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anti-SEMA3A antibody :: Rabbit Semaphorin-3A (N-terminal) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS472059
Testing Data
Unit / Price
0.1 mL  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Semaphorin-3A (N-terminal) (SEMA3A), Polyclonal Antibody

 Also Known As   

Semaphorin-3A (N-terminal)

 Product Synonym Names    Sema3A; Semaphorin III
 Product Gene Name   

anti-SEMA3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (83587659..83824217, complement). Location: 7p12.1
 OMIM    603961
 3D Structure    ModBase 3D Structure for Q14563
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    The antibody detects a 95kDa* protein corresponding to the apparent molecular mass of Sema3A on SDS-PAGE immunoblots of human recombinant Sema3A/Fc chimera. This antibody has not been shown to be reactive in neonatal rat brain, but has weak reactivity in adult mouse brain.
 Purity/Purification    Affinity Purified
 Form/Format    Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    Semaphorin 3A synthetic peptide (coupled to carrier protein) corresponding to amino acids in the N-terminal region of human Sema3A. The sequence used is identical to similar regions in rat and mouse Sema3A, and has low homology to other semaphorin family members.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-SEMA3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SEMA3A antibody

   One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI-anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co-receptors, Neuropilin-1 and Plexin-A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3Acontaining region. Thus, Sema3A and its co-receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.
 Applications Tested/Suitable for anti-SEMA3A antibody   

ELISA, Western Blot

 Application Notes for anti-SEMA3A antibody    ELISA: 1:2000
Western Blot: 1:1000
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 Testing Data of anti-SEMA3A antibody    anti-SEMA3A antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SEMA3A. It may not necessarily be applicable to this product.
 NCBI GI #    5174673
 NCBI GeneID    10371
 NCBI Accession #    NP_006071.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006080.2 [Other Products]
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 UniProt Primary Accession #    Q14563 [Other Products]
 UniProt Related Accession #    Q14563; Q75MQ2; Q86UJ2 [Other Products]
 Molecular Weight    86487 Da [Similar Products]
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 NCBI Official Full Name    semaphorin-3A
 NCBI Official Synonym Full Names    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 NCBI Official Symbol    SEMA3A [Similar Products]
 NCBI Official Synonym Symbols   
SemD; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; MGC133243
[Similar Products]
 NCBI Protein Information    semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III; OTTHUMP00000161379; OTTHUMP00000208884
 UniProt Protein Name    Semaphorin-3A
 UniProt Synonym Protein Names   
Semaphorin III
 Protein Family    Semaphorin
 UniProt Gene Name    SEMA3A [Similar Products]
 UniProt Synonym Gene Names    SEMAD [Similar Products]
 UniProt Entry Name    SEM3A_HUMAN
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 NCBI Summary for SEMA3A    This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq]
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 UniProt Comments for SEMA3A    Function: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1

Subcellular location: Secreted

Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similarities: Belongs to the semaphorin family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 PSI domain.Contains 1 Sema domain.
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Product References and Citations for anti-SEMA3A antibody

   • Kolodokin, A.L. et al. (1993) Cell 75:1389.
• Luo, Y. et al. (1993) Cell 75:217.
• Pasterkamp, R.J. & Verhaagen, J. (2001) Brain Res Rev 35:36.
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 Research Articles on SEMA3A    1. Both systemic and tumor-targeted delivery of SEMA3A inhibits tumor angiogenesis and tumor growth in multiple mouse models; moreover, SEMA3A inhibits the metastatic spreading from primary tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SEMA3A antibodyPathways associated with anti-SEMA3A antibody
 Reference Product  PubMed Publications
 NRP1 antibody  >38 publications with SEMA3A and NRP1
 SEMA3B antibody  >6 publications with SEMA3A and SEMA3B
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
Diseases associated with anti-SEMA3A antibodyOrgans/Tissues associated with anti-SEMA3A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with SEMA3A and Neoplasms
 Carcinoma Antibodies  >13 publications with SEMA3A and Carcinoma
 Lung Neoplasms Antibodies  >10 publications with SEMA3A and Lung Neoplasms
 Adenocarcinoma Antibodies  >9 publications with SEMA3A and Adenocarcinoma
 Inflammation Antibodies  >8 publications with SEMA3A and Inflammation
 Congenital Abnormalities Antibodies  >7 publications with SEMA3A and Congenital Abnormalities
 Breast Neoplasms Antibodies  >6 publications with SEMA3A and Breast Neoplasms
 Drug Toxicity Antibodies  >6 publications with SEMA3A and Drug Toxicity
 Glioma Antibodies  >5 publications with SEMA3A and Glioma
 Heart Defects, Congenital Antibodies  >4 publications with SEMA3A and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >228 publications with SEMA3A and Brain
 Embryonic Tissue Antibodies  >133 publications with SEMA3A and Embryonic Tissue
 Blood Antibodies  >72 publications with SEMA3A and Blood
 Eye Antibodies  >47 publications with SEMA3A and Eye
 Muscle Antibodies  >31 publications with SEMA3A and Muscle
 Kidney Antibodies  >26 publications with SEMA3A and Kidney
 Lung Antibodies  >23 publications with SEMA3A and Lung
 Heart Antibodies  >21 publications with SEMA3A and Heart
 Skin Antibodies  >15 publications with SEMA3A and Skin
 Connective Tissue Antibodies  >10 publications with SEMA3A and Connective Tissue
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