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anti-UBASH3A antibody :: Goat STS2/TULA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420681
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STS2/TULA (UBASH3A), Polyclonal Antibody

 Also Known As   

Goat anti-STS2/TULA (internal) Antibody

 Product Synonym Names    Goat Anti-STS2 / TULA (N Terminus) Antibody; TULA; STS2 CBL-interacting protein 4; UBASH3A; ubiquitin associated and SH3 domain containing, A; T-cell ubiquitin ligand protein; Suppressor of T-cell receptor signaling 2; CLIP4; TULA antibody; STS2 CBL-interacting protein 4 antibody; UBASH3A antibody; ubiquitin associated and SH3 domain containing; A antibody; T-cell ubiquitin ligand protein antibody; Suppressor of T-cell receptor signaling 2 antibody; CLIP4 antibody; STS2 / TULA (internal)
 Product Gene Name   

anti-UBASH3A antibody

[Similar Products]
 Product Synonym Gene Name    STS2; TULA [Similar Products]
 Antibody/Peptide Pairs    STS2 / TULA peptide (MBS428029) is used for blocking the activity of STS2/TULA antibody (MBS420681)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QQCSTPDGKY YRPD
 OMIM    605736
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence QQCSTPDGKYYRPD, from the internal region of the protein sequence according to NP_061834.1; NP_001001895.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_061834.1 and NP_001001895.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-UBASH3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UBASH3A antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-UBASH3A antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Spleen shows cytoplasm staining of T-cells eccentrically gathered around an artery. Recommended concentration, 2.5ug/ml.
Western Blot: Preliminary experiments gave an approx 48kDa band in lysates of B-cell line Daudi after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 74.1kDa according to NP_061834.1 and 69.8kDa according to NP_001001895.1. The 48kDa band was successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-UBASH3A antibody    (2.5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-UBASH3A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for UBASH3A. It may not necessarily be applicable to this product.
 NCBI GI #    9507221
 NCBI GeneID    53347
 NCBI Accession #    NP_061834.1 [Other Products]
 NCBI Related Accession #    NP_001001895.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018961.3 [Other Products]
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 UniProt Secondary Accession #    Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9; G5E9E4 [Other Products]
 UniProt Related Accession #    P57075 [Other Products]
 Molecular Weight    59,167 Da
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 NCBI Official Full Name    ubiquitin-associated and SH3 domain-containing protein A isoform 1
 NCBI Official Synonym Full Names    ubiquitin associated and SH3 domain containing A
 NCBI Official Symbol    UBASH3A [Similar Products]
 NCBI Official Synonym Symbols   
TULA; CLIP4; STS-2; TULA-1
[Similar Products]
 NCBI Protein Information    ubiquitin-associated and SH3 domain-containing protein A
 UniProt Protein Name    Ubiquitin-associated and SH3 domain-containing protein A
 UniProt Synonym Protein Names   
Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1
 Protein Family    Ubiquitin-associated and SH3 domain-containing protein
 UniProt Gene Name    UBASH3A [Similar Products]
 UniProt Synonym Gene Names    STS2; CLIP4; STS-2; TULA-1 [Similar Products]
 UniProt Entry Name    UBS3A_HUMAN
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 NCBI Summary for UBASH3A    This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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 UniProt Comments for UBASH3A    STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytosol; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of T cell receptor signaling pathway; regulation of cytokine production
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 Research Articles on UBASH3A    1. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-UBASH3A antibodyOrgans/Tissues associated with anti-UBASH3A antibody
 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >4 publications with UBASH3A and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >3 publications with UBASH3A and Inflammation
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies  >1 publications with UBASH3A and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with UBASH3A and Abnormalities, Multiple
 Nephritis Antibodies  >1 publications with UBASH3A and Nephritis
 Nervous System Diseases Antibodies  >1 publications with UBASH3A and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with UBASH3A and Blood
 Thyroid Antibodies  >2 publications with UBASH3A and Thyroid
 Spleen Antibodies  >1 publications with UBASH3A and Spleen
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