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anti-STAR antibody :: Rabbit STAR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126761
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAR, Polyclonal Antibody

 Also Known As   

STAR Polyclonal Antibody

 Product Synonym Names    STAR; STARD1
 Product Gene Name   

anti-STAR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 600617
 3D Structure    ModBase 3D Structure for P49675
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human STAR
 Calculated Molecular Weight    32kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-STAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STAR antibody

   Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane (1). The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone (2,3). StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue (3). Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis (4). The mechanism of cholesterol binding to StAR has yet to be elucidated (4).
 Product Categories/Family for anti-STAR antibody    Polyclonal
 Applications Tested/Suitable for anti-STAR antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-STAR antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-STAR antibody    Western blot analysis of extracts of various cell lines, using STAR antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
anti-STAR antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-STAR antibody    Immunofluorescence analysis of U2OS cells using STAR antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
anti-STAR antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for STAR. It may not necessarily be applicable to this product.
 NCBI GI #    71152974
 NCBI GeneID    6770
 NCBI Accession #    P49675.2 [Other Products]
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 UniProt Primary Accession #    P49675 [Other Products]
 UniProt Secondary Accession #    Q16396 [Other Products]
 UniProt Related Accession #    P49675 [Other Products]
 Molecular Weight    285
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 NCBI Official Full Name    Steroidogenic acute regulatory protein, mitochondrial
 NCBI Official Synonym Full Names    steroidogenic acute regulatory protein
 NCBI Official Symbol    STAR [Similar Products]
 NCBI Official Synonym Symbols   
STARD1
[Similar Products]
 NCBI Protein Information    steroidogenic acute regulatory protein, mitochondrial; cholesterol trafficker; START domain containing 1; steroid acute regulatory protein; START domain-containing protein 1; mitochondrial steroid acute regulatory protein; StAR-related lipid transfer (START) domain containing 1
 UniProt Protein Name    Steroidogenic acute regulatory protein, mitochondrial
 UniProt Synonym Protein Names   
START domain-containing protein 1; StARD1
 Protein Family    Starch synthase
 UniProt Gene Name    STAR [Similar Products]
 UniProt Synonym Gene Names    STARD1; StAR; StARD1 [Similar Products]
 UniProt Entry Name    STAR_HUMAN
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 NCBI Summary for STAR    The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAR    STAR: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney.

Protein type: Mitochondrial; Lipid-binding; Carrier

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: mitochondrial crista; neuron projection; cell soma; mitochondrial intermembrane space; cytosol

Molecular Function: cholesterol transporter activity; cholesterol binding

Biological Process: response to nicotine; steroid metabolic process; diterpenoid metabolic process; dibenzo-p-dioxin metabolic process; regulation of steroid biosynthetic process; estrogen biosynthetic process; biphenyl metabolic process; circadian sleep/wake cycle, REM sleep; negative regulation of neuron apoptosis; response to nutrient; response to corticosterone stimulus; response to drug; cholesterol metabolic process; bile acid biosynthetic process; positive regulation of neurogenesis; insecticide metabolic process; progesterone biosynthetic process; fractalkine metabolic process; male gonad development; phthalate metabolic process; intracellular cholesterol transport; response to herbicide; glucocorticoid metabolic process; response to ethanol; response to hydrogen peroxide; cellular response to insulin stimulus; response to estrogen stimulus; response to lead ion; C21-steroid hormone biosynthetic process; brain development; response to activity; response to ionizing radiation; steroid biosynthetic process; regulation of neuronal synaptic plasticity; phenol metabolic process

Disease: Lipoid Congenital Adrenal Hyperplasia
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 Research Articles on STAR    1. StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON protease and the inner membrane complexes of the metalloproteases AFG3L2 and AFG3L2:SPG7/paraplegin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAR antibodyPathways associated with anti-STAR antibody
 Reference Product  PubMed Publications
 POMC antibody  >123 publications with STAR and POMC
 PTGS2 antibody  >48 publications with STAR and PTGS2
 NR0B1 antibody  >44 publications with STAR and NR0B1
 GATA4 antibody  >27 publications with STAR and GATA4
 IGF1 antibody  >20 publications with STAR and IGF1
 NR5A2 antibody  >16 publications with STAR and NR5A2
 SREBF1 antibody  >13 publications with STAR and SREBF1
 INS antibody  >9 publications with STAR and INS
 GATA6 antibody  >7 publications with STAR and GATA6
 LIPE antibody  >2 publications with STAR and LIPE
 Products by Pathway  Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Pregnenolone Biosynthesis Pathway antibodies  Pregnenolone Biosynthesis Pathway Diagram
Diseases associated with anti-STAR antibodyOrgans/Tissues associated with anti-STAR antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >406 publications with STAR and Cardiovascular Diseases
 Brain Diseases Antibodies  >339 publications with STAR and Brain Diseases
 Inflammation Antibodies  >230 publications with STAR and Inflammation
 Kidney Diseases Antibodies  >186 publications with STAR and Kidney Diseases
 Heart Diseases Antibodies  >183 publications with STAR and Heart Diseases
 Breast Neoplasms Antibodies  >173 publications with STAR and Breast Neoplasms
 Pain Antibodies  >171 publications with STAR and Pain
 Hyperplasia Antibodies  >160 publications with STAR and Hyperplasia
 Necrosis Antibodies  >133 publications with STAR and Necrosis
 Genital Diseases, Male Antibodies  >128 publications with STAR and Genital Diseases, Male
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >761 publications with STAR and Brain
 Ovary Antibodies  >520 publications with STAR and Ovary
 Testis Antibodies  >481 publications with STAR and Testis
 Eye Antibodies  >453 publications with STAR and Eye
 Kidney Antibodies  >305 publications with STAR and Kidney
 Muscle Antibodies  >301 publications with STAR and Muscle
 Adrenal Gland Antibodies  >281 publications with STAR and Adrenal Gland
 Skin Antibodies  >258 publications with STAR and Skin
 Lung Antibodies  >177 publications with STAR and Lung
 Embryonic Tissue Antibodies  >164 publications with STAR and Embryonic Tissue
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