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anti-STIM1 antibody :: Rabbit STIM1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150530
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STIM1, Polyclonal Antibody

 Also Known As   

STIM1 Antibody

 Product Synonym Names    STIM1; GOK; TAM; IMD10; D11S4896E; GOK; Stromal interaction molecule 1; stromal interaction molecule 1
 Product Gene Name   

anti-STIM1 antibody

[Similar Products]
 Antibody/Peptide Pairs    STIM1 peptide (MBS152297) is used for blocking the activity of STIM1 antibody (MBS150530)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615887
 3D Structure    ModBase 3D Structure for Q13586
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least two isoforms of STIM1 are known to exist; this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.
 Purity/Purification    STIM1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    STIM1 antibody was raised against a 24 amino acid synthetic peptide from near the carboxy terminus of human STIM1.
 Buffer    STIM1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    STIM1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-STIM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STIM1 antibody

   STIM1 Antibody: In T lymphocytes, the sole pathway for Ca2+ entry following antigen-receptor binding is through store-operated Ca2+-release-activated Ca2+ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca2+ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca2+ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca2+ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca2+ entry.
 Applications Tested/Suitable for anti-STIM1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-STIM1 antibody    STIM1 antibody can be used for detection of STIM1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.
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 Western Blot (WB) of anti-STIM1 antibody    Western blot analysis of STIM1 in mouse thymus tissue lysate with STIM1 antibody at (A) 1 and (B) 2 μg/mL.
anti-STIM1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-STIM1 antibody    Immunohistochemistry of STIM1 in human spleen tissue with STIM1 antibody at 2.5 μg/mL.
anti-STIM1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for STIM1. It may not necessarily be applicable to this product.
 NCBI GI #    21070997
 NCBI GeneID    6786
 NCBI Accession #    NP_003147 [Other Products]
 NCBI GenBank Nucleotide #    NM_003156.3 [Other Products]
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 UniProt Primary Accession #    Q13586 [Other Products]
 UniProt Secondary Accession #    Q8N382; E9PQJ4 [Other Products]
 UniProt Related Accession #    Q13586 [Other Products]
 Molecular Weight    Predicted: 59; 75; 87 kDa

Observed: 88 kDa
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 NCBI Official Full Name    stromal interaction molecule 1 isoform 2
 NCBI Official Synonym Full Names    stromal interaction molecule 1
 NCBI Official Symbol    STIM1 [Similar Products]
 NCBI Official Synonym Symbols   
GOK; TAM; TAM1; IMD10; STRMK; D11S4896E
[Similar Products]
 NCBI Protein Information    stromal interaction molecule 1
 UniProt Protein Name    Stromal interaction molecule 1
 Protein Family    Stromal interaction molecule
 UniProt Gene Name    STIM1 [Similar Products]
 UniProt Synonym Gene Names    GOK [Similar Products]
 UniProt Entry Name    STIM1_HUMAN
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 NCBI Summary for STIM1    This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
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 UniProt Comments for STIM1    STIM1: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. Forms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1. Ubiquitously expressed in various human primary cells and tumor cell lines.

Protein type: Membrane protein, integral; Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: microtubule; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; integral to endoplasmic reticulum membrane

Molecular Function: identical protein binding; microtubule plus-end binding; protein binding; calcium ion binding

Biological Process: activation of store-operated calcium channel activity; calcium ion transport; detection of calcium ion; regulation of calcium ion transport; blood coagulation

Disease: Myopathy, Tubular Aggregate, 1; Immunodeficiency 10
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 Research Articles on STIM1    1. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STIM1 antibodyPathways associated with anti-STIM1 antibody
 Reference Product  PubMed Publications
 ORAI1 antibody  >578 publications with STIM1 and ORAI1
 TRPC1 antibody  >114 publications with STIM1 and TRPC1
 ORAI3 antibody  >75 publications with STIM1 and ORAI3
 ORAI2 antibody  >48 publications with STIM1 and ORAI2
 TRPC4 antibody  >24 publications with STIM1 and TRPC4
 TRPC5 antibody  >15 publications with STIM1 and TRPC5
 ITPR3 antibody  >2 publications with STIM1 and ITPR3
 CDON antibody  >1 publications with STIM1 and CDON
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 Platelet Calcium Homeostasis Pathway antibodies  Platelet Calcium Homeostasis Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
Diseases associated with anti-STIM1 antibodyOrgans/Tissues associated with anti-STIM1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >48 publications with STIM1 and Cardiovascular Diseases
 Inflammation Antibodies  >33 publications with STIM1 and Inflammation
 Disease Models, Animal Antibodies  >27 publications with STIM1 and Disease Models, Animal
 Necrosis Antibodies  >16 publications with STIM1 and Necrosis
 Hypertension Antibodies  >13 publications with STIM1 and Hypertension
 Fibrosis Antibodies  >10 publications with STIM1 and Fibrosis
 Stroke Antibodies  >10 publications with STIM1 and Stroke
 Hyperplasia Antibodies  >8 publications with STIM1 and Hyperplasia
 Kidney Diseases Antibodies  >8 publications with STIM1 and Kidney Diseases
 Pain Antibodies  >6 publications with STIM1 and Pain
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >157 publications with STIM1 and Blood
 Muscle Antibodies  >150 publications with STIM1 and Muscle
 Vascular Antibodies  >88 publications with STIM1 and Vascular
 Brain Antibodies  >61 publications with STIM1 and Brain
 Heart Antibodies  >40 publications with STIM1 and Heart
 Kidney Antibodies  >39 publications with STIM1 and Kidney
 Lung Antibodies  >38 publications with STIM1 and Lung
 Bone Antibodies  >24 publications with STIM1 and Bone
 Liver Antibodies  >22 publications with STIM1 and Liver
 Nerve Antibodies  >22 publications with STIM1 and Nerve
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