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anti-STX2 antibody :: Rabbit STX2 / Syntaxin 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242500
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STX2 / Syntaxin 2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Rat STX2 / Syntaxin 2

 Product Synonym Names    Anti-STX2 / Syntaxin 2 Antibody (aa1-19) IHC-plus; STX2; Epimorphin; EPM; EPIM; STX2B; Syntaxin-2; Stx2A; STX2C; Syntaxin 2; Rat STX2; Syntaxin 2
 Product Gene Name   

anti-STX2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    132350
 3D Structure    ModBase 3D Structure for P32856
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine, Chicken, Drosophila, Xenopus, Hamster, Human, Insect, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
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 Specificity    Detects an ~35 kD protein, corresponding to the apparent molecular mass of syntaxin 2 on SDSPAGE immunoblots, in samples from human, mouse, rat, bovine, canine, chicken, Drosophila, hamster, insect, monkey, pig, rabbit, sheep and Xenopus origins. The antibody specificity has been confirmed by specific peptide inhibition in immunoblotting studies.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, pH 7.2, 0.09% azide 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Rat
 Immunogen Description    Rat syntaxin 2 synthetic peptide, corresponding to amino acid residues 1-19, conjugated to KLH.
 Immunogen Type    Synthetic peptide - KLH conjugated
 Immunogen    STX2 / Syntaxin 2 antibody was raised against rat syntaxin 2 synthetic peptide, corresponding to amino acid residues 1-19, conjugated to KLH.
 Antigen Modification    aa1-19
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
 Other Notes    Small volumes of anti-STX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STX2 antibody

   The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.
 Product Categories/Family for anti-STX2 antibody    Family: Syntaxin/epimorphin
 Applications Tested/Suitable for anti-STX2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-STX2 antibody    IHC-P (10 ug/ml), IP (10 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-STX2 antibody    Anti-STX2 / Syntaxin 2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-STX2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for STX2. It may not necessarily be applicable to this product.
 NCBI GI #    37577287
 NCBI GeneID    2054
 NCBI Accession #    NP_001971.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001980.3 [Other Products]
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 UniProt Primary Accession #    P32856 [Other Products]
 UniProt Secondary Accession #    Q86VW8 [Other Products]
 UniProt Related Accession #    P32856 [Other Products]
 Molecular Weight    32,425 Da
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 NCBI Official Full Name    syntaxin-2 isoform 1
 NCBI Official Synonym Full Names    syntaxin 2
 NCBI Official Symbol    STX2 [Similar Products]
 NCBI Official Synonym Symbols   
EPM; EPIM; STX2A; STX2B; STX2C
[Similar Products]
 NCBI Protein Information    syntaxin-2; epimorphin
 UniProt Protein Name    Syntaxin-2
 UniProt Synonym Protein Names   
Epimorphin
 Protein Family    Syntaxin
 UniProt Gene Name    STX2 [Similar Products]
 UniProt Synonym Gene Names    EPIM; STX2A; STX2B; STX2C [Similar Products]
 UniProt Entry Name    STX2_HUMAN
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 NCBI Summary for STX2    The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STX2    STX2: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: SNARE complex; extracellular space; synaptic vesicle; cell surface; intracellular membrane-bound organelle; lamellipodium; basolateral plasma membrane; integral to membrane; plasma membrane; endomembrane system; intercellular junction; lipid raft

Molecular Function: protein dimerization activity; SNAP receptor activity; SNARE binding; protein binding; calcium-dependent protein binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; organ morphogenesis; vesicle docking; response to hydroperoxide; regulation of blood coagulation; acrosome reaction; ectoderm development; cell differentiation; signal transduction; protein oligomerization; regulation of cytoskeleton organization and biogenesis
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 Research Articles on STX2    1. Identify 3 loci associated with circulating tPA levels, the PLAT region, STXBP5, and STX2. Functional studies implicate a novel role for STXBP5 and STX2 in regulating tPA release.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STX2 antibodyPathways associated with anti-STX2 antibody
 Reference Product  PubMed Publications
 VAMP8 antibody  >1 publications with STX2 and VAMP8
 VAMP2 antibody  >1 publications with STX2 and VAMP2
 SNAP23 antibody  >1 publications with STX2 and SNAP23
 Products by Pathway  Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
Diseases associated with anti-STX2 antibodyOrgans/Tissues associated with anti-STX2 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >139 publications with STX2 and Kidney Diseases
 Disease Models, Animal Antibodies  >57 publications with STX2 and Disease Models, Animal
 Necrosis Antibodies  >28 publications with STX2 and Necrosis
 Inflammation Antibodies  >21 publications with STX2 and Inflammation
 Hemorrhage Antibodies  >13 publications with STX2 and Hemorrhage
 Cardiovascular Diseases Antibodies  >13 publications with STX2 and Cardiovascular Diseases
 Weight Loss Antibodies  >9 publications with STX2 and Weight Loss
 Hemolysis Antibodies  >7 publications with STX2 and Hemolysis
 Heart Diseases Antibodies  >5 publications with STX2 and Heart Diseases
 Fibrosis Antibodies  >4 publications with STX2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >128 publications with STX2 and Blood
 Kidney Antibodies  >84 publications with STX2 and Kidney
 Intestine Antibodies  >77 publications with STX2 and Intestine
 Brain Antibodies  >35 publications with STX2 and Brain
 Lung Antibodies  >13 publications with STX2 and Lung
 Liver Antibodies  >13 publications with STX2 and Liver
 Nerve Antibodies  >9 publications with STX2 and Nerve
 Heart Antibodies  >8 publications with STX2 and Heart
 Embryonic Tissue Antibodies  >7 publications with STX2 and Embryonic Tissue
 Muscle Antibodies  >6 publications with STX2 and Muscle
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