NP_612634.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 44 kDa Predicted: 45 kDa
NCBI Official Full Name
synaptotagmin-8 isoform 2
NCBI Official Synonym Full Names
synaptotagmin 8
NCBI Protein Information
synaptotagmin-8
UniProt Protein Name
Synaptotagmin-8
UniProt Synonym Protein Names
Synaptotagmin VIII; SytVIII
UniProt Synonym Gene Names
NCBI Summary for SYT8
This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
UniProt Comments for SYT8
Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca2+-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca2+-regulation of exocytosis in insulin secreted cells ().
Research Articles on SYT8
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Products associated with anti-SYT8 antibody
Diseases associated with anti-SYT8 antibody
Organs/Tissues associated with anti-SYT8 antibody
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