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anti-SREBP-1 antibody :: Rabbit SREBP-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2535186
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SREBP-1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SREBP-1 Polyclonal Antibody

 Product Synonym Names    SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1
 Product Gene Name   

anti-SREBP-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    184756
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purified
 Concentration    1mg/mL (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human SREBP-1.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.1540% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-SREBP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SREBP-1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SREBP-1 antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-SREBP-1 antibody    Western Blot analysis of HeLa HepG2 cells using SREBP-1 Polyclonal Antibody
anti-SREBP-1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SREBP-1. It may not necessarily be applicable to this product.
 NCBI GI #    7144550
 NCBI GeneID    6720
 NCBI Accession #    AAC50051.2 [Other Products]
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 UniProt Secondary Accession #    Q16062; Q59F52; Q6P4R7; Q6PFW7; Q6PJ36; Q8TAK9; B0I4X3; B0I4X4; D3DXC4 [Other Products]
 UniProt Related Accession #    P36956 [Other Products]
 Molecular Weight    Calculated MW: 122
Observed MW: 120
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 NCBI Official Full Name    SREBP-1
 NCBI Official Synonym Full Names    sterol regulatory element binding transcription factor 1
 NCBI Official Symbol    SREBF1 [Similar Products]
 NCBI Official Synonym Symbols   
SREBP1; bHLHd1; SREBP1a; SREBP-1c
[Similar Products]
 NCBI Protein Information    sterol regulatory element-binding protein 1
 UniProt Protein Name    Sterol regulatory element-binding protein 1
 UniProt Synonym Protein Names   
Class D basic helix-loop-helix protein 1; bHLHd1
 UniProt Gene Name    SREBF1 [Similar Products]
 UniProt Synonym Gene Names    BHLHD1; SREBP1; SREBP-1; bHLHd1 [Similar Products]
 UniProt Entry Name    SRBP1_HUMAN
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 NCBI Summary for SREBP-1    This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SREBP-1    SREBP-1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; Golgi membrane; nuclear envelope; nucleoplasm; nucleus

Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; sterol response element binding; transcription factor activity

Biological Process: cellular response to starvation; circadian rhythm; lipid biosynthetic process; lipid metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of protein stability; regulation of transcription from RNA polymerase II promoter
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 Research Articles on SREBP-1    1. We concluded that 54(G/C) polymorphism of SREBF-1 gene is associated with polycystic ovary syndrome (PCOS) and suggest that SREBF-1 gene may play a role in genetic predisposition to PCOS.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SREBP-1 antibodyPathways associated with anti-SREBP-1 antibody
 Reference Product  PubMed Publications
 FASN antibody  >130 publications with SREBP-1 and FASN
 SCD antibody  >117 publications with SREBP-1 and SCD
 SCAP antibody  >92 publications with SREBP-1 and SCAP
 LDLR antibody  >66 publications with SREBP-1 and LDLR
 MTOR antibody  >48 publications with SREBP-1 and MTOR
 SIRT1 antibody  >41 publications with SREBP-1 and SIRT1
 MED15 antibody  >3 publications with SREBP-1 and MED15
 CREBBP antibody  >3 publications with SREBP-1 and CREBBP
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Diseases associated with anti-SREBP-1 antibodyOrgans/Tissues associated with anti-SREBP-1 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >973 publications with SREBP-1 and Fatty Liver
 Liver Diseases Antibodies  >513 publications with SREBP-1 and Liver Diseases
 Obesity Antibodies  >424 publications with SREBP-1 and Obesity
 Insulin Resistance Antibodies  >360 publications with SREBP-1 and Insulin Resistance
 Inflammation Antibodies  >164 publications with SREBP-1 and Inflammation
 Non-alcoholic Fatty Liver Disease Antibodies  >153 publications with SREBP-1 and Non-alcoholic Fatty Liver Disease
 Dyslipidemias Antibodies  >145 publications with SREBP-1 and Dyslipidemias
 Cardiovascular Diseases Antibodies  >131 publications with SREBP-1 and Cardiovascular Diseases
 Necrosis Antibodies  >117 publications with SREBP-1 and Necrosis
 Atherosclerosis Antibodies  >115 publications with SREBP-1 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1354 publications with SREBP-1 and Liver
 Blood Antibodies  >563 publications with SREBP-1 and Blood
 Connective Tissue Antibodies  >307 publications with SREBP-1 and Connective Tissue
 Muscle Antibodies  >235 publications with SREBP-1 and Muscle
 Kidney Antibodies  >99 publications with SREBP-1 and Kidney
 Vascular Antibodies  >83 publications with SREBP-1 and Vascular
 Brain Antibodies  >79 publications with SREBP-1 and Brain
 Pancreas Antibodies  >75 publications with SREBP-1 and Pancreas
 Heart Antibodies  >70 publications with SREBP-1 and Heart
 Intestine Antibodies  >52 publications with SREBP-1 and Intestine
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