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anti-STK4 antibody :: Rabbit STK4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9127929
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STK4, Polyclonal Antibody

★Popular Item★
 Also Known As   

STK4 Polyclonal Antibody

 Product Gene Name   

anti-STK4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604965
 3D Structure    ModBase 3D Structure for Q13043
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human STK4
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-STK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STK4 antibody

   The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
 Applications Tested/Suitable for anti-STK4 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

 Application Notes for anti-STK4 antibody    WB 1:500 - 1:2000
IHC 1:20 - 1:200
IF 1:20 - 1:100
IP 1:20 - 1:50
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 Western Blot (WB) of anti-STK4 antibody    Western blot analysis of extracts of various cell lines, using STK4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 15s.
anti-STK4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-STK4 antibody    Immunohistochemistry of paraffin-embedded human stomach using STK4 antibody at dilution of 1:100 (40x lens).
anti-STK4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-STK4 antibody    Immunohistochemistry of paraffin-embedded human esophagus using STK4 antibody at dilution of 1:100 (40x lens).
anti-STK4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunoprecipitation (IP) of anti-STK4 antibody    Immunoprecipitation analysis of 100ug extracts of HepG2 cells using 3ug STK4 antibody. Western blot was performed from the immunoprecipitate using STK4 antibody at a dilition of 1:1000.
anti-STK4 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for STK4. It may not necessarily be applicable to this product.
 NCBI GI #    5454096
 NCBI GeneID    6789
 NCBI Accession #    NP_006273.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006282.2 [Other Products]
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 UniProt Primary Accession #    Q13043 [Other Products]
 UniProt Secondary Accession #    Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4; B2RCR8 [Other Products]
 UniProt Related Accession #    Q13043 [Other Products]
 Molecular Weight    56kDa
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 NCBI Official Full Name    serine/threonine-protein kinase 4
 NCBI Official Synonym Full Names    serine/threonine kinase 4
 NCBI Official Symbol    STK4 [Similar Products]
 NCBI Official Synonym Symbols   
KRS2; MST1; YSK3; TIIAC
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase 4
 UniProt Protein Name    Serine/threonine-protein kinase 4
 UniProt Synonym Protein Names   
Mammalian STE20-like protein kinase 1; MST-1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    STK4 [Similar Products]
 UniProt Synonym Gene Names    KRS2; MST1; MST-1; MST1/N; MST1/C [Similar Products]
 UniProt Entry Name    STK4_HUMAN
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 NCBI Summary for STK4    The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STK4    MST1: a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage.

Protein type: Autophagy; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; MST subfamily

Chromosomal Location of Human Ortholog: 20q11.2-q13.2

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein dimerization activity; identical protein binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; magnesium ion binding; transcription factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: central nervous system development; positive regulation of protein binding; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; cell morphogenesis; negative regulation of organ growth; signal transduction; protein amino acid phosphorylation; patterning of blood vessels; keratinocyte differentiation; negative regulation of cell proliferation; peptidyl-serine phosphorylation; positive regulation of fat cell differentiation; neural tube formation

Disease: T-cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations
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 Research Articles on STK4    1. Genetic inactivation of STK4 restores YAP1 levels, triggering cell death in hematologic malignancies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STK4 antibodyPathways associated with anti-STK4 antibody
 Reference Product  PubMed Publications
 MST1 antibody  >104 publications with STK4 and MST1
 STK3 antibody  >33 publications with STK4 and STK3
 LATS1 antibody  >16 publications with STK4 and LATS1
 RASSF1 antibody  >16 publications with STK4 and RASSF1
 SAV1 antibody  >9 publications with STK4 and SAV1
 MOB1B antibody  >5 publications with STK4 and MOB1B
 RASSF2 antibody  >2 publications with STK4 and RASSF2
 RASSF3 antibody  >1 publications with STK4 and RASSF3
 RASSF4 antibody  >1 publications with STK4 and RASSF4
 Products by Pathway  Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram
Diseases associated with anti-STK4 antibodyOrgans/Tissues associated with anti-STK4 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >9 publications with STK4 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >7 publications with STK4 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >6 publications with STK4 and Carcinoma, Hepatocellular
 Prostatic Neoplasms Antibodies  >6 publications with STK4 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >6 publications with STK4 and Adenocarcinoma
 Liver Diseases Antibodies  >5 publications with STK4 and Liver Diseases
 Lymphoma Antibodies  >5 publications with STK4 and Lymphoma
 Liver Neoplasms Antibodies  >5 publications with STK4 and Liver Neoplasms
 Skin Diseases Antibodies  >5 publications with STK4 and Skin Diseases
 Lung Neoplasms Antibodies  >5 publications with STK4 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with STK4 and Blood
 Muscle Antibodies  >12 publications with STK4 and Muscle
 Lung Antibodies  >9 publications with STK4 and Lung
 Liver Antibodies  >8 publications with STK4 and Liver
 Prostate Antibodies  >8 publications with STK4 and Prostate
 Bone Antibodies  >7 publications with STK4 and Bone
 Pancreas Antibodies  >4 publications with STK4 and Pancreas
 Bone Marrow Antibodies  >3 publications with STK4 and Bone Marrow
 Connective Tissue Antibodies  >3 publications with STK4 and Connective Tissue
 Vascular Antibodies  >3 publications with STK4 and Vascular
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