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anti-PTPN5 antibody :: Rabbit anti-Human, mouse STEP / PTPN5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9204706
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STEP / PTPN5, Polyclonal Antibody

★Popular Item★
 Also Known As   

STEP / PTPN5 Antibody (N-Term)

 Product Synonym Names    Tyrosine-protein phosphatase non-receptor type 5; Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP; PTPN5
 Product Gene Name   

anti-PTPN5 antibody

[Similar Products]
 Antibody/Peptide Pairs    STEP / PTPN5 peptide (MBS9227633) is used for blocking the activity of STEP / PTPN5 antibody (MBS9204706)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    168-198
 OMIM    176879
 3D Structure    ModBase 3D Structure for P54829
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This STEP / PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Function    May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
  Cellular Location    Endoplasmic reticulum membrane; Multi-pass membrane protein
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-PTPN5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTPN5 antibody

   STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90% identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons.
 Product Categories/Family for anti-PTPN5 antibody    Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-PTPN5 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-PTPN5 antibody    WB~~1:1000
IHC-P~~1:10~50
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 Western Blot (WB) of anti-PTPN5 antibody    Western blot analysis of hSTEP-Q155 in mouse brain tissue lysates (35ug/lane). STEP (arrow) was detected using the purified Pab
anti-PTPN5 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-PTPN5 antibody    Western blot analysis of hSTEP-Q155 in HepG2 cell line lysates (35ug/lane). STEP (arrow) was detected using the purified Pab.
anti-PTPN5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PTPN5 antibody    Formalin-fixed and paraffin-embedded human brain tissue reacted with STEP antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-PTPN5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTPN5. It may not necessarily be applicable to this product.
 NCBI GI #    90652861
 NCBI GeneID    84867
 NCBI Accession #    NP_001035059.1 [Other Products]
 NCBI Related Accession #    NP_001265165.1; NP_001265167.1; NP_001265168.1; NP_008837.1; NP_116170.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039970.1 [Other Products]
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 UniProt Primary Accession #    P54829 [Other Products]
 UniProt Secondary Accession #    Q6P1Z2; Q8N2A1; Q8NDP8; B3KXG7; B7Z386; B7ZAF5; D3DQY7 [Other Products]
 UniProt Related Accession #    P54829 [Other Products]
 Molecular Weight    63538
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 5 isoform b
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
 NCBI Official Symbol    PTPN5 [Similar Products]
 NCBI Official Synonym Symbols   
STEP; PTPSTEP
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 5
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 5
 UniProt Synonym Protein Names   
Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    PTPN5 [Similar Products]
 UniProt Synonym Gene Names    STEP [Similar Products]
 UniProt Entry Name    PTN5_HUMAN
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 UniProt Comments for PTPN5    STEP: a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: phosphotyrosine binding; protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation
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Product References and Citations for anti-PTPN5 antibody

   Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Li, X., et al., Genomics 28(3):442-449 (1995).
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 Research Articles on PTPN5    1. Decreased STEP protein activation in corpus striatum contributes to early enhanced apoptotic signaling in YAC model transgenic mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTPN5 antibodyDiseases associated with anti-PTPN5 antibody
 Reference Product  PubMed Publications
 FYN antibody  >10 publications with PTPN5 and FYN
 MAPK3 antibody  >9 publications with PTPN5 and MAPK3
 MAPK1 antibody  >9 publications with PTPN5 and MAPK1
 MAPK14 antibody  >2 publications with PTPN5 and MAPK14
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >20 publications with PTPN5 and Mental Disorders
 Disease Models, Animal Antibodies  >13 publications with PTPN5 and Disease Models, Animal
 Cognition Disorders Antibodies  >5 publications with PTPN5 and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >3 publications with PTPN5 and Neurobehavioral Manifestations
 Seizures Antibodies  >3 publications with PTPN5 and Seizures
 Pain Antibodies  >2 publications with PTPN5 and Pain
 Necrosis Antibodies  >1 publications with PTPN5 and Necrosis
 Learning Disorders Antibodies  >1 publications with PTPN5 and Learning Disorders
 Anxiety Disorders Antibodies  >1 publications with PTPN5 and Anxiety Disorders
 Brain Injuries Antibodies  >1 publications with PTPN5 and Brain Injuries
Organs/Tissues associated with anti-PTPN5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with PTPN5 and Brain
 Eye Antibodies  >2 publications with PTPN5 and Eye
 Embryonic Tissue Antibodies  >1 publications with PTPN5 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PTPN5 and Kidney
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