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anti-TRIM21 antibody :: Sheep anti-Human SSA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS623598 anti-TRIM21 antibody
Unit / Price
0.1 mg  /  $710 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SSA1 (TRIM21), Polyclonal Antibody

 Also Known As   

SSA1 (Tripartite Motif-containing 21, 52kD Ribonucleoprotein Autoantigen Ro/SS-A, 52kD Ro Protein, RING Finger Protein 81, RNF81, Ro(SS-A), RO52, Sjoegren Syndrome Type A Antigen, SSA, SS-A, TRIM21, Tripartite Motif-containing Protein 21)

 Product Synonym Names    Anti -SSA1 (Tripartite Motif-containing 21, 52kD Ribonucleoprotein Autoantigen Ro/SS-A, 52kD Ro Protein, RING Finger Protein 81, RNF81, Ro(SS-A), RO52, Sjoegren Syndrome Type A Antigen, SSA, SS-A, TRIM21, Tripartite Motif-containing Protein 21)
 Product Gene Name   

anti-TRIM21 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (4406127..4414926, complement). Location: 11p15.5
 OMIM    109092
 3D Structure    ModBase 3D Structure for P19474
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
 Species Reactivity    Human
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 Specificity    Recognizes human SSA1.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 100ul PBS, 0.02% sodium azide.
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 Immunogen    Purified, E. coli-derived, recombinant human TRIM21 (aa1-475; Accession # P19474).
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-TRIM21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TRIM21 antibody

   TRIM21 (Tripartite motif-containing protein 21; also Ro(SS-A), 52kD Ro Protein/Ro52, and RING finger protein 81) is a 52-56kD member of the RING finger-B-box-coiled-coil family of proteins. It is an E3 ligase that is found in both nucleus and cytoplasm, where it is often associated with microtubules. TRIM21 ubiquitinates select proteins. In B cells, it targets the Fc fragment of misfolded IgG, providing QC on its production. In macrophages, it acts in a nondegradative manner on IRF8, promoting innate immunity. Human TRIM21 is 475aa in length and contains one E3 ligase RING finger domain (aa16-55), a B-Box type zinc-finger region (aa92-123), a coiled-coil region (aa128-238) and a C-terminal PRY/B30.2 Ig binding domain (aa268-465). TRIM21 is reported to form trimers. Over aa195-293, human TRIM21 exhibits 72aa identity with mouse TRIM21.
 Product Categories/Family for anti-TRIM21 antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-TRIM21 antibody   

Western Blot (WB)

 Application Notes for anti-TRIM21 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 0.5ug/ml
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NCBI/Uniprot data below describe general gene information for TRIM21. It may not necessarily be applicable to this product.
 NCBI GI #    14994115
 NCBI GeneID    6737
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 UniProt Primary Accession #    P19474 [Other Products]
 UniProt Secondary Accession #    Q5XPV5; Q96RF8 [Other Products]
 UniProt Related Accession #    P19474 [Other Products]
 Molecular Weight    54,170 Da [Similar Products]
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 NCBI Official Full Name    SSA1
 NCBI Official Synonym Full Names    tripartite motif containing 21
 NCBI Official Symbol    TRIM21 [Similar Products]
 NCBI Official Synonym Symbols   
SSA; RO52; SSA1; RNF81
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; OTTHUMP00000230775; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
 UniProt Protein Name    E3 ubiquitin-protein ligase TRIM21
 UniProt Synonym Protein Names   
52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    TRIM21 [Similar Products]
 UniProt Synonym Gene Names    RNF81; RO52; SSA1 [Similar Products]
 UniProt Entry Name    RO52_HUMAN
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 NCBI Summary for TRIM21    This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq]
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 UniProt Comments for TRIM21    TRIM21: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: nucleoplasm; cytoplasm; SCF ubiquitin ligase complex; ribonucleoprotein complex; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; zinc ion binding; RNA binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: protein monoubiquitination; regulation of interferon type I production; protein autoubiquitination; protein polyubiquitination; protein destabilization; cytokine and chemokine mediated signaling pathway; positive regulation of cell cycle; protein ubiquitination; cell cycle; negative regulation of viral transcription; positive regulation of virion penetration into host cell; inhibition of NF-kappaB transcription factor; positive regulation of interferon type I production; innate immune response; positive regulation of transcription factor activity
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 Research Articles on TRIM21    1. FADD and TRIM21 together negatively regulate the late IFN-alpha pathway in response to viral infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TRIM21 antibodyDiseases associated with anti-TRIM21 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with TRIM21 and Inflammation
 Anemia Antibodies  >4 publications with TRIM21 and Anemia
 Esophageal Neoplasms Antibodies  >1 publications with TRIM21 and Esophageal Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with TRIM21 and Carcinoma, Squamous Cell
 Neoplasms Antibodies  >1 publications with TRIM21 and Neoplasms
 Carcinoma Antibodies  >1 publications with TRIM21 and Carcinoma
Organs/Tissues associated with anti-TRIM21 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with TRIM21 and Blood
 Lung Antibodies  >2 publications with TRIM21 and Lung
 Skin Antibodies  >2 publications with TRIM21 and Skin
 Bone Antibodies  >1 publications with TRIM21 and Bone
 Bone Marrow Antibodies  >1 publications with TRIM21 and Bone Marrow
 Connective Tissue Antibodies  >1 publications with TRIM21 and Connective Tissue
 Kidney Antibodies  >1 publications with TRIM21 and Kidney
 Brain Antibodies  >1 publications with TRIM21 and Brain
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