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anti-STAMBP antibody :: Rabbit STAMBP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS621480 anti-STAMBP antibody
Unit / Price
0.02 mL  /  $385 +1 FREE 8GB USB
0.1 mL  /  $540 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAMBP, Polyclonal Antibody

 Also Known As   

STAMBP (STAM binding protein, AMSH, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, MGC126516, MGC126518)

 Product Synonym Names    Anti -STAMBP (STAM binding protein, AMSH, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, MGC126516, MGC126518)
 Product Gene Name   

anti-STAMBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (74056086..74090011). Location: 2p13.1
 OMIM    606247
 3D Structure    ModBase 3D Structure for O95630
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Monkey
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 Specificity    Recognizes endogenous levels of total STAMBP protein. Species crossreactivity: Human and monkey
 Purity/Purification    Affinity Purified
Purified by Protein A and petide affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol.
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 Immunogen    Synthetic peptide corresponding to residues surrounding Gly194 of human STAMBP protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-STAMBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STAMBP antibody

   Protein ubiquitination and deubiquitination is a reversible process catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (1,2). Deubiquitinating enzymes (DUBs) function as ubiquitin-specific proteases and can be divided into five subfamilies based on catalytic domain structure. At least 14 members of the JAMM ubiquitin protease subfamily have been identified, including signal transducing adaptor molecule (STAM) binding protein (3). STAM-binding protein (STAMBP or AMSH) is an endosomal DUB that preferentially displays ubiquitin isopeptidase activity toward K63-linked chains, which is critically dependent upon its interaction with STAM (4,5). STAMBP interacts with the STAM adaptor protein and becomes integrated into the multivesicular body sorting machinery to help regulate endosomal trafficking and receptor tyrosine kinase stability by deubiquitining target proteins (4,6). Evidence indicates that endosomal STAMBP antagonizes the ubiquitin-dependent trafficking of EGFR to the lysosomal compartment (7).
 Product Categories/Family for anti-STAMBP antibody    Antibodies; Abs to Ubiquitin
 Applications Tested/Suitable for anti-STAMBP antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-STAMBP antibody    Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:50
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NCBI/Uniprot data below describe general gene information for STAMBP. It may not necessarily be applicable to this product.
 NCBI GI #    42519912
 NCBI GeneID    10617
 NCBI Accession #    NP_964010.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_201647.2 [Other Products]
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 UniProt Primary Accession #    O95630 [Other Products]
 UniProt Secondary Accession #    Q3MJE7; D6W5H7 [Other Products]
 UniProt Related Accession #    O95630 [Other Products]
 Molecular Weight    48,077 Da [Similar Products]
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 NCBI Official Full Name    STAM-binding protein
 NCBI Official Synonym Full Names    STAM binding protein
 NCBI Official Symbol    STAMBP [Similar Products]
 NCBI Official Synonym Symbols   
AMSH; MGC126516; MGC126518
[Similar Products]
 NCBI Protein Information    STAM-binding protein; OTTHUMP00000160249; OTTHUMP00000202512; OTTHUMP00000202513; endosome-associated ubiquitin isopeptidase; associated molecule with the SH3 domain of STAM
 UniProt Protein Name    STAM-binding protein
 UniProt Synonym Protein Names   
Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
 Protein Family    STAM-binding protein
 UniProt Gene Name    STAMBP [Similar Products]
 UniProt Synonym Gene Names    AMSH [Similar Products]
 UniProt Entry Name    STABP_HUMAN
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 NCBI Summary for STAMBP    Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq]
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 UniProt Comments for STAMBP    AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression.

Protein type: Protease; Ubiquitin-specific protease; EC 3.4.19.-; EC

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: nucleoplasm; early endosome; cytoplasm; plasma membrane; nucleus; cleavage furrow

Molecular Function: protein domain specific binding; protein binding; metallopeptidase activity; metal ion binding; ubiquitin-specific protease activity

Biological Process: protein deubiquitination; cytokinesis after mitosis; positive regulation of cell proliferation; negative regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; proteolysis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade

Disease: Microcephaly-capillary Malformation Syndrome
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 Research Articles on STAMBP    1. AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAMBP antibodyPathways associated with anti-STAMBP antibody
 Reference Product  PubMed Publications
 STAM antibody  >14 publications with STAMBP and STAM
 VPS24 antibody  >5 publications with STAMBP and VPS24
 CHMP1A antibody  >3 publications with STAMBP and CHMP1A
 GRB2 antibody  >2 publications with STAMBP and GRB2
 CHMP1B antibody  >2 publications with STAMBP and CHMP1B
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram
Diseases associated with anti-STAMBP antibodyOrgans/Tissues associated with anti-STAMBP antibody
 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >1 publications with STAMBP and Central Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with STAMBP and Brain
 Testis Antibodies  >1 publications with STAMBP and Testis
 Embryonic Tissue Antibodies  >1 publications with STAMBP and Embryonic Tissue
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