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anti-STAT2 antibody :: Rabbit STAT2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8201773 anti-STAT2 antibody
Unit / Price
0.03 mL  /  $165 +1 FREE 8GB USB
0.1 mL  /  $245 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAT2, Polyclonal Antibody

 Also Known As   

Anti-STAT2 (pY690) Antibody

 Product Synonym Names    Signal transducer and activator of transcription 2; p113
 Product Gene Name   

anti-STAT2 antibody

[Similar Products]
 Antibody/Peptide Pairs    STAT2 peptide (MBS8218202) is used for blocking the activity of STAT2 antibody (MBS8201773)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600556
 3D Structure    ModBase 3D Structure for P52630
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey
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 Specificity    Recognizes endogenous levels of STAT2 (pY690) protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human STAT2 (pY690). The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-STAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STAT2 antibody

   Rabbit polyclonal antibody to STAT2 (pY690)
 Applications Tested/Suitable for anti-STAT2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-STAT2 antibody    WB (1/500 - 1/1000), IHC (1/100 - 1/200)
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NCBI/Uniprot data below describe general gene information for STAT2. It may not necessarily be applicable to this product.
 NCBI GI #    4885615
 NCBI GeneID    6773
 NCBI Accession #    NP_005410.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005419.3 [Other Products]
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 UniProt Primary Accession #    P52630 [Other Products]
 UniProt Secondary Accession #    Q16430; Q16431; Q9UDL4; B4DLC7; G3V2M6 [Other Products]
 UniProt Related Accession #    P52630 [Other Products]
 Molecular Weight    97,457 Da
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 NCBI Official Full Name    signal transducer and activator of transcription 2 isoform 1
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 2, 113kDa
 NCBI Official Symbol    STAT2 [Similar Products]
 NCBI Official Synonym Symbols   
P113; ISGF-3; STAT113
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 2
 UniProt Protein Name    Signal transducer and activator of transcription 2
 UniProt Synonym Protein Names   
p113
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    STAT2 [Similar Products]
 UniProt Entry Name    STAT2_HUMAN
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 NCBI Summary for STAT2    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
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 UniProt Comments for STAT2    STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: identical protein binding; protein binding; signal transducer activity; DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; defense response to virus
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 Research Articles on STAT2    1. Respiratory syncytial virus NS1 upregulates SOCS1 expression in a RIG-I- and TLR3-independent pathway, to inhibit STAT2 phosphorylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAT2 antibodyPathways associated with anti-STAT2 antibody
 Reference Product  PubMed Publications
 STAT1 antibody  >636 publications with STAT2 and STAT1
 IFNA2 antibody  >292 publications with STAT2 and IFNA2
 JAK1 antibody  >155 publications with STAT2 and JAK1
 IRF9 antibody  >130 publications with STAT2 and IRF9
 TYK2 antibody  >120 publications with STAT2 and TYK2
 JAK2 antibody  >75 publications with STAT2 and JAK2
 IFNAR1 antibody  >55 publications with STAT2 and IFNAR1
 IFNAR2 antibody  >29 publications with STAT2 and IFNAR2
 CREBBP antibody  >7 publications with STAT2 and CREBBP
 EP300 antibody  >4 publications with STAT2 and EP300
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-STAT2 antibodyOrgans/Tissues associated with anti-STAT2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >49 publications with STAT2 and Liver Diseases
 Inflammation Antibodies  >44 publications with STAT2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >26 publications with STAT2 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >26 publications with STAT2 and Necrosis
 Liver Neoplasms Antibodies  >24 publications with STAT2 and Liver Neoplasms
 Nervous System Diseases Antibodies  >23 publications with STAT2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >20 publications with STAT2 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >14 publications with STAT2 and Neoplasms, Experimental
 Lung Diseases Antibodies  >12 publications with STAT2 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >12 publications with STAT2 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >130 publications with STAT2 and Blood
 Liver Antibodies  >58 publications with STAT2 and Liver
 Lung Antibodies  >29 publications with STAT2 and Lung
 Brain Antibodies  >29 publications with STAT2 and Brain
 Bone Antibodies  >26 publications with STAT2 and Bone
 Bone Marrow Antibodies  >24 publications with STAT2 and Bone Marrow
 Muscle Antibodies  >23 publications with STAT2 and Muscle
 Skin Antibodies  >22 publications with STAT2 and Skin
 Kidney Antibodies  >14 publications with STAT2 and Kidney
 Heart Antibodies  >14 publications with STAT2 and Heart
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