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anti-STUB1 antibody :: Goat STUB1/CHIP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420984
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STUB1/CHIP, Polyclonal Antibody

 Also Known As   

Goat anti-STUB1/CHIP Antibody

 Product Synonym Names    STUB1; CHIP; STIP1 homology and U-Box containing protein 1; HSPABP2; NY-CO-7; SDCCAG7; serologically defined colon cancer antigen 7; carboxy terminus of Hsp70p-interacting protein; heat shock protein A binding protein 2 (c-terminal); LA16c-313D11. 6; UBOX1; STUB1 antibody; CHIP antibody; STIP1 homology and U-Box containing protein 1 antibody; HSPABP2 antibody; NY-CO-7 antibody; SDCCAG7 antibody; serologically defined colon cancer antigen 7 antibody; carboxy terminus of Hsp70p-interacting protein antibody; heat shock protein A binding protein 2 (c-terminal) antibody; LA16c-313D11. 6 antibody; UBOX1 antibody; STUB1 / CHIP
 Product Gene Name   

anti-STUB1 antibody

[Similar Products]
 Product Synonym Gene Name    CHIP [Similar Products]
 Antibody/Peptide Pairs    STUB1 / CHIP peptide (MBS426700) is used for blocking the activity of STUB1/CHIP antibody (MBS420984)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DAFISENGWV EDY
 OMIM    607207
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DAFISENGWVEDY, from the C Terminus of the protein sequence according to NP_005852.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-STUB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-STUB1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-STUB1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 35kDa band observed in Human Muscle lysates (calculated MW of 34.9kDa according to NP_005852.2). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-STUB1 antibody    Staining (0.3ug/ml) of Human Muscle lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-STUB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for STUB1. It may not necessarily be applicable to this product.
 NCBI GI #    56181387
 NCBI GeneID    10273
 NCBI Accession #    NP_005852.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005861.3 [Other Products]
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 UniProt Secondary Accession #    O60526; Q969U2; Q9HBT1; A2IDB9 [Other Products]
 UniProt Related Accession #    Q9UNE7 [Other Products]
 Molecular Weight    27,067 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase CHIP isoform a
 NCBI Official Synonym Full Names    STIP1 homology and U-box containing protein 1
 NCBI Official Symbol    STUB1 [Similar Products]
 NCBI Official Synonym Symbols   
CHIP; UBOX1; SCAR16; HSPABP2; NY-CO-7; SDCCAG7
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase CHIP
 UniProt Protein Name    E3 ubiquitin-protein ligase CHIP
 UniProt Synonym Protein Names   
Antigen NY-CO-7
 Protein Family    STIP1 homology and U box-containing protein
 UniProt Gene Name    STUB1 [Similar Products]
 UniProt Entry Name    CHIP_HUMAN
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 NCBI Summary for STUB1    This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]
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 UniProt Comments for STUB1    CHIP: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Homodimer. Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DYX1C1 and POLB. Interacts (via TPR repeats) with HSP90AA1. Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W. Interacts (via the U-box domain) with the UBE2V2- UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with DNAJB6. Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.19; Adaptor/scaffold; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; intermediate filament cytoskeleton; nuclear inclusion body; nucleoplasm; plasma membrane; ubiquitin conjugating enzyme complex; ubiquitin ligase complex; Z disc

Molecular Function: enzyme binding; G-protein-coupled receptor binding; Hsp70 protein binding; Hsp90 protein binding; kinase binding; ligase activity; misfolded protein binding; protein binding; protein binding, bridging; protein homodimerization activity; SMAD binding; TPR domain binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: DNA repair; misfolded or incompletely synthesized protein catabolic process; negative regulation of protein binding; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein maturation; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of glucocorticoid metabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process; unfolded protein response

Disease: Spinocerebellar Ataxia, Autosomal Recessive 16
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 Research Articles on STUB1    1. Data suggest that CHIP plays roles in the regulation of autophagic flux.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STUB1 antibodyPathways associated with anti-STUB1 antibody
 Reference Product  PubMed Publications
 HSPA8 antibody  >27 publications with STUB1 and HSPA8
 UBE2D1 antibody  >6 publications with STUB1 and UBE2D1
 MAPT antibody  >4 publications with STUB1 and MAPT
 UBE2D2 antibody  >4 publications with STUB1 and UBE2D2
 TP53 antibody  >3 publications with STUB1 and TP53
 UBE2N antibody  >2 publications with STUB1 and UBE2N
 UBE2D3 antibody  >1 publications with STUB1 and UBE2D3
 UBC antibody  >1 publications with STUB1 and UBC
 HSP90AA1 antibody  >1 publications with STUB1 and HSP90AA1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-STUB1 antibodyOrgans/Tissues associated with anti-STUB1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >46 publications with STUB1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >17 publications with STUB1 and Breast Neoplasms
 Fibrosis Antibodies  >12 publications with STUB1 and Fibrosis
 Disease Models, Animal Antibodies  >12 publications with STUB1 and Disease Models, Animal
 Inflammation Antibodies  >8 publications with STUB1 and Inflammation
 Atrophy Antibodies  >4 publications with STUB1 and Atrophy
 Prostatic Neoplasms Antibodies  >4 publications with STUB1 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >4 publications with STUB1 and Prostatic Diseases
 Adenocarcinoma Antibodies  >4 publications with STUB1 and Adenocarcinoma
 Necrosis Antibodies  >3 publications with STUB1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with STUB1 and Brain
 Blood Antibodies  >10 publications with STUB1 and Blood
 Lung Antibodies  >9 publications with STUB1 and Lung
 Nerve Antibodies  >9 publications with STUB1 and Nerve
 Kidney Antibodies  >7 publications with STUB1 and Kidney
 Muscle Antibodies  >6 publications with STUB1 and Muscle
 Prostate Antibodies  >5 publications with STUB1 and Prostate
 Bone Antibodies  >5 publications with STUB1 and Bone
 Liver Antibodies  >4 publications with STUB1 and Liver
 Heart Antibodies  >4 publications with STUB1 and Heart
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