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anti-STAT3 antibody :: Rabbit STAT3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175452
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAT3, Polyclonal Antibody

 Also Known As   

Anti-STAT3 antibody

 Product Synonym Names    Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3(acute-phase response factor); 1110034C02Rik antibody; Acute Phase Response Factor antibody; Acute-phase response factor antibody; APRF antibody; AW109958 antibody; DNA binding protein APRF antibody; FLJ20882 antibody; HIES antibody; MGC16063 antibody; Signal transducer and activator of transcription 3 antibody; Signal Transductor and Activator of Transcription 3 antibody; STAT 3 antibody; Stat3 antibody; STAT3_HUMAN antibody
 Product Gene Name   

anti-STAT3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 147060
 3D Structure    ModBase 3D Structure for P40763
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human STAT3 (686-698aa YCRPESQEHPEAD), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-STAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STAT3 antibody

   Description: Rabbit IgG polyclonal antibody for Signal transducer and activator of transcription 3(STAT3) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: The transcription factor, signal transducer and activator of transcription-3(STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription(STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21, it contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.
 Applications Tested/Suitable for anti-STAT3 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

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 Western Blot (WB) of anti-STAT3 antibody    Anti-STAT3 antibody, MBS175452, Western blotting
WB: Rat Brain Tissue Lysate
anti-STAT3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-STAT3 antibody    Anti-STAT3 antibody, MBS175452, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-STAT3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for STAT3. It may not necessarily be applicable to this product.
 NCBI GI #    48429227
 NCBI GeneID    6774
 NCBI Accession #    P40763.2 [Other Products]
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 UniProt Primary Accession #    P40763 [Other Products]
 UniProt Secondary Accession #    O14916; Q9BW54; A8K7B8; K7ENL3 [Other Products]
 UniProt Related Accession #    P40763 [Other Products]
 Molecular Weight    83,126 Da
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 NCBI Official Full Name    Signal transducer and activator of transcription 3
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 3 (acute-phase response factor)
 NCBI Official Symbol    STAT3 [Similar Products]
 NCBI Official Synonym Symbols   
APRF; HIES; ADMIO
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor
 UniProt Protein Name    Signal transducer and activator of transcription 3
 UniProt Synonym Protein Names   
Acute-phase response factor
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    STAT3 [Similar Products]
 UniProt Synonym Gene Names    APRF [Similar Products]
 UniProt Entry Name    STAT3_HUMAN
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 NCBI Summary for STAT3    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAT3    STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor; Nuclear receptor co-regulator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: nucleoplasm; mitochondrial inner membrane; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein dimerization activity; signal transducer activity; protein binding; ligand-dependent nuclear receptor activity; DNA binding; sequence-specific DNA binding; transcription factor binding; protein phosphatase binding; transcription factor activity; protein kinase binding; glucocorticoid receptor binding; CCR5 chemokine receptor binding

Biological Process: transcription from RNA polymerase II promoter; viral reproduction; nerve growth factor receptor signaling pathway; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; radial glial cell differentiation; thermoregulation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; glucose homeostasis; response to estradiol stimulus; negative regulation of cell proliferation; astrocyte differentiation; regulation of transcription, DNA-dependent; protein import into nucleus; acute-phase response; negative regulation of glycolysis; positive regulation of Notch signaling pathway; response to drug; nervous system development; intracellular receptor-mediated signaling pathway; eating behavior; cytokine and chemokine mediated signaling pathway; regulation of multicellular organism growth; JAK-STAT cascade; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; cell proliferation; response to ethanol; sexual reproduction; positive regulation of transcription from RNA polymerase II promoter; eye photoreceptor cell differentiation; cell motility; phosphorylation

Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant; Autoimmune Disease, Multisystem, Infantile-onset
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 Research Articles on STAT3    1. Inactivation of Stat3-Bcl-2 pathway contributes to metformin-induced growth inhibition of esophageal squamous cell carcinoma by facilitating crosstalk between apoptosis and autophagy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAT3 antibodyPathways associated with anti-STAT3 antibody
 Reference Product  PubMed Publications
 STAT1 antibody  >1737 publications with STAT3 and STAT1
 JAK2 antibody  >1432 publications with STAT3 and JAK2
 SRC antibody  >784 publications with STAT3 and SRC
 JAK1 antibody  >591 publications with STAT3 and JAK1
 CCND1 antibody  >483 publications with STAT3 and CCND1
 EGFR antibody  >447 publications with STAT3 and EGFR
 MTOR antibody  >225 publications with STAT3 and MTOR
 PIAS3 antibody  >88 publications with STAT3 and PIAS3
 LEP antibody  >16 publications with STAT3 and LEP
 EP300 antibody  >10 publications with STAT3 and EP300
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
Diseases associated with anti-STAT3 antibodyOrgans/Tissues associated with anti-STAT3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1780 publications with STAT3 and Inflammation
 Carcinoma Antibodies  >1504 publications with STAT3 and Carcinoma
 Necrosis Antibodies  >807 publications with STAT3 and Necrosis
 Adenocarcinoma Antibodies  >673 publications with STAT3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >486 publications with STAT3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >473 publications with STAT3 and Neoplasms, Experimental
 Autoimmune Diseases Antibodies  >401 publications with STAT3 and Autoimmune Diseases
 Liver Neoplasms Antibodies  >396 publications with STAT3 and Liver Neoplasms
 Lung Neoplasms Antibodies  >351 publications with STAT3 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >315 publications with STAT3 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2710 publications with STAT3 and Blood
 Liver Antibodies  >1299 publications with STAT3 and Liver
 Brain Antibodies  >1063 publications with STAT3 and Brain
 Vascular Antibodies  >944 publications with STAT3 and Vascular
 Lung Antibodies  >795 publications with STAT3 and Lung
 Muscle Antibodies  >786 publications with STAT3 and Muscle
 Bone Antibodies  >730 publications with STAT3 and Bone
 Heart Antibodies  >568 publications with STAT3 and Heart
 Skin Antibodies  >495 publications with STAT3 and Skin
 Bone Marrow Antibodies  >483 publications with STAT3 and Bone Marrow
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