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anti-STAU1 antibody :: Rabbit STAU1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150484
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAU1, Polyclonal Antibody

★Popular Item★
 Also Known As   

STAU1 Antibody

 Product Synonym Names    STAU1; STAU; STAU; Double-stranded RNA-binding protein Staufen homolog 1; staufen, RNA binding protein, homolog 1 (Drosophila)
 Product Gene Name   

anti-STAU1 antibody

[Similar Products]
 Antibody/Peptide Pairs    STAU1 peptide (MBS152456) is used for blocking the activity of STAU1 antibody (MBS150484)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601716
 3D Structure    ModBase 3D Structure for O95793
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    STAU1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    STAU1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human STAU1.
 Buffer    STAU1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    STAU1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-STAU1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-STAU1 antibody

   STAU1 Antibody: STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.
 Applications Tested/Suitable for anti-STAU1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-STAU1 antibody    STAU1 antibody can be used for detection of STAU1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-STAU1 antibody    Western blot analysis of STAU1 in rat brain tissue lysate with STAU1 antibody at (A) 1 and (B) 2 μg/mL.
anti-STAU1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-STAU1 antibody    Immunofluorescence of STAU1 in Human Brain cells with STAU1 antibody at 20 μg/mL.
anti-STAU1 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-STAU1 antibody    Immunohistochemistry of STAU1 in human brain tissue with STAU1 antibody at 10 μg/mL.
anti-STAU1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for STAU1. It may not necessarily be applicable to this product.
 NCBI GI #    82659087
 NCBI GeneID    6780
 NCBI Accession #    NP_059347 [Other Products]
 NCBI GenBank Nucleotide #    NM_017453.2 [Other Products]
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 UniProt Primary Accession #    O95793 [Other Products]
 UniProt Secondary Accession #    Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2; A8K9Z4; E1P5Y1; E1P608 [Other Products]
 UniProt Related Accession #    O95793 [Other Products]
 Molecular Weight    55,635 Da
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 NCBI Official Full Name    double-stranded RNA-binding protein Staufen homolog 1 isoform b
 NCBI Official Synonym Full Names    staufen double-stranded RNA binding protein 1
 NCBI Official Symbol    STAU1 [Similar Products]
 NCBI Official Synonym Symbols   
STAU; PPP1R150
[Similar Products]
 NCBI Protein Information    double-stranded RNA-binding protein Staufen homolog 1; staufen, RNA binding protein, homolog 1; protein phosphatase 1, regulatory subunit 150
 UniProt Protein Name    Double-stranded RNA-binding protein Staufen homolog 1
 Protein Family    Double-stranded RNA-binding protein
 UniProt Gene Name    STAU1 [Similar Products]
 UniProt Synonym Gene Names    STAU [Similar Products]
 UniProt Entry Name    STAU1_HUMAN
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 NCBI Summary for STAU1    Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAU1    STAU: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: microtubule associated complex; rough endoplasmic reticulum; membrane; cell soma; endoplasmic reticulum; stress granule; dendrite; cytoplasm

Molecular Function: protein binding; double-stranded RNA binding; protein phosphatase 1 binding

Biological Process: intracellular mRNA localization; positive regulation of viral genome replication; positive regulation of viral protein levels in host cell
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 Research Articles on STAU1    1. TINCR, together with Staufen1, seems to stabilize a subset of mRNAs required for epidermal differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAU1 antibodyDiseases associated with anti-STAU1 antibody
 Reference Product  PubMed Publications
 UPF1 antibody  >16 publications with STAU1 and UPF1
 FMR1 antibody  >3 publications with STAU1 and FMR1
 CASC3 antibody  >1 publications with STAU1 and CASC3
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with STAU1 and Carcinoma
 Adenocarcinoma Antibodies  >2 publications with STAU1 and Adenocarcinoma
 Embryo Loss Antibodies  >1 publications with STAU1 and Embryo Loss
 Congenital Abnormalities Antibodies  >1 publications with STAU1 and Congenital Abnormalities
 Neoplasm Metastasis Antibodies  >1 publications with STAU1 and Neoplasm Metastasis
Organs/Tissues associated with anti-STAU1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with STAU1 and Brain
 Nerve Antibodies  >11 publications with STAU1 and Nerve
 Muscle Antibodies  >7 publications with STAU1 and Muscle
 Skin Antibodies  >3 publications with STAU1 and Skin
 Kidney Antibodies  >3 publications with STAU1 and Kidney
 Liver Antibodies  >2 publications with STAU1 and Liver
 Intestine Antibodies  >2 publications with STAU1 and Intestine
 Blood Antibodies  >2 publications with STAU1 and Blood
 Heart Antibodies  >2 publications with STAU1 and Heart
 Pancreas Antibodies  >1 publications with STAU1 and Pancreas
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