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anti-STT3A antibody :: Rabbit STT3, subunit of the oligosaccharyltransferase complex, homolog A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714262 anti-STT3A antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STT3, subunit of the oligosaccharyltransferase complex, homolog A (STT3A), Polyclonal Antibody

 Also Known As   

Rabbit anti-human STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) polyclonal Antibody

 Product Synonym Names    STT3; subunit of the oligosaccharyltransferase complex; homolog A (S. cerevisiae); STT3A; FLJ27038; ITM1; MGC9042; STT3-A; TMC
 Product Gene Name   

anti-STT3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615596
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human STT3A
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-168218
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-STT3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-STT3A antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for STT3A. It may not necessarily be applicable to this product.
 NCBI GI #    127799903
 NCBI GeneID    3703
 NCBI Accession #    AAH48348.2 [Other Products]
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 UniProt Secondary Accession #    Q86XU9; Q8TE35; Q8WUB4; B4DJ24; E9PNQ1 [Other Products]
 UniProt Related Accession #    P46977 [Other Products]
 Molecular Weight    69,589 Da [Similar Products]
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 NCBI Official Full Name    STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
 NCBI Official Synonym Full Names    STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
 NCBI Official Symbol    STT3A [Similar Products]
 NCBI Official Synonym Symbols   
TMC; ITM1; STT3-A
[Similar Products]
 NCBI Protein Information    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; B5; transmembrane conserved; transmembrane protein TMC; integral membrane protein 1; integral transmembrane protein 1; oligosaccharyl transferase subunit STT3A; dolichyl-diphosphooligosaccharide protein glycotransferase; STT3A, cataylic subunit of the oligosaccharyltransferase complex; STT3, subunit of the oligosaccharyltransferase complex, homolog A
 UniProt Protein Name    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
 UniProt Synonym Protein Names   
B5; Integral membrane protein 1; Transmembrane protein TMC
 Protein Family    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase
 UniProt Gene Name    STT3A [Similar Products]
 UniProt Synonym Gene Names    ITM1; TMC; Oligosaccharyl transferase subunit STT3A; STT3-A [Similar Products]
 UniProt Entry Name    STT3A_HUMAN
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 NCBI Summary for STT3A    The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
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 UniProt Comments for STT3A    ITM1: Catalytic component of oligosaccharyltransferase (OST) oligosaccharyltransferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. Belongs to the STT3 family.

Protein type: Membrane protein, integral; Transferase; EC 2.4.99.18; Membrane protein, multi-pass; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: endoplasmic reticulum membrane; membrane; oligosaccharyl transferase complex; integral to membrane

Molecular Function: protein binding; dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Biological Process: cellular protein metabolic process; co-translational protein modification; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

Disease: Congenital Disorder Of Glycosylation, Type Iw
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 Research Articles on STT3A    1. Consensus sites containing large hydrophobic and negatively charged middle residues are frequently skipped by STT3A during protein translation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STT3A antibodyPathways associated with anti-STT3A antibody
 Reference Product  PubMed Publications
 DAD1 antibody  >2 publications with STT3A and DAD1
 MAGT1 antibody  >1 publications with STT3A and MAGT1
 RPN2 antibody  >1 publications with STT3A and RPN2
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycosylation By Oligosaccharyltransferase Pathway antibodies  N-glycosylation By Oligosaccharyltransferase Pathway Diagram
 N-glycosylation By Oligosaccharyltransferase Pathway antibodies  N-glycosylation By Oligosaccharyltransferase Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-STT3A antibodyOrgans/Tissues associated with anti-STT3A antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with STT3A and Congenital Abnormalities
 Immune System Diseases Antibodies  >1 publications with STT3A and Immune System Diseases
 Fatty Liver Antibodies  >1 publications with STT3A and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >6 publications with STT3A and Thyroid
 Tonsil Antibodies  >1 publications with STT3A and Tonsil
 Ovary Antibodies  >1 publications with STT3A and Ovary
 Testis Antibodies  >1 publications with STT3A and Testis
 Liver Antibodies  >1 publications with STT3A and Liver
 Brain Antibodies  >1 publications with STT3A and Brain
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