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anti-STRADA antibody :: Rabbit anti-Human, Rat STRADA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045576
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STRADA, Polyclonal Antibody

★Popular Item★
 Also Known As   

STRADA Antibody

 Product Synonym Names    STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96; STRADA; LYK5
 Product Gene Name   

anti-STRADA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608626
 3D Structure    ModBase 3D Structure for Q7RTN6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human STE20-related kinase adapter protein alpha protein (25-210AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-55052 / sc-34102 / sc-34103 / sc-130882 / sc-99155
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-STRADA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STRADA antibody

   Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
 Applications Tested/Suitable for anti-STRADA antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-STRADA antibody    Western blot
All lanes: STRADA antibody IgG at 1.98ug/ml+ Rat heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49,39,44,34,42,35 kDa
Observed band size: 48 kDa

anti-STRADA antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-STRADA antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7045576 at dilution 1:100
anti-STRADA antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-STRADA antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045576 at dilution 1:100
anti-STRADA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for STRADA. It may not necessarily be applicable to this product.
 NCBI GI #    51242960
 NCBI GeneID    92335
 NCBI Accession #    NP_001003786.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003786.2 [Other Products]
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 UniProt Primary Accession #    Q7RTN6 [Other Products]
 UniProt Secondary Accession #    Q5JPI2; Q7Z4K9; Q8NC31; Q8NCF1; Q9H272; B4DDE3; B4DW17; J3KTC9 [Other Products]
 UniProt Related Accession #    Q7RTN6 [Other Products]
 Molecular Weight    34,625 Da
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 NCBI Official Full Name    STE20-related kinase adapter protein alpha isoform 2
 NCBI Official Synonym Full Names    STE20-related kinase adaptor alpha
 NCBI Official Symbol    STRADA [Similar Products]
 NCBI Official Synonym Symbols   
LYK5; PMSE; Stlk; STRAD; NY-BR-96
[Similar Products]
 NCBI Protein Information    STE20-related kinase adapter protein alpha
 UniProt Protein Name    STE20-related kinase adapter protein alpha
 UniProt Synonym Protein Names   
STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96
 Protein Family    STE20-related kinase adapter protein
 UniProt Gene Name    STRADA [Similar Products]
 UniProt Synonym Gene Names    ; STRAD alpha [Similar Products]
 UniProt Entry Name    STRAA_HUMAN
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 NCBI Summary for STRADA    The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
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 UniProt Comments for STRADA    STRAD: a pseudokinase which, in complex with CAB39, binds to and activates LKB1. Relocates LKB1 from the nucleus to the cytoplasm. Plays an essential role in LKB1-mediated G1 cell cycle arrest. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Motility/polarity/chemotaxis; STE group; STE20 family; STLK subfamily

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: kinase binding; protein binding; protein kinase activator activity; protein kinase activity; protein serine/threonine kinase activator activity

Biological Process: activation of protein kinase activity; cell cycle arrest; protein amino acid phosphorylation; protein export from nucleus

Disease: Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
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 Research Articles on STRADA    1. aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STRADA antibodyPathways associated with anti-STRADA antibody
 Reference Product  PubMed Publications
 STK11 antibody  >1 publications with STRADA and STK11
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
Diseases associated with anti-STRADA antibodyOrgans/Tissues associated with anti-STRADA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >212 publications with STRADA and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >135 publications with STRADA and Cardiovascular Diseases
 Vascular Diseases Antibodies  >114 publications with STRADA and Vascular Diseases
 Inflammation Antibodies  >78 publications with STRADA and Inflammation
 Liver Diseases Antibodies  >53 publications with STRADA and Liver Diseases
 Disease Models, Animal Antibodies  >49 publications with STRADA and Disease Models, Animal
 Necrosis Antibodies  >39 publications with STRADA and Necrosis
 Neoplasm Metastasis Antibodies  >34 publications with STRADA and Neoplasm Metastasis
 Fibrosis Antibodies  >31 publications with STRADA and Fibrosis
 Liver Neoplasms Antibodies  >31 publications with STRADA and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >332 publications with STRADA and Blood
 Brain Antibodies  >214 publications with STRADA and Brain
 Liver Antibodies  >138 publications with STRADA and Liver
 Vascular Antibodies  >124 publications with STRADA and Vascular
 Muscle Antibodies  >107 publications with STRADA and Muscle
 Kidney Antibodies  >104 publications with STRADA and Kidney
 Bone Antibodies  >91 publications with STRADA and Bone
 Heart Antibodies  >72 publications with STRADA and Heart
 Lung Antibodies  >70 publications with STRADA and Lung
 Nerve Antibodies  >60 publications with STRADA and Nerve
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