P42224.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,043 Da
NCBI Official Full Name
Signal transducer and activator of transcription 1-alpha/beta
NCBI Official Synonym Full Names
signal transducer and activator of transcription 1, 91kDa
NCBI Official Synonym Symbols
CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91 [Similar Products]
NCBI Protein Information
signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; signal transducer and activator of transcription 1, 91kD
UniProt Protein Name
Signal transducer and activator of transcription 1-alpha/beta
UniProt Synonym Protein Names
Transcription factor ISGF-3 components p91/p84
UniProt Entry Name
STAT1_HUMAN
NCBI Summary for STAT1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for STAT1
STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component: nucleoplasm; axon; nuclear chromatin; dendrite; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; signal transducer activity; enzyme binding; protein homodimerization activity; double-stranded DNA binding; tumor necrosis factor receptor binding; transcription factor activity; CCR5 chemokine receptor binding
Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; positive regulation of mesenchymal cell proliferation; negative regulation of viral protein levels in host cell; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; cellular response to insulin stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter
Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
Research Articles on STAT1
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Products associated with anti-STAT1 antibody
Pathways associated with anti-STAT1 antibody
Diseases associated with anti-STAT1 antibody
Organs/Tissues associated with anti-STAT1 antibody
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