NP_056505.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
141,737 Da
NCBI Official Full Name
serine/threonine kinase 36
NCBI Official Synonym Full Names
serine/threonine kinase 36
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase 36
UniProt Protein Name
Serine/threonine-protein kinase 36
UniProt Synonym Protein Names
Fused homolog
UniProt Entry Name
STK36_HUMAN
NCBI Summary for STK36
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Comments for STK36
Fused: a serine/threonine protein kinase of the ULK family. Plays a role in Hedgehog (Hh) signaling. Interacts with Smoothened (Smo), the receptor for Hedgehog (Hh). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of Fused to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Two alternatively spliced isoforms have been described.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; Other group; ULK family
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity; transcription factor binding
Biological Process: activation of hh target transcription factor; brain development; cilium biogenesis; positive regulation of smoothened signaling pathway; post-embryonic development; protein amino acid phosphorylation; regulation of transcription factor activity
Research Articles on STK36
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Products associated with anti-STK36 antibody
Pathways associated with anti-STK36 antibody
Diseases associated with anti-STK36 antibody
Organs/Tissues associated with anti-STK36 antibody
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