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anti-STRA6 antibody :: Goat STRA6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421539
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STRA6, Polyclonal Antibody

 Also Known As   

Goat anti-STRA6 (mouse, rat) Antibody

 Product Synonym Names    STRA6; stimulated by retinoic acid gene 6 homolog (mouse); FLJ12541; MCOPS9; PP14296; stimulated by retinoic acid gene 6 homolog; STRA6 antibody; stimulated by retinoic acid gene 6 homolog (mouse) antibody; FLJ12541 antibody; MCOPS9 antibody; PP14296 antibody; stimulated by retinoic acid gene 6 homolog antibody; STRA6 (mouse, rat)
 Product Gene Name   

anti-STRA6 antibody

[Similar Products]
 Antibody/Peptide Pairs    STRA6 peptide (MBS426933) is used for blocking the activity of STRA6 antibody (MBS421539)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QAFRKAALTS AKAN
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QAFRKAALTSAKAN, from the C Terminus of the protein sequence according to NP_033317.1; NP_001025095.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-STRA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-STRA6 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-STRA6 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 90kDa band observed in lysates of 3T3-L1 adipocytes that is reduced by stra6 siRNA. The 90kDa band is stained after retrovirally overexpressing Mouse Stra6 and not after overexpressing Human Stra6 in 3T3 preadipocytes (calculated MW of 73.8kDa according to NP_001025095.1). Please note a non-specific band of ~80kDa. Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-STRA6 antibody    Staining of 3T3-L1 lysates (35ug protein in RIPA buffer). Primary incubation was 3 hour. Detected by chemiluminescence.
anti-STRA6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for STRA6. It may not necessarily be applicable to this product.
 NCBI GI #    6678171
 NCBI GeneID    20897
 NCBI Accession #    NP_033317.1 [Other Products]
 NCBI Related Accession #    NP_001025095.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009291.1 [Other Products]
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 UniProt Secondary Accession #    Q6DIA8 [Other Products]
 UniProt Related Accession #    O70491 [Other Products]
 Molecular Weight    73,775 Da
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 NCBI Official Full Name    stimulated by retinoic acid gene 6
 NCBI Official Synonym Full Names    stimulated by retinoic acid gene 6
 NCBI Official Symbol    Stra6 [Similar Products]
 NCBI Official Synonym Symbols   
AI891933
[Similar Products]
 NCBI Protein Information    stimulated by retinoic acid gene 6 protein
 UniProt Protein Name    Stimulated by retinoic acid gene 6 protein
 UniProt Synonym Protein Names   
Retinoic acid-responsive protein
 Protein Family    Stimulated by retinoic acid gene 6 protein
 UniProt Gene Name    Stra6 [Similar Products]
 UniProt Entry Name    STRA6_MOUSE
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 UniProt Comments for STRA6    STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane; membrane; plasma membrane; protein complex

Molecular Function: protein binding; receptor activity; vitamin transporter activity

Biological Process: adrenal gland development; alveolus development; artery morphogenesis; blood vessel development; cognition; developmental growth; digestive tract morphogenesis; ear development; embryonic gut development; feeding behavior; female genitalia development; heart development; kidney development; learning; lung development; neuromuscular process; nose morphogenesis; positive regulation of behavior; positive regulation of JAK-STAT cascade; smooth muscle development; transport; vocal learning
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 Research Articles on STRA6    1. Studies indicate that STRA6 is indeed a bona fide vitamin A transporter and provide novel insights into the regulatory mechanism that governs vitamin A homeostasis in peripheral tissues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-STRA6 antibodyDiseases associated with anti-STRA6 antibody
 Products by Pathway  Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Disease Name  Pubmed Publications
 Anophthalmos Antibodies  >12 publications with STRA6 and Anophthalmos
 Microphthalmos Antibodies  >10 publications with STRA6 and Microphthalmos
 Anophthalmia with pulmonary hypoplasia Antibodies  >8 publications with STRA6 and Anophthalmia with pulmonary hypoplasia
 Hernia, Diaphragmatic Antibodies  >7 publications with STRA6 and Hernia, Diaphragmatic
 Cardiovascular Abnormalities Antibodies  >5 publications with STRA6 and Cardiovascular Abnormalities
 Lung Diseases Antibodies  >4 publications with STRA6 and Lung Diseases
 Inflammation Antibodies  >4 publications with STRA6 and Inflammation
 Intellectual Disability Antibodies  >3 publications with STRA6 and Intellectual Disability
 Heart Defects, Congenital Antibodies  >3 publications with STRA6 and Heart Defects, Congenital
 Infertility, Female Antibodies  >2 publications with STRA6 and Infertility, Female
Organs/Tissues associated with anti-STRA6 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >35 publications with STRA6 and Eye
 Brain Antibodies  >18 publications with STRA6 and Brain
 Lung Antibodies  >14 publications with STRA6 and Lung
 Embryonic Tissue Antibodies  >10 publications with STRA6 and Embryonic Tissue
 Skin Antibodies  >6 publications with STRA6 and Skin
 Kidney Antibodies  >3 publications with STRA6 and Kidney
 Spleen Antibodies  >3 publications with STRA6 and Spleen
 Extraembryonic Tissue Antibodies  >2 publications with STRA6 and Extraembryonic Tissue
 Joint Antibodies  >1 publications with STRA6 and Joint
 Mammary Gland Antibodies  >1 publications with STRA6 and Mammary Gland
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