P42226.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,748 Da
NCBI Official Full Name
Signal transducer and activator of transcription 6
NCBI Official Synonym Full Names
signal transducer and activator of transcription 6, interleukin-4 induced
NCBI Official Synonym Symbols
STAT6B; STAT6C; D12S1644; IL-4-STAT [Similar Products]
NCBI Protein Information
signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT
UniProt Protein Name
Signal transducer and activator of transcription 6
UniProt Synonym Protein Names
IL-4 Stat
UniProt Entry Name
STAT6_HUMAN
NCBI Summary for STAT6
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for STAT6
STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: nucleoplasm; nuclear chromatin; cytoplasm; cytosol; lipid raft
Molecular Function: identical protein binding; signal transducer activity; protein binding; protein phosphatase binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; T-helper 1 cell lineage commitment; negative regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; mammary gland epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation
Research Articles on STAT6
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Products associated with anti-STAT6 antibody
Pathways associated with anti-STAT6 antibody
Diseases associated with anti-STAT6 antibody
Organs/Tissues associated with anti-STAT6 antibody
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