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anti-SRY antibody :: Rabbit anti-Bovine SRY Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS691122
Testing Data
Unit / Price
0.1 mg  /  $275 +1 FREE 8GB USB
0.2 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SRY, Polyclonal Antibody

 Also Known As   

Rabbit Anti-Bovine SRY

 Product Synonym Names    Anti-bovine SRY; Sex-determining region Y protein; Testis-determining factor
 Product Gene Name   

anti-SRY antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; AC_000170.1 (5424637..5425326, complement). Location: chromosome: Y
 3D Structure    ModBase 3D Structure for Q03255
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 Clonality    Polyclonal
 Clone Number    Rabbit IgG
 Host    Rabbit
 Species Reactivity    Bovine
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 Purity/Purification    Protein A purified
 Form/Format    Lyophilized
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 Immunogen    Recombinant bovine SRY (RT #B30-001)
 Preparation    Produced from sera of rabbits pre-immunized with highly pure recombinant bovine SRY (Met1 - Tyr229) derived from E. coli.
 Reconstitution    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
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 Preparation and Storage    The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SRY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SRY antibody

   The "ěSex determining region of Y-Gen"Ě (SRY), known as SRY gene, is coding for a transkription factor (TDF for Testis-determining factor). It belongs to the protein family of DNA binding-proteins. The SRY gene is beside other genes used for the determination of the sex in human as well as other mammals. Most mammals have for this purpose a further gene, UBE1. In humans SRY is normally located on the short arm of the Y chromosome. Accordingly, people who possess this chromosome with the corresponding gene, normally have a male phenotype. It does not matter how many copies of the X chromosome are present, even people with a multiple X chromosome (Klinefelter\'s syndrome) have this. The protein encoded by the gene Testis-determining factor controls the development of male sex.
 Applications Tested/Suitable for anti-SRY antibody   

Western Blot (WB)

 Application Notes for anti-SRY antibody    Western Blot: Use 1-5 ug/ml
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 Testing Data of anti-SRY antibody    anti-SRY antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SRY. It may not necessarily be applicable to this product.
 NCBI GI #    62177084
 NCBI GeneID    280931
 NCBI Accession #    NP_001014407.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001014385.1 [Other Products]
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 UniProt Primary Accession #    Q03255 [Other Products]
 UniProt Secondary Accession #    A1XCJ6; A8WDV8 [Other Products]
 UniProt Related Accession #    Q03255 [Other Products]
 Molecular Weight    26,627 Da
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 NCBI Official Full Name    sex-determining region Y protein
 NCBI Official Symbol    SRY [Similar Products]
 NCBI Protein Information    sex-determining region Y protein; sex determining factor Y; testis-determining factor; sex-determining region of the Y-chromosome
 UniProt Protein Name    Sex-determining region Y protein
 UniProt Synonym Protein Names   
Testis-determining factor
 Protein Family    SRY-related protein
 UniProt Gene Name    SRY [Similar Products]
 UniProt Synonym Gene Names    TDF [Similar Products]
 UniProt Entry Name    SRY_BOVIN
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 UniProt Comments for SRY    Function: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'

By similarity.

Subunit structure: Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1

By similarity.

Subcellular location: Nucleus speckle

By similarity. Cytoplasm

By similarity.

Post-translational modification: Phosphorylation on serine residues enhances its DNA-binding activity and stimulates transcription repression. Acetylation of Lys-130 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. Poly-ADP-ribosylation reduces its DNA-binding activity

By similarity.

Sequence similarities: Belongs to the SRY family.Contains 1 HMG box DNA-binding domain.
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Product References and Citations for anti-SRY antibody

   1. Harikae K et al, J Reprod Dev 2012; 58:654-60 2. Hamilton CK et al, Theriogenology 2012; 77:1587-96 3. Gou X et al, J Anim Breed Genet 2010; 127:154-60 4. Ross DG et al, BMC Mol Biol 2008; 9:85 5. Lu W et al, Anim Reprod Sci 2007; 100:186-91
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 Research Articles on SRY    1. analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SRY antibodyDiseases associated with anti-SRY antibody
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >135 publications with SRY and Heart Diseases
 Nervous System Diseases Antibodies  >78 publications with SRY and Nervous System Diseases
 Kidney Diseases Antibodies  >37 publications with SRY and Kidney Diseases
 46,XY SEX REVERSAL 1 Antibodies  >35 publications with SRY and 46,XY SEX REVERSAL 1
 Hyperplasia Antibodies  >32 publications with SRY and Hyperplasia
 Liver Diseases Antibodies  >27 publications with SRY and Liver Diseases
 Adenocarcinoma Antibodies  >27 publications with SRY and Adenocarcinoma
 46,XX SEX REVERSAL 1 Antibodies  >26 publications with SRY and 46,XX SEX REVERSAL 1
 Necrosis Antibodies  >23 publications with SRY and Necrosis
 Hypertrophy Antibodies  >19 publications with SRY and Hypertrophy
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