and Liver
 Muscle Antibodies  >11 publications with SRD5A1 and Muscle
 Uterus Antibodies  >7 publications with SRD5A1 and Uterus
 Bone Antibodies  >7 publications with SRD5A1 and Bone
 Embryonic Tissue Antibodies  >6 publications with SRD5A1 and Embryonic Tissue
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