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anti-SUPT16H antibody :: Rabbit anti-Human, Mouse SUPT16H / FACTP140 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240995
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SUPT16H / FACTP140, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human SUPT16H / FACTP140

 Product Synonym Names    Anti-SUPT16H / FACTP140 Antibody (aa321-640) IHC-plus; SUPT16H; CDC68; FACT140; FACT; FACT complex subunit SPT16; FACT 140 kDa subunit; HSPT16; SPT16/CDC68; FACTP140; Human SUPT16H; FACTP140
 Product Gene Name   

anti-SUPT16H antibody

[Similar Products]
 Product Synonym Gene Name    FACTP140 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605012
 3D Structure    ModBase 3D Structure for Q9Y5B9
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recombinant protein comprised of GST and amino acids 321-640 of human SUPT16H
 Purity/Purification    Purified
 Form/Format    PBS, 0.08% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human SUPT16H.
 Immunogen Type    Recombinant protein
 Immunogen    SUPT16H / FACTP140 antibody was raised against recombinant human SUPT16H.
 Antigen Modification    aa321-640
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 Preparation and Storage    Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-SUPT16H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SUPT16H antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-SUPT16H antibody    IHC-P (20 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-SUPT16H antibody    Anti-SUPT16H antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-SUPT16H antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SUPT16H. It may not necessarily be applicable to this product.
 NCBI GI #    6005757
 NCBI GeneID    11198
 NCBI Accession #    NP_009123.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007192.3 [Other Products]
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 UniProt Primary Accession #    Q9Y5B9 [Other Products]
 UniProt Secondary Accession #    Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0 [Other Products]
 UniProt Related Accession #    Q9Y5B9 [Other Products]
 Molecular Weight    119,914 Da
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 NCBI Official Full Name    FACT complex subunit SPT16
 NCBI Official Synonym Full Names    suppressor of Ty 16 homolog (S. cerevisiae)
 NCBI Official Symbol    SUPT16H [Similar Products]
 NCBI Official Synonym Symbols   
CDC68; FACTP140; SPT16/CDC68
[Similar Products]
 NCBI Protein Information    FACT complex subunit SPT16; hSPT16; FACT 140 kDa subunit; facilitates chromatin remodeling 140 kDa subunit; facilitates chromatin transcription complex subunit SPT16; chromatin-specific transcription elongation factor 140 kDa subunit
 UniProt Protein Name    FACT complex subunit SPT16
 UniProt Synonym Protein Names   
Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16
 UniProt Gene Name    SUPT16H [Similar Products]
 UniProt Synonym Gene Names    FACT140; FACTP140; hSPT16 [Similar Products]
 UniProt Entry Name    SP16H_HUMAN
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 NCBI Summary for SUPT16H    Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
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 UniProt Comments for SUPT16H    SPT16: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the peptidase M24 family. SPT16 subfamily. Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with NEK9. Binds to histone H2A-H2B. Interacts with GTF2E2.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; chromosome; nucleus

Molecular Function: protein binding

Biological Process: transcription from RNA polymerase II promoter; nucleosome disassembly; viral reproduction; positive regulation of viral transcription; positive regulation of RNA elongation; RNA elongation from RNA polymerase II promoter; gene expression; DNA repair; DNA replication
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 Research Articles on SUPT16H    1. In the absence of FACT complex, SSRP1 and SPT16 mRNAs are unstable and inefficiently translated, making reactivation of FACT function unlikely in normal cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SUPT16H antibodyPathways associated with anti-SUPT16H antibody
 Reference Product  PubMed Publications
 SSRP1 antibody  >19 publications with SUPT16H and SSRP1
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway antibodies  Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 HIV Transcription Elongation Pathway antibodies  HIV Transcription Elongation Pathway Diagram
 HIV Elongation Arrest And Recovery Pathway antibodies  HIV Elongation Arrest And Recovery Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with anti-SUPT16H antibodyOrgans/Tissues associated with anti-SUPT16H antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >3 publications with SUPT16H and Chromosome Aberrations
 Sarcoma Antibodies  >1 publications with SUPT16H and Sarcoma
 Abnormalities, Multiple Antibodies  >1 publications with SUPT16H and Abnormalities, Multiple
 Heart Diseases Antibodies  >1 publications with SUPT16H and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with SUPT16H and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with SUPT16H and Muscle
 Heart Antibodies  >1 publications with SUPT16H and Heart
 Blood Antibodies  >1 publications with SUPT16H and Blood
 Lung Antibodies  >1 publications with SUPT16H and Lung
 Brain Antibodies  >1 publications with SUPT16H and Brain
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