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anti-SUMF1 antibody :: Goat SUMF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421893
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SUMF1, Polyclonal Antibody

 Also Known As   

Goat anti-SUMF1 Antibody

 Product Synonym Names    SUMF1; sulfatase modifying factor 1; AAPA3037; FGE; MGC131853; MGC150436; C-alpha-formylglycine-generating enzyme; OTTHUMP00000115300; SUMF1 antibody; sulfatase modifying factor 1 antibody; AAPA3037 antibody; FGE antibody; MGC131853 antibody; MGC150436 antibody; C-alpha-formylglycine-generating enzyme antibody; OTTHUMP00000115300 antibody
 Product Gene Name   

anti-SUMF1 antibody

[Similar Products]
 Antibody/Peptide Pairs    SUMF1 peptide (MBS426423) is used for blocking the activity of SUMF1 antibody (MBS421893)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ETLNPKGPPS GKDR
 OMIM    272200
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ETLNPKGPPSGKDR, from the internal region of the protein sequence according to NP_877437.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SUMF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SUMF1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SUMF1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 37-40kDa band observed in Mouse Pancreas, Mouse Eye and Human Kidney lysates (calculated MW of 40.6kDa according to Human NP_877437.2 and 40.6kDa according to Mouse NP_666049.2). Recommended concentration: 0.5-2ug/ml.
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 Western Blot (WB) of anti-SUMF1 antibody    (1ug/ml) staining of Mouse Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SUMF1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SUMF1. It may not necessarily be applicable to this product.
 NCBI GI #    38202250
 NCBI GeneID    285362
 NCBI Accession #    NP_877437.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_182760.3 [Other Products]
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 UniProt Secondary Accession #    Q0VAC6; Q0VAC7; Q2NL78; Q53ZE4; Q6UY39; Q96AK5; Q96DK8; B4DXK5; B7XD05; E9PGL0; G5E9B0 [Other Products]
 UniProt Related Accession #    Q8NBK3 [Other Products]
 Molecular Weight    38,386 Da
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 NCBI Official Full Name    sulfatase-modifying factor 1 isoform 1
 NCBI Official Synonym Full Names    sulfatase modifying factor 1
 NCBI Official Symbol    SUMF1 [Similar Products]
 NCBI Official Synonym Symbols   
FGE; UNQ3037; AAPA3037
[Similar Products]
 NCBI Protein Information    sulfatase-modifying factor 1
 UniProt Protein Name    Sulfatase-modifying factor 1
 UniProt Synonym Protein Names   
C-alpha-formylglycine-generating enzyme 1
 Protein Family    Sulfatase-modifying factor
 UniProt Gene Name    SUMF1 [Similar Products]
 UniProt Synonym Gene Names    FGE [Similar Products]
 UniProt Entry Name    SUMF1_HUMAN
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 NCBI Summary for SUMF1    This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
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 UniProt Comments for SUMF1    SUMF1: Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE. Defects in SUMF1 are the cause of multiple sulfatase deficiency (MSD). MSD is a clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay. Inheritance is autosomal recessive. Belongs to the sulfatase-modifying factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Endoplasmic reticulum; EC 1.8.99.-; Oxidoreductase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p26.1

Cellular Component: endoplasmic reticulum lumen

Molecular Function: metal ion binding; oxidoreductase activity; protein homodimerization activity

Biological Process: glycosphingolipid metabolic process; post-translational protein modification

Disease: Multiple Sulfatase Deficiency
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 Research Articles on SUMF1    1. SUMF1 catalyses a monooxygenase type of reaction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SUMF1 antibodyDiseases associated with anti-SUMF1 antibody
 Products by Pathway  Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 The Activation Of Arylsulfatases Pathway antibodies  The Activation Of Arylsulfatases Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >35 publications with SUMF1 and Nervous System Diseases
 Brain Diseases Antibodies  >31 publications with SUMF1 and Brain Diseases
 Multiple Sulfatase Deficiency Disease Antibodies  >24 publications with SUMF1 and Multiple Sulfatase Deficiency Disease
 Ataxia Antibodies  >7 publications with SUMF1 and Ataxia
 Disease Models, Animal Antibodies  >7 publications with SUMF1 and Disease Models, Animal
 Mental Disorders Antibodies  >7 publications with SUMF1 and Mental Disorders
 Neurobehavioral Manifestations Antibodies  >5 publications with SUMF1 and Neurobehavioral Manifestations
 Atrophy Antibodies  >4 publications with SUMF1 and Atrophy
 Abnormalities, Multiple Antibodies  >4 publications with SUMF1 and Abnormalities, Multiple
 Inflammation Antibodies  >2 publications with SUMF1 and Inflammation
Organs/Tissues associated with anti-SUMF1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with SUMF1 and Brain
 Blood Antibodies  >8 publications with SUMF1 and Blood
 Bone Antibodies  >8 publications with SUMF1 and Bone
 Liver Antibodies  >4 publications with SUMF1 and Liver
 Bone Marrow Antibodies  >4 publications with SUMF1 and Bone Marrow
 Spleen Antibodies  >2 publications with SUMF1 and Spleen
 Skin Antibodies  >2 publications with SUMF1 and Skin
 Heart Antibodies  >2 publications with SUMF1 and Heart
 Eye Antibodies  >1 publications with SUMF1 and Eye
 Intestine Antibodies  >1 publications with SUMF1 and Intestine
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