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anti-STAM2 antibody :: Goat STAM2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421054
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAM2, Polyclonal Antibody

 Also Known As   

Goat anti-STAM2 Antibody

 Product Synonym Names    STAM2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; HGNC: 11358; DKFZp564C047; Hbp; STAM2A; STAM2B; STAM-like protein containing SH3 and ITAM domains 2; signal transducing adaptor molecule 2; STAM2 antibody; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody; HGNC: 11358 antibody; DKFZp564C047 antibody; Hbp antibody; STAM2A antibody; STAM2B antibody; STAM-like protein containing SH3 and ITAM domains 2 antibody; signal transducing adaptor molecule 2 antibody
 Product Gene Name   

anti-STAM2 antibody

[Similar Products]
 Antibody/Peptide Pairs    STAM2 peptide (MBS425121) is used for blocking the activity of STAM2 antibody (MBS421054)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QSIDPTDSKP DSQD
 OMIM    606244
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QSIDPTDSKPDSQD, from the internal region of the protein sequence according to NP_005834.3.
 Epitope    Internal region
 Note    No cross-reaction expected with STAM1.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-STAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-STAM2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-STAM2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 70kDa band observed in Human Spleen lysates (calculated MW of 58.2kDa according to NP_005834.3). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Pandey et al J Biol Chem.2000 Dec 8;275(49): 38633-9; PMID: 10993906). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-STAM2 antibody    (1ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-STAM2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for STAM2. It may not necessarily be applicable to this product.
 NCBI GI #    21265031
 NCBI GeneID    10254
 NCBI Accession #    NP_005834.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005843.3 [Other Products]
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 UniProt Secondary Accession #    Q7LDQ0; Q9UF58; A8K8A0; D3DPA1 [Other Products]
 UniProt Related Accession #    O75886 [Other Products]
 Molecular Weight    38,370 Da
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 NCBI Official Full Name    signal transducing adaptor molecule 2
 NCBI Official Synonym Full Names    signal transducing adaptor molecule 2
 NCBI Official Symbol    STAM2 [Similar Products]
 NCBI Official Synonym Symbols   
Hbp; STAM2A; STAM2B
[Similar Products]
 NCBI Protein Information    signal transducing adapter molecule 2
 UniProt Protein Name    Signal transducing adapter molecule 2
 UniProt Synonym Protein Names   
Hrs-binding protein
 Protein Family    Signal transducing adapter molecule
 UniProt Gene Name    STAM2 [Similar Products]
 UniProt Synonym Gene Names    HBP; STAM-2 [Similar Products]
 UniProt Entry Name    STAM2_HUMAN
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 NCBI Summary for STAM2    The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAM2    STAM2: an adaptor protein involved in the downstream signaling of cytokine receptors. Contain a SH3 domain and immunoreceptor tyrosine-based activation motif (ITAM). Acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. May modulate the signaling pathway downstream of JAK kinases upon cytokine stimulation.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q23.3

Cellular Component: cytoplasm; cytosol; early endosome membrane; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: protein binding

Biological Process: autophagy; endosome transport; intracellular protein transport; negative regulation of epidermal growth factor receptor signaling pathway
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 Research Articles on STAM2    1. correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-STAM2 antibodyDiseases associated with anti-STAM2 antibody
 Products by Pathway  Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 ESCRT-0 Complex Pathway antibodies  ESCRT-0 Complex Pathway Diagram
 ESCRT-0 Complex Pathway antibodies  ESCRT-0 Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 IL2-mediated Signaling Events Pathway antibodies  IL2-mediated Signaling Events Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with STAM2 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with STAM2 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with STAM2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with STAM2 and Liver Neoplasms
Organs/Tissues associated with anti-STAM2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with STAM2 and Brain
 Heart Antibodies  >3 publications with STAM2 and Heart
 Muscle Antibodies  >2 publications with STAM2 and Muscle
 Blood Antibodies  >2 publications with STAM2 and Blood
 Testis Antibodies  >2 publications with STAM2 and Testis
 Skin Antibodies  >1 publications with STAM2 and Skin
 Liver Antibodies  >1 publications with STAM2 and Liver
 Embryonic Tissue Antibodies  >1 publications with STAM2 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with STAM2 and Pancreas
 Ovary Antibodies  >1 publications with STAM2 and Ovary
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