NP_938023
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,193 Da
NCBI Official Full Name
stimulator of interferon genes protein isoform 1
NCBI Official Synonym Full Names
transmembrane protein 173
NCBI Official Synonym Symbols
ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING [Similar Products]
NCBI Protein Information
stimulator of interferon genes protein
UniProt Protein Name
Stimulator of interferon genes protein
UniProt Synonym Protein Names
Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173
UniProt Synonym Gene Names
UniProt Entry Name
STING_HUMAN
NCBI Summary for STING / TMEM173
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Comments for STING / TMEM173
TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family.
Protein type: Apoptosis; Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass; Mitochondrial
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: cytoplasmic vesicle membrane; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: activation of innate immune response; apoptosis; defense response to virus; innate immune response; interferon-beta production; positive regulation of defense response to virus by host; positive regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of interferon type I production
Disease: Sting-associated Vasculopathy, Infantile-onset
Research Articles on STING / TMEM173
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Pathways associated with anti-STING / TMEM173 antibody
Diseases associated with anti-STING / TMEM173 antibody
Organs/Tissues associated with anti-STING / TMEM173 antibody
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