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anti-SRD5A1 antibody :: Rabbit anti-Human SRD5A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9231003
Western Blot (WB)
Unit / Price
0.05 mL  /  $150 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SRD5A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SRD5A1 Antibody (Center)

 Product Synonym Names    3-oxo-5-alpha-steroid 4-dehydrogenase 1; 1.3.1.22; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1; SRD5A1
 Product Gene Name   

anti-SRD5A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M32313 mRNA
 3D Structure    ModBase 3D Structure for P18405
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 Clonality    Polyclonal
 Isotype    Ig
 Clone Number    RB55221
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This SRD5A1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 153-184 amino acids from the Central region of human SRD5A1.
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Antigen Type    Synthesized Peptide
 Antigen Source    Human
 Cellular Location    Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
 Tissue Location    Liver and prostate (at a low level).
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-SRD5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SRD5A1 antibody

   Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
 Product Categories/Family for anti-SRD5A1 antibody    New Antibodies; Primary Antibodies; Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-SRD5A1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SRD5A1 antibody    WB: 1:8000
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 Western Blot (WB) of anti-SRD5A1 antibody    All lanes : Anti-SRD5A1 Antibody (Center) at 1:8000 dilution
Lane 1: human liver lysate
Lane 2: human testis lysate

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 29 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-SRD5A1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SRD5A1. It may not necessarily be applicable to this product.
 NCBI GI #    4507201
 NCBI GeneID    6715
 NCBI Accession #    NP_001038.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001047.3 [Other Products]
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 UniProt Primary Accession #    P18405 [Other Products]
 UniProt Secondary Accession #    Q9UHY4; Q9UP36; Q9UP37; B2R7Q1 [Other Products]
 UniProt Related Accession #    P18405 [Other Products]
 Molecular Weight    29459 Da
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 NCBI Official Full Name    3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform 1
 NCBI Official Synonym Full Names    steroid 5 alpha-reductase 1
 NCBI Official Symbol    SRD5A1 [Similar Products]
 NCBI Official Synonym Symbols   
S5AR 1
[Similar Products]
 NCBI Protein Information    3-oxo-5-alpha-steroid 4-dehydrogenase 1
 UniProt Protein Name    3-oxo-5-alpha-steroid 4-dehydrogenase 1
 UniProt Synonym Protein Names   
SR type 1; Steroid 5-alpha-reductase 1; S5AR 1
 Protein Family    3-oxo-5-alpha-steroid 4-dehydrogenase
 UniProt Gene Name    SRD5A1 [Similar Products]
 UniProt Synonym Gene Names    S5AR 1 [Similar Products]
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 NCBI Summary for SRD5A1    Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
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 UniProt Comments for SRD5A1    SRD5A1: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Belongs to the steroid 5-alpha reductase family.

Protein type: EC 1.3.1.22; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase

Chromosomal Location of Human Ortholog: 5p15.31

Cellular Component: endoplasmic reticulum membrane

Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; electron carrier activity

Biological Process: androgen biosynthetic process; female genitalia development; male genitalia development; progesterone metabolic process; steroid biosynthetic process
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Product References and Citations for anti-SRD5A1 antibody

   Andersson S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644 (1990). Jenkins E.P.,et al.Genomics 11:1102-1112 (1991). Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases. Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548 (2000). Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on SRD5A1    1. SRD5A1 small-interfering RNA knockdown led to significant increase in progesterone receptor-B nuclear import, ectopic, whereas SRD5A1 overexpression resulted in remarkable inhibition of nuclear progesterone receptor-B in P4-treated cells. Repression of SRD5A1 activated progesterone receptor-B responsive gene, whereas overexpression of SRD5A1 possessed an inhibitory effect.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SRD5A1 antibodyPathways associated with anti-SRD5A1 antibody
 Reference Product  PubMed Publications
 AKR1C3 antibody  >25 publications with SRD5A1 and AKR1C3
 HSD3B1 antibody  >16 publications with SRD5A1 and HSD3B1
 CYP19A1 antibody  >13 publications with SRD5A1 and CYP19A1
 HSD17B2 antibody  >10 publications with SRD5A1 and HSD17B2
 HSD3B2 antibody  >10 publications with SRD5A1 and HSD3B2
 HSD17B3 antibody  >9 publications with SRD5A1 and HSD17B3
 AKR1C4 antibody  >4 publications with SRD5A1 and AKR1C4
 HSD17B6 antibody  >4 publications with SRD5A1 and HSD17B6
 UGT2B15 antibody  >3 publications with SRD5A1 and UGT2B15
 AKR1D1 antibody  >3 publications with SRD5A1 and AKR1D1
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Allopregnanolone Biosynthesis Pathway antibodies  Allopregnanolone Biosynthesis Pathway Diagram
 Allopregnanolone Biosynthesis Pathway antibodies  Allopregnanolone Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
Diseases associated with anti-SRD5A1 antibodyOrgans/Tissues associated with anti-SRD5A1 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >27 publications with SRD5A1 and Prostatic Neoplasms
 Urogenital Abnormalities Antibodies  >7 publications with SRD5A1 and Urogenital Abnormalities
 Breast Neoplasms Antibodies  >6 publications with SRD5A1 and Breast Neoplasms
 Hyperplasia Antibodies  >6 publications with SRD5A1 and Hyperplasia
 Polycystic Ovary Syndrome Antibodies  >6 publications with SRD5A1 and Polycystic Ovary Syndrome
 Cardiovascular Diseases Antibodies  >5 publications with SRD5A1 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >5 publications with SRD5A1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >5 publications with SRD5A1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >5 publications with SRD5A1 and Disease Models, Animal
 Disorders of Sex Development Antibodies  >4 publications with SRD5A1 and Disorders of Sex Development
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >44 publications with SRD5A1 and Prostate
 Blood Antibodies  >27 publications with SRD5A1 and Blood
 Ovary Antibodies  >14 publications with SRD5A1 and Ovary
 Testis Antibodies  >12 publications with SRD5A1 and Testis
 Brain Antibodies  >11 publications with SRD5A1 and Brain
 Liver Antibodies  >10 publications with SRD5A1 and Liver
 Muscle Antibodies  >10 publications with SRD5A1 and Muscle
 Uterus Antibodies  >7 publications with SRD5A1 and Uterus
 Embryonic Tissue Antibodies  >6 publications with SRD5A1 and Embryonic Tissue
 Bone Antibodies  >6 publications with SRD5A1 and Bone
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